DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and gria4a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	895	Identity:	286/895 - (31%)
Similarity:	458/895 - (51%)	Gaps:	84/895 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IIIIGFLEGIIALG-GDDRNEITVGAIFYENEKEIELSFDQA-FREVNNMKFSELRFVTIKRY-- 72
            :::|..|.|   || |...:.:.:|.:|..|..:...:|..| |....:...:|..|..:...
Zfish     4 LVLIPLLWG---LGEGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDN 65

  Fly    73 MPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQ 137
            :.|.:||.:....|...|.||.||||...|.:...:....:|..|..:......|...|..|..:
Zfish    66 IETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLR 130

  Fly   138 MSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYA 202
            .||..| .||:|         .:|:|..|..:|:|..|.|.||.:|.....|...|....:.::.
Zfish   131 PSIRGA-LLSLL---------DHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFN 185

  Fly   203 D-DYRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTHLDTHNSGLRDI 264
            | .||.|.::.|.. .|::.::|.|.:.|:.:|:  ||:...::|       .|....|.|.:||
Zfish   186 DASYRRLLEDLDRR-QEKKFVIDLEAERLQNILEQIVSVGKHVKG-------YHYIVANLGFKDI 242

  Fly   265 YNEDFK---ANITSVRLKVVD-ANPFERK-KTRLTKVDQ--ILGNQT---MLPILIYDAVVLFAS 319
            ..|.|.   ||:|..:|  || :.|...| ..|..|:||  ..|:::   ....|.||.|::.|.
Zfish   243 SLERFMHGGANVTGFQL--VDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAE 305

  Fly   320 SARNV----IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRI 380
            :.||:    |...:..:..:.....::||..|..:...:|.:....:     |.|::.|.||:|:
Zfish   306 AFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGL-----TGNIQFDHYGRRV 365

  Fly   381 HFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMK 443
            ::.:::::...|.|..:  |   |.:.|.:|.....|.|  .|.:.:.:...|.|..|.||.|:|
Zfish   366 NYTMDVFELKSNGPRKIGYW---NDLDKLVLVQNELSMG--NDSAMENRTVIVTTIMEGPYVMLK 425

  Fly   444 EDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGIIRKLIDHHAQ 505
            ::.|.:.|.|::|||.|||.|::::.:...|:..||. :|||   :||||.|:|::.:|:...|:
Zfish   426 KNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVL-DGKYGARDPETKIWNGMVGELVYGKAE 489

  Fly   506 IGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTL 570
            |.|..|.||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:|:.::||.:.:::
Zfish   490 IAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 554

  Fly   571 AFVFIARLSYREWL----------PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGP 625
            ....::|.|..||.          ||:      |:..|.:.:.||.|..:|:.||||||..||..
Zfish   555 VLFLVSRFSPYEWHTEEPEEGSDGPPS------DQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSL 613

  Fly   626 HMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSE 690
            ..||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|||..||..
Zfish   614 SGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRR 678

  Fly   691 SNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-CDLTQIGEQ 754
            |....|::.|:.||...|:.||.|..||||||||.||.||||:|:|...|..:|. ||..::|..
Zfish   679 SKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGN 743

  Fly   755 IGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDE----LSI 815
            :..|.||:|.|.||...|.:::::|:|||.|.|.|:|||||.:.. .|........|:    ||:
Zfish   744 LDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYDKG-ECGPKDSGSKDKSSQALSL 807

  Fly   816 IELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAF--KAEL 863
            ..:.|||.:|.||:.:.:::.:.||.:..:..|.:.::|..:|.  ||.|
Zfish   808 SNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKLTFSEAMRNKARL 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	98/392 (25%)
		ANF_receptor	46..386	CDD:279440	91/359 (25%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	158/383 (41%)
		Lig_chan	556..828	CDD:278489	113/286 (40%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	99/397 (25%)
		ANF_receptor	34..375	CDD:279440	91/365 (25%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	159/389 (41%)
		Lig_chan	540..821	CDD:278489	114/287 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840