DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GluRIIB

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	405/932 - (43%)
Similarity:	599/932 - (64%)	Gaps:	62/932 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FIIIIGFLEGIIALG-GDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP 74
            |::::..   .||.| .:|...|.:||||::.|.::..:|..|..|||.:. ..|:...||||:.
  Fly     6 FLVLLAL---AIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAIN-PALKLDAIKRYVT 66

  Fly    75 TNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS 139
            .:||.:||.|:|:||.:|||||||||||..||||..:.|.|||||:::|...:.:.:|::|||::
  Fly    67 VDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLT 131

  Fly   140 INVAPSLSVLSRAYFEIIKS-NYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYAD 203
            :||||....||.|:.:|:.| .::|::||:.||....|.|||.::..:.|:...:|::.. :..|
  Fly   132 VNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEF-ERGD 195

  Fly   204 DYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNED 268
            |||||||..:.. .|:.::|||....|.:::..||.:.:.|.|.:.|||:||||.||:...|:.|
  Fly   196 DYRILWKRINNA-REKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRD 259

  Fly   269 FKANITSVRLKVVDANP-------FERK-KTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVI 325
            |...:.:||::.....|       |:.. .||.:.    ||:|     |:||::|||.::...:
  Fly   260 FTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSS----LGSQ-----LVYDSIVLFYNALLEI- 314

  Fly   326 AAMQP-FHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKP 389
             :.:| |:.||..||... |..|..:|.:||.|:...|:|.|||:.::::..|||..||||:|.|
  Fly   315 -SQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNP 377

  Fly   390 TVNEPMMVWTPDNGI---------------KKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPY 439
            .::....:|..:..:               :|||.|.|        |||::...|||.|...:||
  Fly   378 IIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKE--------DFSQKPIRYTVATRVGKPY 434

  Fly   440 FMMKEDHE--NFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQWDGIIRKLI 500
            |..:|:.|  ::.|.|::||||||||..|::..:||:.|..|..|  |.|:..|.:||||||:||
  Fly   435 FSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLI 499

  Fly   501 DHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQ 565
            |::||||:|||||||.|||||||||||||||||||.||.||...:.:|||.|:..|||::::.|.
  Fly   500 DNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAM 564

  Fly   566 LIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRIL 630
            :|...|.:|..|:...||..|...:....|.:|||:::|:.||::||::.||||:||||..||:|
  Fly   565 MITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLL 629

  Fly   631 TGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTD 695
            |..||.|||::..||.|.||||:||:|....|.||.||::|:||.||::|||:||::||||||||
  Fly   630 TAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTD 694

  Fly   696 YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHY 760
            .:.|||:|..|.|.|||..|:|||.||:..||.||||||||:|.|.::|||:||||||..|||||
  Fly   695 NRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHY 759

  Fly   761 GLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDS-YHEVDGDELSIIELGGVFLV 824
            |:||||.:|:|:||||.||:|||||||.|::|||:.::..|||| ...:|..:..:..:||:|:|
  Fly   760 GIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVV 824

  Fly   825 LAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMR-ISSSSDKSSSR 888
            |..||::|:::|:.||||:||.::|:|::.|..|.|||..|.::||:.:||:. ...|.|.:|:.
  Fly   825 LIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTG 889

  Fly   889 RSS----GSRRSSKEKSRSKTV 906
            .||    .|..|:|:|.:::.:
  Fly   890 YSSLEQITSASSAKKKKKTRRI 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	140/380 (37%)
		ANF_receptor	46..386	CDD:279440	131/349 (38%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	210/373 (56%)
		Lig_chan	556..828	CDD:278489	145/272 (53%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	140/381 (37%)
		ANF_receptor	41..378	CDD:279440	133/351 (38%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	210/372 (56%)
		Lig_chan	555..822	CDD:278489	142/266 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449680
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900