DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and gria1b

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	931	Identity:	263/931 - (28%)
Similarity:	444/931 - (47%)	Gaps:	160/931 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP 74
            :|::::..|.|:.:......| |.:|.:|..:..|.:: |..|..:.|::.    :.|.....:.
Zfish     4 SFVLLLTGLLGLCSCSSFPSN-INIGGLFPTDSHEYDV-FRFALSQHNDVP----KLVPQVDMVD 62

  Fly    75 TNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS 139
            |..||.:....|...|.||.||.|...:...:::.....|..:..:.....::.      |:|..
Zfish    63 TGSSFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFCGALHVCFVTPSFPIDT------NNQFV 121

  Fly   140 INVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMN--------IQALNSDYVK-- 194
            |.:.|.|.....|..|    :|:|..|..:|.:..||..||.:::        :.::|.|.:.
Zfish   122 IQLRPELQDALIALVE----HYKWNKFVYMYSSDSGLTVLQKILDTAAEKTWQVTSINFDTLTEA 182

  Fly   195 --LRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTH 257
              |:.:.|.            :...|.:||||||.:.|..:|.:....|..  .:|:   |....
Zfish   183 AFLKAIQDL------------DNKKEFKIILDCELERLNSILNLIAAQKKN--LKNY---HYILA 230

  Fly   258 NSGLRDIYNEDFK---ANITSVRL----------KVVDANPFERK-----KTRLTKVDQILGNQT 304
            |.|..|:...:|:   ||:|..:|          .:.|...|:.|     |.||....
Zfish   231 NLGFLDLNLTEFRKGGANVTGFQLMNYTNPTVSRTIQDWLEFDSKDLKSPKRRLKYTG------- 288

  Fly   305 MLPILIYDAVVLFASSARNV----------------IAAMQPFHPPNRHCGSSSPWMLGAFIVNE 353
               .|.||.|.:.|::.:|:                :|     :||       :||..|..|...
Zfish   289 ---ALTYDGVTVMATAFQNLRKQRIDISRRGNAGECLA-----NPP-------APWGQGIDIQRA 338

  Fly   354 MKTISEDDVEPHFKTENMKLDEYGQRIHFNLEI--YKPTVNEPMMVWTPDNGIKKRLLNLELESA 416
            ::.:..:.:..|     ::.::.|.|.:|.:.:  :.|:..:.:..|..    :::.::....|.
Zfish   339 LQQVQFEGLTGH-----VQFNDKGHRTNFTVSVMEFGPSGPKKVGYWNQ----REKYVSTATYSN 394

  Fly   417 GTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNG 481
            ...:.|..|.:.|.|.|..|.||.|:|::||...|.:|||||.|:|.:::::.:.:.|...:| |
Zfish   395 MLNETFGLQNRTYVVTTILEAPYVMLKKNHEQLVGNDKYEGYCVELAAEIAKHVGYSYRLELV-G 458

  Fly   482 NGKY---NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEP 543
            :|||   :.||..|:|::.:|:...|.:.|..||||.:|..|:||:.|||.|||||:..|.....
Zfish   459 DGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSK 523

  Fly   544 KNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREW---------------LPPNP-AIQD 592
            ...|:||:|.|.|:|:.::||.:.:::....::|.|..||               .||:| ..|.
Zfish   524 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQS 588

  Fly   593 PDELE--------------NIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643
            |::.:              |.:.:.||.|..:|:.|||||||.||....||:.|:||||.|:::|
Zfish   589 PNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIIS 653

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNP 708
            :||||||||||..:..|.|:|.:||.:|.::.:|::.||||..||..|....:::.|:.||...|
Zfish   654 SYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEP 718

  Fly   709 SAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-CDLTQIGEQIGEKHYGLAVPLGSDYRT 772
            :.|..|..|||.||||.||.||:|:|:|...|..:|. ||..::|..:..|.||:|.|.||..|.
Zfish   719 TVFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRN 783

  Fly   773 NLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDE------LSIIELGGVFLVLAGGVLI 831
            .:::::|:|:|:|.|.|:|||||.:.. .|.|   ..||.      ||:..:.|||.:|.||:.:
Zfish   784 PVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS---GGGDSKDKTSALSLSNVAGVFYILIGGLGL 844

  Fly   832 GVILGIFEFLWNVQNVAVEER 852
            .:::.:.||.:..:   :|.|
Zfish   845 AMLVALVEFCYKSR---IESR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	82/418 (20%)
		ANF_receptor	46..386	CDD:279440	77/385 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	156/403 (39%)
		Lig_chan	556..828	CDD:278489	114/308 (37%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	82/423 (19%)
		ANF_receptor	41..368	CDD:279440	77/384 (20%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	157/409 (38%)
		Lig_chan	536..842	CDD:278489	115/309 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740