DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GluRIID

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	278/924 - (30%)
Similarity:	453/924 - (49%)	Gaps:	117/924 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTI---KRYMPTNDSFLLQQITCELISNGV 93
            |.:|.|..:....|..:|:.|...|||    ||....:   ::....|......|: |.|:.:||
  Fly    34 IRLGLITDDATDRIRQTFEHAISVVNN----ELGVPLVGETEQVAYGNSVQAFAQL-CRLMQSGV 93

  Fly    94 AAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIK 158
            .|:|||:::..:..:....::..||.|...|...:...       ..|:.||...::.|.::|:
  Fly    94 GAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPD-------GFNLHPSPEDIANALYDIV- 150

  Fly   159 SNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLR----NL-ADYADDYRILWKETDETFHE 218
            :.:||..|...||:.|.|..|..||....:....:|:.    || .:|....|.:.|..|
  Fly   151 NQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSED----- 210

  Fly   219 QRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDI-YNEDFKANITSVRLKVVD 282
            .||::......:.|||:.:....:......:.:.:|:.|...|.:. |:|   ||||.:|:...|
  Fly   211 SRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSE---ANITGIRMFSPD 272

  Fly   283 ANPFERKKTRLTKVDQILGNQ----------TMLPILIYDAVVLFASSARNVIAAMQPFHPPNRH 337
            .   |..:..:.|:.|.||..          ||...|.||||.:.|.:.:::     |:.|...:
  Fly   273 Q---EEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHL-----PYQPQMLN 329

  Fly   338 CGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDN 402
            |..                 ..|:|:|...|    ...|.:    :|||.:.|:...:..   :.
  Fly   330 CSE-----------------RHDNVQPDGST----FRNYMR----SLEIKEKTITGRIYF---EG 366

  Fly   403 GIKKRLL--NLELESAGTT--------QDFSEQR-----------------KVYTV-VTHYEEPY 439
            .::|...  .:||:::|..        :||..||                 |.:.| ::...:||
  Fly   367 NVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPY 431

  Fly   440 FMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQWDGIIRKLIDH 502
            ..:.|..:...|..:::||.||||.:|::.:.|::.|. ..||  |.:|..|....|:::::::.
  Fly   432 ASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR-DGGNDYGSFNKTTNSTSGMLKEIVEG 495

  Fly   503 HAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLI 567
            .|.:.:.|||||..|..|:||::|||.|||:||:.|....|...|:|::||:.|||:|:..|.|.
  Fly   496 RADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLG 560

  Fly   568 MTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTG 632
            ::|.|..|.|||..||..|.|.|::|:||||.:.:|||.|...|:::|||.:|.|:....|.::.
  Fly   561 VSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISA 625

  Fly   633 MWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIE-QDKVHFGSMRGGSTSLFFSESNDTDY 696
            :||||.|:|:|:||||||||||.....|.|.|::||.: :|.|.:|:.|.|||..|||.|.:..|
  Fly   626 IWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIY 690

  Fly   697 QRAWNQMKDFNPSAFTSTNKEGVARVRKEKGG--YAFLMETTSLTYNIERNCDLTQIGEQIGEKH 759
            .: .|:..:.:|......|::||.:|   |.|  ||||||:||:.:|..|.|:||::|:.:.||.
  Fly   691 IK-MNEYLNAHPEMLMENNQQGVDKV---KSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKG 751

  Fly   760 YGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNV-TCDSYHEVDG-DELSIIELGGVF 822
            ||:|:.....||...:.::|:|.|:|.|.::|||||..... .|.:..:.|| .||.:..|.|::
  Fly   752 YGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIY 816

  Fly   823 LVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSDKSSS 887
            :||..|.:|.:|:.|..:.:.|...|....|....|...|....::|...::|:: |:.|..|.|
  Fly   817 VVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLK-SAQSIYSRS 880

  Fly   888 RRSSGSRRSSKEKS 901
            |.||.|..|.|..|
  Fly   881 RNSSQSIESLKTDS 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	87/389 (22%)
		ANF_receptor	46..386	CDD:279440	81/358 (23%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	151/392 (39%)
		Lig_chan	556..828	CDD:278489	115/276 (42%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	92/418 (22%)
		ANF_receptor	46..380	CDD:279440	87/390 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	150/375 (40%)
		Lig_chan	549..819	CDD:278489	113/273 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462598
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.800