Protein Alignment GluRIIA and Ir25a

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 887
• Identity: 225/887 - (25%)
• Similarity: 362/887 - (40%)
• Gaps: 203/887 - (22%)

  Fly    76 NDSFLLQQITCELISNGVAAIFGP-------SSKAASDIVAQIANATGIPHI------EYDLK-- 125
            :|:.:|.:..|...:..:.....|       .|..||:.|.....|.|:|.|      :.||:
  Fly    80 SDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQW 144

  Fly   126 --LEATRQEQLNHQMSINVAPSLSVLSRAYFEI-IKSN-------YEWRTFTLIYETPEGLARLQ 180
              |:..:|:.|     :.|.|...::..|...| |..|       |: .:|.:.::....|..:|
  Fly   145 RDLDEAKQKYL-----LQVMPPADIIPEAIRSIVIHMNITNAAILYD-DSFVMDHKYKSLLQNIQ 203

  Fly   181 DLMNIQALNSD--------YVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVS 237
            ....|.|:..|        ..|||||.  .:::.||     .|....|::|        |.:|.:
  Fly   204 TRHVITAIAKDGKREREEQIEKLRNLD--INNFFIL-----GTLQSIRMVL--------ESVKPA 253

  Fly   238 IDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGN 302
            .       |...|..|..|.|.|  :|.::  :.|.|.:.:|.:....: |.:..|.:....|..
  Fly   254 Y-------FERNFAWHAITQNEG--EISSQ--RDNATIMFMKPMAYTQY-RDRLGLLRTTYNLNE 306

  Fly   303 QTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFK 367
            :..|....|     |..:.|:.:...:..        .|..|      ..:|:.::.||.:.. .
  Fly   307 EPQLSSAFY-----FDLALRSFLTIKEML--------QSGAW------PKDMEYLNCDDFQGG-N 351

  Fly   368 TENMKLDEYGQRIHFNLEIYKPTVNEPMMVWT---------PDNG-------------------- 403
            |....||         |..|...:.||....|         |.||
  Fly   352 TPQRNLD---------LRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSS 407

  Fly   404 -----IKKRL--LNLELESAGTTQDFSEQRK------VYTVVTHYEEPYFMMKEDHENFRGREKY 455
                 |.|.:  ||.||    ..:| .||.|      ||.:.|..:.|:.|..|     ...:.|
  Fly   408 VNSKSIGKWISGLNSEL----IVKD-EEQMKNLTADTVYRIFTVVQAPFIMRDE-----TAPKGY 462

  Fly   456 EGYAVDLISKLSELMEFDYEFMIVNGNGKYN--PETKQWDGIIRKLIDHHAQIGVCDLTITQMRR 518
            :||.:|||::::.::.|||....|. :||:.  .|..||:||::||:|..|.||:..:::...|.
  Fly   463 KGYCIDLINEIAAIVHFDYTIQEVE-DGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAERE 526

  Fly   519 SVVDFTVPFMQL-GISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYRE 582
            .|:|||||:..| ||:|: .:.|..|.:.|.||......||: .|.|....|...::|    :..
  Fly   527 IVIDFTVPYYDLVGITIM-MQRPSSPSSLFKFLTVLETNVWL-CILAAYFFTSFLMWI----FDR 585

  Fly   583 WLP----PNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643
            |.|    .|......||.:..:|:....|..:.|:..||....|:....|::...||.|..::::
  Fly   586 WSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIA 650

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTD------------- 695
            :||||||||||.::..:.::||.||.:|.|:.:..:.|.|...:|...::.:
  Fly   651 SYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLN 715

  Fly   696 ---------------------YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKG--GYAFLMETTS 737
                                 |.:.|..|::   :...:|..|.|||||....  |:|||.:.|.
  Fly   716 DSLTAVERSKLAVWDYPVSDKYTKMWQAMQE---AKLPATLDEAVARVRNSTAATGFAFLGDATD 777

  Fly   738 LTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHN--V 800
            :.|....||||..:||:...|.|.:||..||..:...:.:||.|..:.:|:|:|.|||||..  .
  Fly   778 IRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALA 842

  Fly   801 TCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLW 842
            .||. .|...|.:||..:||||:|:..|:.:..|..:||:.|
  Fly   843 KCDK-PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWW 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	75/394 (19%)
		ANF_receptor	46..386	CDD:279440	68/342 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	122/418 (29%)
		Lig_chan	556..828	CDD:278489	90/313 (29%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	81/411 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	121/412 (29%)
		Lig_chan	565..870	CDD:278489	90/313 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462695
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840