DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and grid2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	956	Identity:	239/956 - (25%)
Similarity:	424/956 - (44%)	Gaps:	161/956 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLCPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVN-NMKFSEL 64
            |::.|.|:  |:|....||....|   ..:.|.:||||.|:.|:.:..|..|..::| |.:..|.
Zfish     1 MKVFPAVL--FLITFWSLEWEPVL---PDSIIHIGAIFDESAKKDDEVFRMAVADLNLNNEILET 60

  Fly    65 RFVTIK-RYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEA 128
            ..:|:. .::..|:.|...|..|||::.|:.|:.......::..:..:|:|..|||: :..:..|
Zfish    61 EKITVSVEFVDGNNPFQAVQEACELMNRGILALVSSIGCMSAGSLQSLADAMHIPHL-FIQRAPA 124

  Fly   129 ----------TRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLM 183
                      ||.:..::  ::.|.|.: .|:...|::: ..|.|:.|.:.|:|...:..:::.:
Zfish   125 GTPRSSCPPTTRAQPDDY--TLFVRPPV-YLNDVIFQVV-MEYTWQKFIIFYDTDYDIRGIENFL 185

  Fly   184 ----------NIQALNSDY----------VKLRNLADYADDYRILWKETDETFHEQRIILDCEPK 228
                      ::|.:.|:.          :::..|..|.|..|             |.:|...|.
Zfish   186 DQTSQQGMDVSLQKVESNINMMITGMFRTMRVEELHRYRDTLR-------------RAVLFMSPA 237

  Fly   229 TLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKV-VDANPFERKKTR 292
            |.|..:...::..|......|.:.:.:..:..::::..:.. ..:|.||... :..|..:|....
Zfish   238 TAKAFITEVVETNLVAFDCQWIIINEEISDMDVQELVMKSI-GRLTLVRQTFPLPQNTSQRCVRN 301

  Fly   293 LTKVDQIL-----GNQTMLPI---LIYDAVVLFASSARNVIAAMQPFHPPNRHC--GSSSPWMLG 347
            ..:::..|     ....||.|   .|||.|:|.|::....:...:.....:..|  ..|.||..|
Zfish   302 NHRINTSLCDPKDPKAQMLEITNRYIYDTVLLLANTFHRKLEDRKWHSMASLSCIRKGSKPWQGG 366

  Fly   348 AFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEP-------MMVWTPDNGIK 405
            .   :.::|:.:..|..  .|..::.::.|...:.:.||......|.       :..|.|.:|:.
Zfish   367 K---SMLETVKKGGVSG--LTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLATWDPIHGLN 426

  Fly   406 KRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGR-EKYEGYAVDLISKLSEL 469
            ..|.:.:||:       :.:..|..|||..|||:.|:.   ||..|: :||:|:::|::..|:..
Zfish   427 GTLTDRKLEN-------NMRGVVLRVVTVLEEPFVMVS---ENVLGKPKKYQGFSIDVLDALANY 481

  Fly   470 MEFDYEFMIVNGNGKYNPETKQ--WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGI 532
            :.|.||..:...: ||..:...  |:|:|.:|:...|.:|:..||||..|.||||||..:|...:
Zfish   482 LGFKYEIYVAPDH-KYGSQQADGTWNGLIGELVFKRADVGLSALTITPERESVVDFTTRYMDYSV 545

  Fly   533 SILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIM-TLAFVFIARLSYREWLPPNPAIQDPDEL 596
            .:|..|: ....:.||.|.||.:.:|..:....|:: ||.::.       .||.| |.:  |...
Zfish   546 GVLLRKA-ERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLL-------NWLNP-PRL--PMGS 599

  Fly   597 ENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSS 661
            .:...:.||.|.:.||.:|||.::.......|::.|:||.|||:::|:||||||||||.::.::|
Zfish   600 VSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENS 664

  Fly   662 IKSLQDLIEQDKVHFGS---------MRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTN-- 715
            |:|||||.:|..:.:|:         :|....:.|   ..|..|.:.|..:   |.:.....|
Zfish   665 IQSLQDLAKQTDLPYGTVLDSAVYDQVRSKGMNPF---ERDPMYSQMWRMI---NRTGGAENNVE 723

  Fly   716 --KEGVARVRKEKGGYAFLMETTSLTYNI--ERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSV 776
              |||:.:|:  .|.:||:.:...|.|..  :.:|.|..:...:.::.||:|:..||.||...|.
Zfish   724 ESKEGIRKVK--YGRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQ 786

  Fly   777 SILQLSERGELQKMKNKWWKNHNVTCDSYHEV----DGDELSIIELGGVFLVLAGGVLIGVILGI 837
            .||:|.:.|::..:|.|||...: .||.|..|    .|..|.|....|||.|||.||::..::..
Zfish   787 RILELQQNGDMDILKLKWWPRDS-PCDLYSPVGTRKSGSALDIHSFAGVFFVLAAGVVLSCLIAT 850

  Fly   838 FEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSD 883
            .|               .|             |.|:|..|:.|..|
Zfish   851 VE---------------TW-------------WTRRKGSRVPSKED 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	79/420 (19%)
		ANF_receptor	46..386	CDD:279440	68/382 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	123/388 (32%)
		Lig_chan	556..828	CDD:278489	91/291 (31%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	80/422 (19%)
		ANF_receptor	42..404	CDD:279440	70/385 (18%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/388 (32%)
		Lig_chan	568..841	CDD:278489	91/291 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740