Protein Alignment GluRIIA and GluRIIC

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 932
• Identity: 401/932 - (43%)
• Similarity: 576/932 - (61%)
• Gaps: 66/932 - (7%)

  Fly    12 IIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSE-LRFV-TIKRYMP 74
            |:::|.:.....:......:|.:||.||::|.|:|..|......:|..:..: :||. .|||..|
  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKP 69

  Fly    75 TNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS 139
            .:.|..:|:..|:||.|||||||||||||||||||.:.|:|||||||:|:..|..:.|:.||||:
  Fly    70 EDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMT 134

  Fly   140 INVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPE--GLARLQDLMNIQALNSDYVKLRNLADYA 202
            :|:.|:.::||:||.:|:: |:.||.||::|:..:  ..||||||:.::.:::|.|::|.. ...
  Fly   135 LNLYPAQAILSKAYADIVQ-NFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKF-HKD 197

  Fly   203 DDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIY-- 265
            ||:|::||...   .|:|::|||||..|.|||..|.:|.|.|.:.:.|||:|:|:...|.::.
  Fly   198 DDFRVMWKSIR---GERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259

  Fly   266 NEDFKANITSVRLKV-VDANPFERKKTRLTKVDQILGN-----QTMLPILIYDAVVLFASSARNV 324
            ||.|..|||:.||.| .|..|:......:|:.|.|:..     :|::..||:||:.|||.|.||.
  Fly   260 NETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNA 324

  Fly   325 IAAMQPFHP-----PNRHC----GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRI 380
                ..|:|     |...|    .....|.:|.::...||..|..: ..:|:|..::.||.||||
  Fly   325 ----SFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVN-NTNFRTSILQFDEDGQRI 384

  Fly   381 HFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKED 445
            .||:|:|.|.....:.:|.|...|.:  ||::::        ::::.:|.|.|....|||...|.
  Fly   385 TFNIEVYDPLDGIGIAIWDPRGQITQ--LNVDVK--------AQKKMIYRVATRIGPPYFSYNET 439

  Fly   446 HE--NFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQWDGIIRKLIDHHAQI 506
            ..  |..|...|:|||||||..::..:.|:|.|:.|...  ||.:.|||||:|||.::|::.|.:
  Fly   440 ARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHM 504

  Fly   507 GVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLA 571
            |:|||||||.|::.|||||||||||:|||.||||...|...|:|.||..||||:::.:..:||..
  Fly   505 GICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFL 569

  Fly   572 FVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWF 636
            ...:||:|..:|..|:|..:||:.|||.|.::|:.||.|.|||..|||||||.|.:|:....||.
  Fly   570 KTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWI 634

  Fly   637 FALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWN 701
            ||:::.::|||||||||||:|.:.||.:|:||..|.||.||::.||||....::||:|.|:.|:|
  Fly   635 FAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFN 699

  Fly   702 QMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPL 766
            .|.:.:|||:|..|.|||.||||.:|.|.||||||:|.|:.|:||||..:||:.|||||.:|||.
  Fly   700 LMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPF 764

  Fly   767 GSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD---ELSIIELGGVFLVLAGG 828
            |::||:||||:||:|||||||..:|.|||||.|.:|  :.|.|.|   :::..||.|:|..|..|
  Fly   765 GAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASC--FEEPDPDATPDMTFEELRGIFYTLYAG 827

  Fly   829 VLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPM----RISS-------SS 882
            :||..::||.|||..||.||:|||:|...|||.|:.|.|..|..:||:    .|||       |.
  Fly   828 ILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSL 892

  Fly   883 DKSSSRRSSGSR-----RSSKE 899
            |||..|....||     |||:|
  Fly   893 DKSLDRTPKSSRRVVIGRSSEE 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	151/392 (39%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	192/373 (51%)
		Lig_chan	555..828	CDD:459656	140/275 (51%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	151/392 (39%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	192/370 (52%)
		Lig_chan	554..827	CDD:459656	140/274 (51%)