Protein Alignment GluRIIA and Ir93a

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Alignment Length: 897
• Identity: 161/897 - (17%)
• Similarity: 305/897 - (34%)
• Gaps: 256/897 - (28%)

  Fly   124 LKLEATRQEQLNHQ-MSINVAPSLSVLSRAYFEIIKSN----------YEWRTFTLIYETPEGLA 177
            |...|:....::|: |:::....|:...:...::|:.|          :.|
  Fly    35 LSANASLAVVVDHEYMTVHGENILAHFEKILSDVIRENLRNGGINVKYFSW-------------- 85

  Fly   178 RLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIIL------DCEPKTLKELLKV 236
                  |...|..|::....:.|..:.:. .:|.|.||    .|:|      ||....|...|.|
  Fly    86 ------NAVRLKKDFLAAITVTDCENTWN-FYKNTQET----SILLIAITDSDCPRLPLNRALMV 139

  Fly   237 SI------------DFKLQGPFRNW-----FL--THLDTHNSGLRDIYNEDFKANITSVRLKVVD 282
            .|            |.|:| ...||     |:  |.|:.:...::.|.:|....:||.:.|.:.:
  Fly   140 PIVENGDEFPQLILDAKVQ-QILNWKTAVVFVDQTILEENALLVKSIVHESITNHITPISLILYE 203

  Fly   283 ANPFERKKTRLTKVDQIL-------------------------------------GNQTMLPIL- 309
            .|...|.:.:...:.|.|                                     |||.|:.:|
  Fly   204 INDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLD 268

  Fly   310 ----IYDA--VVLFASSARNVIAAMQPFHP---PNRHCGSSSPWMLGAFIVNEMK--TISEDDVE 363
                .:||  |.:......|:..|:....|   .:.:|..|.   :...:||.:.  |:.|:.:.
  Fly   269 MVARDFDAGTVTINLDEGANIAFALNETDPNCQDSLNCTISE---ISLALVNAISKITVEEESIY 330

  Fly   364 PHFKTEN------MKLDEYGQRIHFNLEIYKPTVN---------EPMMVW-----------TPDN 402
            .....|.      .|.::..:.:.:..|..|....         |..:.|           ||..
  Fly   331 GEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKFRSTPQR 395

  Fly   403 GIKKRLLNLELESAG---TTQDFSEQRKVYTVVTH------------YEEPYFMMKEDHENFRG- 451
            ..|.|  |.|..:.|   ....|..|...:..:.|            :..|:.::.   :|..|
  Fly   396 DAKNR--NFEFINIGYWTPVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQILT---KNSNGV 455

  Fly   452 REKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQWD----------------------- 493
            ..:::|..::::.:||..:.|.|          |..|...|.
  Fly   456 IVEHKGIVMEIVKELSRALNFSY----------YLHEASAWKEEDSLSTSAGGNESDELVGSMTF 510

  Fly   494 ----GIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHY----KSPPEPKNQFAFL 550
                .::..:..:...|.....|:....:...::|.|     ||:..|    :.|.|....:.|.
  Fly   511 RIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQP-----ISVQKYSFITRKPDEVSRIYLFT 570

  Fly   551 EPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQ 615
            .||.||.|..::...|:.......|.||:..:.:          .:..:..|.:..|.:.|:::|
  Fly   571 APFTVETWFCLMGIILLTAPTLYAINRLAPLKEM----------RIVGLSTVKSCFWYIFGALLQ 625

  Fly   616 QGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIE-QDKVHFGSM 679
            ||...||.....|::.|.||...:::::||..||.||||..|:|..:..|..|.: :|.|.:|..
  Fly   626 QGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLR 690

  Fly   680 RGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNI-- 742
            .|.....:...:...|::....:.|     .:.|..:|.:..|::.        |..::.:.|
  Fly   691 NGTFFERYVQSTTREDFKHYLERAK-----IYGSAQEEDIEAVKRG--------ERINIDWRINL 742

  Fly   743 ----------ERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN 797
                      |:.|......|...::...:.||..|.|...::..|..:...|.:::     |..
  Fly   743 QLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQ 802

  Fly   798 HNV----TCD---SYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLW 842
            .|:    .|:   :..:|...::::.::.|.||||..|..:.:::...|| |
  Fly   803 MNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEF-W 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	66/391 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	75/426 (18%)
		Lig_chan	555..828	CDD:459656	60/292 (21%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:473866	58/295 (20%)
		Lig_chan	574..836	CDD:459656	57/289 (20%)