DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and CG11155

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	301/924 - (32%)
Similarity:	471/924 - (50%)	Gaps:	102/924 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKE--IELSFDQAFREVNNMK--FSEL 64
            |..:|.:.::|...|..:          |.|||||.|:|:|  ||.:|..|...:|..|  ....
  Fly    25 CSYIILSILVISNALPPV----------IRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNT 79

  Fly    65 RFVTIKRYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEAT 129
            :.|....|:|.:|||...:..|..:..||.|||||:....:..|..|..|..|||||..:.||..
  Fly    80 QLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYN 144

  Fly   130 RQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVK 194
            .:|     .|||:.||.::|:.||.:|: ....|....:|||...||.   :||:........:.
  Fly   145 SKE-----FSINLYPSHTLLTLAYRDIM-VYLNWTKVAIIYEEDYGLF---NLMHSSTETKAEMY 200

  Fly   195 LRNLADYADDYR-----ILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHL 254
            :|..:  .|.||     |..||.      .:||:|..|..:|...:..:..::.....::..|..
  Fly   201 IRQAS--PDSYRQVLRAIRQKEI------YKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTF 257

  Fly   255 DTHNSGLRDI-YNEDFKANITSVRLKVVDANPF-----ERKKTRLTKVDQILGN---QTMLPILI 310
            |.....|.|. ||   ..|||:.||..||:..:     :.:|.:...:|.|.|:   ||. ..|:
  Fly   258 DLETYDLEDFRYN---SVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTE-SALM 318

  Fly   311 YDAVVLFASSARNV-IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLD 374
            :|:|..||:....: :...|.|:..|..|.|...|..|..:.|::.....|.:     |..::..
  Fly   319 FDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGL-----TGTVQFV 378

  Fly   375 EYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIK---------KRLLNLELESAGTTQDFSEQRKV 428
            | |:|..|.|:|.|....:...|  |.||:|:.         ..:.|:.|
  Fly   379 E-GRRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNIANITL--------------- 427

  Fly   429 YTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQ 491
             .|:|..|.||.|:||| :|..|..::||:.:||:..::..:.|.|:..:|..|  |.|.|||..
  Fly   428 -VVMTREERPYVMVKED-KNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNS 490

  Fly   492 WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVE 556
            |:||:::|::..|.:.|..:||...|.||:|||.|||.|||.||......:|...|:|:.|.|:|
  Fly   491 WNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIE 555

  Fly   557 VWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL 621
            :|:|::.|.::::.|...:||.|..||..|:|..::.|.:||.::::||.|.:.|:.::||..:.
  Fly   556 IWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLN 620

  Fly   622 PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSL 686
            |:....||:.|.|:||.|:::|:||||||||||..:..|.|:|..||.||.::.:|::.||||..
  Fly   621 PKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMT 685

  Fly   687 FFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQI 751
            ||.:|....||:.|..|::...:.|..|.::|:.||.  :|.||||||:|.|.|.::|:|:||||
  Fly   686 FFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVM--EGSYAFLMESTMLDYAVQRDCNLTQI 748

  Fly   752 GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTC---DSYHEVDGDEL 813
            |..:..|.||:|.|.||.:|..:|::||:|.|:|.:|.:.:|||||....|   |...|...:.|
  Fly   749 GGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANAL 813

  Fly   814 SIIELGGVFLVLAGGVLIGVILGIFEFLWNV-QNVAVEERVTPWQAFKAELIFALKFWVRKKPMR 877
            .:..:||||:||..|:.:.|::.||||.||. :|:..|.     |:..:|:...|:|     .|.
  Fly   814 GVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTEN-----QSLCSEMAEELRF-----AMH 868

  Fly   878 ISSSSDKSSSRRSS 891
            ...|..:...|:.|
  Fly   869 CHGSKSRHRPRKRS 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	113/391 (29%)
		ANF_receptor	46..386	CDD:279440	98/356 (28%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	149/371 (40%)
		Lig_chan	556..828	CDD:278489	111/274 (41%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	114/392 (29%)
		ANF_receptor	61..393	CDD:279440	99/358 (28%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	151/387 (39%)
		Lig_chan	555..829	CDD:278489	111/275 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462688
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.750