DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GluRIB

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster

Alignment Length:	967	Identity:	256/967 - (26%)
Similarity:	423/967 - (43%)	Gaps:	186/967 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP---TNDSFLLQQITCELISNG 92
            :|.:||||.:...|::.:|..|... :|:..|..|| .::.|:.   |.|:|.|.::.|...|.|
  Fly    41 KIPLGAIFEQGTDEVQSAFKYAMLN-HNLNVSSRRF-ELQAYVDVINTADAFKLSRLICNQFSRG 103

  Fly    93 VAAIFGPSSKAASDIVAQIANATGIPHIE--YDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFE 155
            |.::.|..|..:.|.:...:|...:|.:.  :..|:.......|:..:|:......:::....|
  Fly   104 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQF- 167

  Fly   156 IIKSNYEWRTFTLIYETPEGLARLQDL-MNIQALNSDY-----VKLRNLADYADDYRILWKETDE 214
                 |.||....:|::.:||.|||.: ..::..|..:     .::.|::...:....|  |...
  Fly   168 -----YGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL--EQIG 225

  Fly   215 TFHEQRIILDCEPKTLKELLKVSI-DFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKA-NITSVR 277
            .|..:.|:|||..:..|::|...: |.:|.....::.|:.|...:....:|.  :|.| |||..|
  Fly   226 RFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEII--EFGAINITGFR 288

  Fly   278 LKVVDANPFERKKTR-----LTKVDQIL----GNQTM--LPILIYDAVVLFASSARNVIAAMQPF 331
              :||.|   |:..|     ..::|..:    |.:::  ...|:||||.:.. .|.|.|...:|.
  Fly   289 --IVDTN---RRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLV-EAFNKILRKKPD 347

  Fly   332 HPPNR---------------------------------------HCGSSS--------------- 342
            ...|.                                       ..||.|
  Fly   348 QFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNT 412

  Fly   343 ------PWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMM---VW 398
                  .|..|..|...::.:..:.:     |.::|.::.|:|:::.|.:.:.|||..|:   .|
  Fly   413 AKGWVNAWEHGDKISRYLRKVEIEGL-----TGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEW 472

  Fly   399 TPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKE--DHENFRGREKYEGYAVD 461
            ..|.|::.  ||.:........:| |:.:.|.|.|..||||.|:|:  ..|...|..::|||..|
  Fly   473 NDDAGLQP--LNAKYVRLRPHVEF-EKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKD 534

  Fly   462 LISKLSELMEFDYEFMIVNGNGKYNPETKQ----WDGIIRKLIDHHAQIGVCDLTITQMRRSVVD 522
            |...|::.:..:||..:|. :|.|..|...    |||::.:|:...|.|.:..:|||..|..|:|
  Fly   535 LADLLAKELGINYELRLVK-DGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVID 598

  Fly   523 FTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWL--- 584
            |:.|||.|||||:..|...:....|:|:.|.:.|:|:.:||:.:.:::...|::|.|..||.
  Fly   599 FSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQ 663

  Fly   585 -------------------------------------PPNPAIQ--------------------- 591
                                                 ||.|..|
  Fly   664 QQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGG 728

  Fly   592 DPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSN 656
            ....:.|.::|.||.|..:.:.||||||:.||....||....|:||.|:::|:||||||||||..
  Fly   729 SSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVE 793

  Fly   657 KWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVAR 721
            :..:.|.|.:||..|.:|.:|::..|||..||..|....:.:.|..|.. ....|..|..||:.|
  Fly   794 RMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNS-RKHVFVPTYDEGIKR 857

  Fly   722 VRKEKGGYAFLMETTSLTY-NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERG 785
            ||..||.||.|:|:....| |....||..::|..:..|.:|:|.||||..:..:::::|.|.|.|
  Fly   858 VRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENG 922

  Fly   786 ELQKMKNKWWKNHNVTCDSYH--EVDGDELSIIELGGVFLVLAGGVLIGVILGIFEF 840
            ||.|::|||| .....|.::.  |....|||:..:.|:|.:|.||:|:.|.:.|.|:
  Fly   923 ELIKLRNKWW-YEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEY 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	94/457 (21%)
		ANF_receptor	46..386	CDD:279440	83/423 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	141/437 (32%)
		Lig_chan	556..828	CDD:278489	102/335 (30%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	94/457 (21%)
		ANF_receptor	55..461	CDD:279440	83/428 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	142/443 (32%)
		Lig_chan	632..967	CDD:278489	103/336 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462509
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.740