DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Ir60a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_611901.1	Gene:	Ir60a / 37881	FlyBaseID:	FBgn0034994	Length:	716	Species:	Drosophila melanogaster

Alignment Length:	834	Identity:	145/834 - (17%)
Similarity:	246/834 - (29%)	Gaps:	351/834 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 EGLARLQDLMNIQALN------SDYVKLRNLADY--------------ADDYRILWKETDETFHE 218
            ||.::   |:|....|      .:..::|..:||              ||:|.|:....|.
  Fly    95 EGFSK---LINEAVTNPGPPDREELFQMRVASDYNITNGTEDKGELILADNYVIVVDSVDR---- 152

  Fly   219 QRIILDCEPKTLKELLKVSIDFKLQGPFRNW-----FLTHLDTHNSGLRDIYNEDFKANITSVRL 278
                       ||||:|..|     ...|:|     ||...  ||:..|:             |.
  Fly   153 -----------LKELMKKKI-----VEMRSWNPGARFLVLF--HNATCRN-------------RP 186

  Fly   279 KVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSP 343
            ..|.:|.|:               ..|....::...:|:|:|..|....:..:: .|.:|.
  Fly   187 LGVASNIFK---------------DLMEMFYVHRVALLYANSTMNYNLLVNDYY-SNVNCR---- 231

  Fly   344 WMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQ----RIHFNLEIYKPTVNEPMMVWTPDN-- 402
                  |:|                    :...||    :::.|..:.|.::.:.:..::|.|
  Fly   232 ------ILN--------------------VQSVGQCHDGKLYPNNAVVKASMQDYVSGFSPRNCT 270

  Fly   403 ------------------GIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENF 449
                              |::.|:|.           |.:.|..:.|            ....:.
  Fly   271 FFACSSISAPFVEADCILGLEMRILG-----------FMKNRLKFDV------------NQTCSL 312

  Fly   450 RGREKYEGYA--VDLISKLSELMEFDYEFMIVNGNGKYNPETKQWD---GIIRKLIDHHA-QIGV 508
            ..|.:.:|.|  ..|:.|:.. .|.|:.|      |.|.|:.:..|   |....|.|.|. .|.:
  Fly   313 ESRGEMDGPANWTGLLGKVQN-NECDFVF------GGYYPDNEVADHFWGSDTYLQDAHTWYIKM 370

  Fly   509 CDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFV 573
            .|      ||       |..|..:.|                  |....||           .|:
  Fly   371 AD------RR-------PAWQALVGI------------------FEAYTWI-----------GFI 393

  Fly   574 FIARLSYREW-----LPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQG--CDILPRGPHMRILT 631
            .|..:|:..|     :.|.|.......|..|    |:..:.:...:|:.  |:           |
  Fly   394 LILIISWLFWFTLVMILPEPKYYQQLSLTAI----NALAVTISIAVQERPICE-----------T 443

  Fly   632 GMWWFFALMM-----LSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSL-FFSE 690
            ...:|.||.:     ::|||:.:.|......:...:..|.:::... :.||   |...|. :|..
  Fly   444 TRLFFMALTLYGLNVVATYTSKMIATFQDPGYLHQLDELTEVVAAG-IPFG---GHEESRDWFEN 504

  Fly   691 SNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRK------------------------------- 724
            .:|......:|...:|.|.   |.|.|.|...::
  Fly   505 DDDMWIFNGYNISPEFIPQ---SKNLEAVKWGQRCILSNRMYTMQSPLADVIYAFPNNVFSSPVQ 566

  Fly   725 --EKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGEL 787
              .|.|:.||.|..|:...:               :..|:...:.:|:|.|.:.       ...:
  Fly   567 MIMKAGFPFLFEMNSIIRLM---------------RDVGIFQKIDADFRYNNTY-------LNRI 609

  Fly   788 QKMKNKWWKNHNVTCDSYHEVDGDELSII----ELGGVFLVLAGGVLIGVILGIFEFLWNVQNVA 848
            .||:.::                .|.:|:    .|.|.|.:|..|
  Fly   610 NKMRPQF----------------PETAIVLTTEHLKGPFFILVVG-------------------- 638

  Fly   849 VEERVTPWQA--FKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRSSKEK 900
                 :.|.|  |..|||  :..| |.:.:..|...|:.|.:|....||...||
  Fly   639 -----SCWAALTFIGELI--IHRW-RTQLVSTSEQQDRRSDKRRRRRRRRKPEK 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	45/278 (16%)
		ANF_receptor	46..386	CDD:279440	42/240 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	73/421 (17%)
		Lig_chan	556..828	CDD:278489	53/321 (17%)
Ir60a	NP_611901.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830