DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and KaiR1D

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	317/866 - (36%)
Similarity:	482/866 - (55%)	Gaps:	90/866 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREVNN----MKFSELRFVTIKRYMPTNDSFLLQQITCELISNG 92
            |.:|.:|:..:...||:|.||...:|.    :..|:| ...|:|..|. |||...:..|.|::.|
  Fly    30 IKIGGLFHPADDHQELAFRQAVDRINADRSILPRSKL-VAQIERISPF-DSFHAGKRVCGLLNIG 92

  Fly    93 VAAIFGPSSKAASDIVAQIANATGIPHIE--YDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFE 155
            |||||||.|...:..|..|.:...|||:|  :|.:|   |:|    ...:|:.|..:.||:||.:
  Fly    93 VAAIFGPQSSHTASHVQSICDNMEIPHLENRWDYRL---RRE----SCLVNLYPHPNTLSKAYVD 150

  Fly   156 IIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQR 220
            |:: ::.|:|||:|||..:|:.|||:|:....:....:.:|.|:| :.|||.|.|:...: .|..
  Fly   151 IVR-HWGWKTFTIIYENNDGIVRLQELLKAHGMTPFPITVRQLSD-SGDYRPLLKQIKNS-AEAH 212

  Fly   221 IILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK---ANITSVRL---K 279
            |:|||..:.:.|:||.:....:...:.::.:|.||.|...|     ::|:   .|||..||   |
  Fly   213 IVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNL-----DEFRYGGTNITGFRLINEK 272

  Fly   280 VVDANPFERKKTRLTKVDQ--ILGNQTMLPI-----LIYDAVVLFASSARNVIAAMQ-PFHPPNR 336
            :|.      ...|...:|:  :|.:..:..:     |:||||.|||.:..::..:.| ..||.:
  Fly   273 IVS------DVVRQWSIDEKGLLRSANLTTVRSETALMYDAVHLFAKALHDLDTSQQIDIHPIS- 330

  Fly   337 HCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYK--PTVNEPMMVWT 399
             |...|.|..|..::|.||.     ||....|..:|.|..|.|..|.|:|.:  |.....:..|.
  Fly   331 -CDGQSTWQHGFSLINYMKI-----VEMKGLTNVIKFDHQGFRTDFMLDIVELTPAGIRKIGTWN 389

  Fly   400 ---PDNGIKKRLLNLELESAGTTQDFSEQR---------KVYTVVTHYEEPYFMMKEDHENFRGR 452
               || ||            ..|:.||:::         |...|.|....||.|.||......|.
  Fly   390 STLPD-GI------------NFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLSGN 441

  Fly   453 EKYEGYAVDLISKLSELMEFDYEFMIV-NGN-GKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQ 515
            :::||||||||.::|:.:.|:|:..:| :|: |..|..|.:|:|:||:|::..|.:.:.|||||.
  Fly   442 DQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITF 506

  Fly   516 MRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSY 580
            .|...||||.|||.||:|||:.|...:|.|.|:||.|.:::|||||..|.|.:::....:|:.:.
  Fly   507 EREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTP 571

  Fly   581 REWLPPNPAIQDP--DELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643
            .||    ||..|.  :::|:.:.:.|..|..:||:||||||.||:....|::.|:||||.|:|:|
  Fly   572 YEW----PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMIS 632

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNP 708
            :||||||||||..:..|.|:|.:||.:|.::.:|:::||||:.||.:|..:.|||.|:.|:...|
  Fly   633 SYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARP 697

  Fly   709 SAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTN 773
            |.||::|.|||.||.|.||.||||||:||:.|..||||:|||:|..:..|.||:|.|..|.|||.
  Fly   698 SVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTA 762

  Fly   774 LSVSILQLSERGELQKMKNKWWKNH--NVTC---DSYHEVDGDELSIIELGGVFLVLAGGVLIGV 833
            ::..||:|.|.|:|..:|.||||..  ...|   .|......:||.:..:||||:||.||:.:..
  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827

  Fly   834 ILGIFEFLWNVQNVAVEERVT 854
            ::.:.||:|..:.||||||::
  Fly   828 VIAVCEFVWKSRKVAVEERLS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	120/395 (30%)
		ANF_receptor	46..386	CDD:279440	113/359 (31%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	168/382 (44%)
		Lig_chan	556..828	CDD:278489	124/278 (45%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	122/408 (30%)
		ANF_receptor	42..378	CDD:279440	114/365 (31%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	168/373 (45%)
		Lig_chan	547..823	CDD:278489	125/279 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.820