DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Ir8a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	216/946 - (22%)
Similarity:	360/946 - (38%)	Gaps:	249/946 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 DLKLEATRQEQ-LNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQ------ 180
            |..|..||.|. |:.|....:..::.  :.|..::..|::| ..:.|:.....|..||:
  Fly    56 DTTLTLTRSEDGLDMQRFCEILSTVG--ASAVIDLTYSHWE-EGYNLVRSLGIGYVRLERIMRPF 117

  Fly   181 -----DLMNIQALNSDYVKLRNLADYAD---------DYRILWKETDET-----FHEQRIILDCE 226
                 |.|..:..|:..:...|..|..:         .:|.|..:..:|     |.|:...|...
  Fly   118 LDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPA 182

  Fly   227 PKTLKELLKVSIDFKLQGPFR------------NWFLTHLDTHNSGLRDIYNEDFKANITSVRLK 279
            |..:....:.:   .:.|.|.            .|....|||     ||   ..||
  Fly   183 PTYIALFARAA---AMNGIFEKVQKADLFQRPLEWHFVFLDT-----RD---RVFK--------- 227

  Fly   280 VVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPW 344
                  :.|:....|:                     |..:.|.:..:| |.  |:.:|||...
  Fly   228 ------YRRQAELCTR---------------------FTLNPRAICRSM-PM--PDLYCGSGFT- 261

  Fly   345 MLGAFIVNEMKT-ISEDDVEPHFK----------------TENMKLDEYG--QRIHF-NLEIYKP 389
            |..|.::|.::: |:...|.|.:.                ::.::.|:|.  ..:|: |...|.|
  Fly   262 MQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAP 326

  Fly   390 ------------------TVNEPMMVWTPDNGIK-----------KRLLNLELESAGTTQDFSEQ 425
                              .||.....::.::..|           .||||         :..|..
  Fly   327 PLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLN---------ETISPA 382

  Fly   426 RKVYTVVTHYEEPYFMMKEDH---ENFRGREK---YEGYAVDLISKLSELMEFDYEFMI--VNGN 482
            |:.:.:.|....|:..::.:.   |..|.|..   :|||.:|.|.:||:.:.|::|.:.  |...
  Fly   383 RRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHM 447

  Fly   483 GKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFM-QLGISILHYKSPPEPKNQ 546
            |:.| |..:|||::..|:.......:..|.:...|..|:||..|:. |.||||. .:.|....:.
  Fly   448 GELN-ELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIA-IRKPVRRTSL 510

  Fly   547 FAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVG 611
            |.|:....:|||: .|.|.|:.|...::... .|..:...|.....|..... :.:..|.|..:.
  Fly   511 FKFMTVLRLEVWL-SIVAALVGTAIMIWFMD-KYSPYSSRNNRQAYPYACRE-FTLRESFWFALT 572

  Fly   612 SIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHF 676
            |...||....|:....|:|...:|.|.::||:|:|||||||||..:.|:.::||:.|..|.::::
  Fly   573 SFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINY 637

  Fly   677 GSMRGGSTSLFFSE---SNDTDYQRAW-----NQMKDF---------------------NPSAFT 712
            ..::...|..:|..   :.||.| |.|     |..|||                     |.|...
  Fly   638 TVVKDSDTHQYFVNMKFAEDTLY-RMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPV 701

  Fly   713 STNKEGVARV-RKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSV 776
            :..|||.|.| ..|...|||:.::..:.|.|.|||:||::||...|:.|.:||..||.....||.
  Fly   702 ADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSY 766

  Fly   777 SILQLSERGELQKMKNKWWKNHNV-TCDSYHEVDGDELSIIELGGVFL-VLAGGVLIGVILGIFE 839
            :||:|.:....:::|.|:|...|: .|....:.:|  :::..|||||: .|.|.||..:.||: |
  Fly   767 AILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEG--ITLESLGGVFIATLFGLVLAMMTLGM-E 828

  Fly   840 FL-----------------------------------------WNVQNVAVEE---RVTPWQAFK 860
            .|                                         |::..:..||   :|:|..:|:
  Fly   829 VLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFE 893

  Fly   861 AELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRS 896
                 ...|..:|.|.||:....|...|....:||:
  Fly   894 -----TATFRGKKLPARITLGDGKFKPRHGLYARRN 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	60/356 (17%)
		ANF_receptor	46..386	CDD:279440	56/320 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	118/408 (29%)
		Lig_chan	556..828	CDD:278489	91/303 (30%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	118/408 (29%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	91/303 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.910