DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIA and gria4b

DIOPT Version :9

Sequence 1:NP_523484.2 Gene:GluRIIA / 33788 FlyBaseID:FBgn0004620 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_997917.2 Gene:gria4b / 336069 ZFINID:ZDB-GENE-030131-8013 Length:904 Species:Danio rerio


Alignment Length:950 Identity:303/950 - (31%)
Similarity:476/950 - (50%) Gaps:113/950 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MRL-CPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQA-FREVNNMKFSE 63
            ||: |..::..|..:.|...|...      :.:.:|.:|..|..:...:|..| |....:...||
Zfish     1 MRISCNQLLLLFSCVWGLTMGAFP------SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASE 59

  Fly    64 LRFVTIKRY--MPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKL 126
            ..|..:...  :.|.:||.:....|...|.||.||||...|.:...:.....|..|..|......
Zfish    60 APFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCGALHISLITPSFPT 124

  Fly   127 EATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSD 191
            |...|..|..:.||..| .||:|         .:|:|..|..:|:|..|.:.||.:|.....|..
Zfish   125 EGESQFVLQLRPSIRGA-LLSLL---------DHYDWNRFVFLYDTDRGYSILQAIMEKAGQNGW 179

  Fly   192 YVKLRNLADYAD-DYRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTH 253
            .|....:.::.| .||.|.::.|.. .|:..::|.|.:.|..:|:  ||:...::|       .|
Zfish   180 QVSAICVENFNDASYRQLLEDLDRR-QEKTFVIDLEAERLNNMLEQIVSVGKHVKG-------YH 236

  Fly   254 LDTHNSGLRDIYNEDFK---ANITSVRLKVVD-ANPFERK-KTRLTKVDQILGNQTMLP-----I 308
            ....|.|.:||..|.|.   ||:|..:|  || :||...| ..|..|:||.....:..|     .
Zfish   237 YIMANLGFKDINLERFMHGGANVTGFQL--VDFSNPMVIKLMQRWNKLDQREYPGSDAPPKYTSA 299

  Fly   309 LIYDAVVLFASSARNV-----------IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDV 362
            |.||.|::.|.:.||:           ||.....:|       ::||..|..:...:|.:     
Zfish   300 LTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANP-------AAPWNQGIDMERTLKQV----- 352

  Fly   363 EPHFK--TENMKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLN-----LELESAGT 418
              |.:  |.|::.|.||:|:::.:::::...|.|..:  |   |...|.:|.     |..|::| 
Zfish   353 --HLQGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYW---NDADKLVLTQDHALLPNETSG- 411

  Fly   419 TQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNG 483
                .|.|.| .|.|..|.||.|:|::.|.:.|.|:||||.|||.|::::.:.|.|:..|| .:|
Zfish   412 ----MENRTV-IVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIV-PDG 470

  Fly   484 KY---NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKN 545
            ||   :||||.|:|::.:|:...|:|.|..||||.:|..|:||:.|||.|||||:..|.......
Zfish   471 KYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 535

  Fly   546 QFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPN--------PAIQDPDELENIWNV 602
            .|:||:|.|.|:|:.::||.:.:::....::|.|..||....        |:.|.|:|    :.:
Zfish   536 VFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGTDGLPSDQPPNE----FGI 596

  Fly   603 NNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD 667
            .||.|..:|:.|||||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:|
Zfish   597 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 661

  Fly   668 LIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFL 732
            |.:|..:.:|::..|||..||..|....|::.|:.||...|:.||.|..||||||||.||.||||
Zfish   662 LAKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFL 726

  Fly   733 METTSLTYNIERN-CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWK 796
            :|:|...|..:|. ||..::|..:..|.||:|.|.||..|:.:::::|:|:|:|.|.|:|||||.
Zfish   727 LESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWY 791

  Fly   797 NHNVTCDSYHEVDGDE----LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ 857
            :.. .|.|....:.|:    ||:..:.|||.:|.||:.:.:::.:.||.:..:|.|...::|..:
Zfish   792 DKG-ECGSGGGGEKDKSSQALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRNEAKRMKLTFTE 855

  Fly   858 AFKAELIFALKFWVRKKPMRISSSSDKS-----SSRRSSG 892
            |.:.:...::...|.:....::....|:     |.|:|||
Zfish   856 AMRNKARLSITGSVGENGRVLTPDCPKAVHSGPSLRQSSG 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIIANP_523484.2 PBP1_iGluR_Kainate 33..404 CDD:107377 103/401 (26%)
ANF_receptor 46..386 CDD:279440 96/368 (26%)
PBP2_iGluR_Kainate 426..796 CDD:270432 163/381 (43%)
Lig_chan 556..828 CDD:278489 114/284 (40%)
gria4bNP_997917.2 Periplasmic_Binding_Protein_Type_1 28..398 CDD:324556 104/406 (26%)
PBP2_iGluR_AMPA_GluR4 414..793 CDD:270445 164/384 (43%)
Lig_chan 546..827 CDD:306551 115/285 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170591040
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100167
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.740

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