DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GluRIA

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	268/908 - (29%)
Similarity:	429/908 - (47%)	Gaps:	126/908 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP---TNDSFLLQQITCELISNG 92
            :|.:||||.:...:::.:|..|... :|:..|..|| .::.|:.   |.|:|.|.::.|...|.|
  Fly    39 KIPLGAIFEQGTDDVQSAFKYAMLN-HNLNVSSRRF-ELQAYVDVINTADAFKLSRLICNQFSRG 101

  Fly    93 VAAIFGPSSKAASDIVAQIANATGIPHIE--YDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFE 155
            |.::.|..|..:.|.:...:|...:|.:.  :..|:.|.....|:  .:|::.|.   ..:|..:
  Fly   102 VYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLD--FAISMRPD---YHQAIID 161

  Fly   156 IIKSNYEWRTFTLIYETPEGLARLQDL-MNIQALNSDY--VKLRNLADYADDYRILWKETD-ETF 216
            .|: .|.|::...:|::.:||.|||.: ..::..|..:  ..::.:|:.......|....| ..|
  Fly   162 TIQ-YYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRF 225

  Fly   217 HEQRIILDCEPKTLKELLKVSI-DFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKA-NITSVRLK 279
            .::||:|||..:..||::...: |.||.....::.|:.|...|....|:.  :|.| |||..|
  Fly   226 SKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVV--EFGAINITGFR-- 286

  Fly   280 VVDAN-----PFERKKTRL----TKVDQILGNQTMLP------ILIYDAVVLFASSARNVIAAMQ 329
            :||:|     .|...:.||    ....|..|....||      .|:||||.:.. .|.|.|...:
  Fly   287 IVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLV-EAFNRILRKK 350

  Fly   330 P-----FHPPNR-HCGSSS-----------------------PWMLGAFIVNEMKTISEDDVEPH 365
            |     .|...| |.||||                       ||..|..|...::.:..|.:
  Fly   351 PDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGL--- 412

  Fly   366 FKTENMKLDEYGQRIHFNLEIYKPTVN---EPMMVWTPDNGIKKRLLNLELES----------AG 417
              :..::.||.|:||::.|.:.:.:||   :.:..|..|.|:      |.|.|          :.
  Fly   413 --SGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGL------LPLHSHNYASSSRSASA 469

  Fly   418 TTQDFSEQRKVYTVVTHYEEPYFMMKE--DHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVN 480
            :|.|: ::...|.|.:..||||..:|:  ..|:..|.:::|||..||...|:..:...||..:|.
  Fly   470 STGDY-DRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQ 533

  Fly   481 GNGKYNPETKQ----WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPP 541
             :|.|..|.:.    |||::.:||...|.|.:..:|||..|..|:||:.|||.|||||:..|...
  Fly   534 -DGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVK 597

  Fly   542 EPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREW-------------LPP------- 586
            :....|:||.|.:.|:||.:|.:.:.::....|:.|....||             .||
  Fly   598 QTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGAT 662

  Fly   587 --NPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANL 649
              .|....|....|.:.:.||.|..:.:.|||||||.|.....||...:||||.::::|:|||||
  Fly   663 LSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANL 727

  Fly   650 AAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTST 714
            |||||..:..:.||:.:||..|..|::|::..|||..||..|....:.:.|..| :.|......|
  Fly   728 AAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHT 791

  Fly   715 NKEGVARVRKEKGGYAFLMETTSLTY-NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSI 778
            ..||:.|||:.||.||.|:|:....| |....||..::|..|..|.:|:|.|:||..|..|:.::
  Fly   792 YDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAV 856

  Fly   779 LQLSERGELQKMKNKWWKNHNVTCDSYHEVD-GDELSIIELGGVFLVLAGGVLIGVILGIFEF 840
            |.|.|.|||.:::||||.: ...|:...|.. .:|||:..:.|::.:|.||:|:.||:.|.||
  Fly   857 LTLKENGELLRIRNKWWFD-KTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	105/428 (25%)
		ANF_receptor	46..386	CDD:279440	97/394 (25%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	140/398 (35%)
		Lig_chan	556..828	CDD:278489	100/295 (34%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	106/435 (24%)
		ANF_receptor	53..434	CDD:279440	97/398 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	141/404 (35%)
		Lig_chan	612..907	CDD:278489	101/296 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462513
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.740