Protein Alignment GluRIIA and Ir40a

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 135/698 - (19%)
• Similarity: 253/698 - (36%)
• Gaps: 186/698 - (26%)

  Fly   262 RDIYNEDF-----KANITSVRLKVVD------------ANP-----FERKKTRLTKV-DQILGNQ 303
            |::|.:||     ::|..||.....:            ||.     .:.....|..: |:.||::
  Fly    67 RNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHR 131

  Fly   304 TMLPILIYDA-------VVLFASSARNVIA------AMQPFHPPNRHCGSSSPWMLGAFIVNEMK 355
            ..|.|..:.|       |:.|....|.|:.      |.:.::...|.|..|           :::
  Fly   132 LSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDS-----------QLQ 185

  Fly   356 TISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQ 420
            .::      .:..:|:.|    |||        |.:...:.|:....|
  Fly   186 LVN------WYDGDNLGL----QRI--------PLLPTALSVYANFKG----------------- 215

  Fly   421 DFSEQRKVYTVVTHYEEPYFMMK------EDHENFRGREKYE--------GYAVDLISKLSELME 471
                  :.:.|...:..|:|.:.      |:.|.|...:..|        |....|:..||:.|.
  Fly   216 ------RTFRVPVFHSPPWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMN 274

  Fly   472 FDYEFMIVNG---------NGKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPF 527
            |.::::...|         :||.:.::  :.|.|..|....|...:.|:.::..||..::|:  |
  Fly   275 FRFKYIEAPGRTQGSMRSEDGKDSNDS--FTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--F 335

  Fly   528 MQLGISILHYKSPPEPKNQ-FAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSY---REW----- 583
            ..|..|.......|...|: .|.:.||..::|.::|...:.....|..|..|.|   |.|
  Fly   336 FTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDV 400

  Fly   584 ----------------------LPPNPAI---QDPDELENIWNVNNSTWLMVGSIMQQGCDILPR 623
                                  |.|...:   |.|.:|     .....|..:...::|.|:.|..
  Fly   401 EHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQL-----FQKCIWFTLRLFLKQSCNELHN 460

  Fly   624 GPHMRILTGMWWFFALMMLS-TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFG---SMRGGST 684
            |...:.||.::|..|..:|: .|:|.|.:.......:..|.:||.| :...:|.|   .:...|:
  Fly   461 GYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRL-QAAMIHDGYRLYVEKESS 524

  Fly   685 SLFFSESNDTDYQRAWNQMKD---FNPSAFTSTNKEGVARVRKEKG-GYAFLMETTSLTYNIER- 744
            ||...|:....:::.:..|:.   .:|..|...:.|...::..|.| ..|.|....:|.:|:::
  Fly   525 SLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQY 589

  Fly   745 NCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMK----NKWWKNHNVT---- 801
            ..:..|:.:::..::..:||.:|..:..:|:..::||.|.|.|.||.    .|.::....|
  Fly   590 GSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIYK 654

  Fly   802 -------CDSYHEVDGDELSIIE------LGGVFLVL-AGGVLIGVIL 835
                   .::|...:..:.::|.      |.|.|:.| .|.:..||||
  Fly   655 GSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVIL 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	31/177 (18%)
		ANF_receptor	46..386	CDD:279440	29/159 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	91/439 (21%)
		Lig_chan	556..828	CDD:278489	66/335 (20%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	25/125 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	22/97 (23%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	32/141 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840