DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and Ir76b

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_649176.1	Gene:	Ir76b / 40198	FlyBaseID:	FBgn0036937	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	126/539 - (23%)
Similarity:	208/539 - (38%)	Gaps:	105/539 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 KPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGR 452
            ||.:.| |:.|.  .|...|:..||        ||...   ||.|.             ||  |.
  Fly    70 KPKLRE-MLDWI--GGKHLRIATLE--------DFPLS---YTEVL-------------EN--GT 105

  Fly   453 EKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQWDGIIRKLID--HHAQIGVCDLTITQ 515
            ....|.:..:|..|.:...|.||.::...|...:|  ..:|   |.||:  :.:.:.:....|..
  Fly   106 RVGHGVSFQIIDFLKKKFNFTYEVVVPQDNIIGSP--SDFD---RSLIEMVNSSTVDLAAAFIPS 165

  Fly   516 M--RRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARL 578
            :  :||.|.::...:..|..|:..:.|.|..:....|.||  |.|::::....::.:..:..|.:
  Fly   166 LSDQRSFVYYSTTTLDEGEWIMVMQRPRESASGSGLLAPF--EFWVWILILVSLLAVGPIIYALI 228

  Fly   579 SYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643
            ..|..|       ..|..:..:::.:..|.:.|::|:||..:.|.....|:|...||.|..::.|
  Fly   229 ILRNRL-------TGDGQQTPYSLGHCAWFVYGALMKQGSTLSPIADSTRLLFATWWIFITILTS 286

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNP 708
            .|||||.||||.:|:.....::.|::.::| ||.|||||........:|::  ....|:|...|.
  Fly   287 FYTANLTAFLTLSKFTLPYNTVNDILTKNK-HFVSMRGGGVEYAIRTTNES--LSMLNRMIQNNY 348

  Fly   709 SAFT-STNKEGVARVRKEKGGYAFLMETTSLTYNIER---------------NCDLTQIGEQIGE 757
            :.|: .||.....:...||.||.|:.:..::...:.|               :|......|...:
  Fly   349 AVFSDETNDTYNLQNYVEKNGYVFVRDRPAINIMLYRDYLYRKTVSFSDEKVHCPFAMAKEPFLK 413

  Fly   758 KHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVF 822
            |....|.|:||:........:|.|.|.|.::.:             |...:...|:...:|||..
  Fly   414 KKRTFAYPIGSNLSQLFDPELLHLVESGIVKHL-------------SKRNLPSAEICPQDLGGTE 465

  Fly   823 LVLAGGVLI---GVILGIFEFLWNVQNVAVEERVTPWQAFKAELIF--------ALKFWVRKKPM 876
            ..|..|.|:   .::|..|              .|....|..||:|        |.| |.|....
  Fly   466 RQLRNGDLMMTYYIMLAGF--------------ATALAVFSTELMFRYVNSRQEANK-WARHGIG 515

  Fly   877 RISSSSDKSSSRRSSGSRR 895
            |..:....:.||...|.||
  Fly   516 RTPNGQSVAPSRWLRGWRR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	5/15 (33%)
		ANF_receptor	46..386	CDD:279440
		PBP2_iGluR_Kainate	426..796	CDD:270432	90/389 (23%)
		Lig_chan	556..828	CDD:278489	67/287 (23%)
Ir76b	NP_649176.1	Periplasmic_Binding_Protein_Type_2	83..437	CDD:304360	92/396 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840