DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GluRIIE

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	292/932 - (31%)
Similarity:	462/932 - (49%)	Gaps:	116/932 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GGDDR----NEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTNDSFLLQQIT 85
            ||.|.    ..:.:|.:..:|.:::.:.||.|....|....:.|  .::|..:...|::......
  Fly    28 GGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSL--TSLKEEVNYGDAYQSYGKL 90

  Fly    86 CELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLS 150
            |.::..|:|.:|||||:..:..:..|.:|..|||| |....|        :....|:.|..:.|:
  Fly    91 CRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHI-YSYMSE--------NAEGFNLHPHPADLA 146

  Fly   151 RAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNI--------------QALNSDYVKLRNLADY 201
            :|.:.:| :.:.|..|..:||:.|.|..|.:|..:              ..||.:|.::......
  Fly   147 KALYSLI-TEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRK 210

  Fly   202 ADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSI---DFKLQGPFRNWFLTHLDTHNSGLRD 263
            :.|.||:...:.||.          |:.|.:..:|.|   |:|       :.:.:||.|:..|.:
  Fly   211 SVDNRIVVVGSSETM----------PEFLNQAQQVGIINEDYK-------YIIGNLDFHSFDLEE 258

  Fly   264 I-YNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQT--------MLPI-----LIYDAV 314
            . |:|   ||||.:||       |..:|..:.::...||..|        ..||     |.||||
  Fly   259 YKYSE---ANITGLRL-------FSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAV 313

  Fly   315 VLFASSARNVIAAMQPFHPPNRHCGSSSPWML--GAFIVNEMKTISEDD---VEPHFKTENMKLD 374
            .|||.:.:|:     ||.|..::|...:..:.  |:...|.|:|:...|   ..|.:...|::
  Fly   314 QLFAQTLKNL-----PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVR-- 371

  Fly   375 EYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDF-----SEQRKVYTVVTH 434
               :..|.::...:|:....:..|..|...:.:.|      |.||..|     |...|.:.::..
  Fly   372 ---KGYHLDVIELQPSGIVKVGTWDEDRQYRPQRL------APTTAQFDSVDNSLANKTFIILLS 427

  Fly   435 Y-EEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN---GKYNPETKQWDGI 495
            . .:||..:.|.::...|..:||||.||||.:|::.:.|::.|  |||.   |.||..|.:..|:
  Fly   428 VPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF--VNGGNDYGSYNKSTNESTGM 490

  Fly   496 IRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIY 560
            :|:::...|.:.:.|||||..|...:|||:|||.|||:||:.|........|.|::||:.|||.:
  Fly   491 LREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWF 555

  Fly   561 MIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGP 625
            :.|:.|.::|:|..:.|||..||..|.|.|::|:||||.:.:.||.|...|:::|||.:|.|:..
  Fly   556 LGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKAL 620

  Fly   626 HMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIE-QDKVHFGSMRGGSTSLFFS 689
            ..|.:...||||.|:::|:||||||||||..|.||.|.|:.||.: :|.|.:|:.:.|||..||.
  Fly   621 STRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFM 685

  Fly   690 ESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQ 754
            .|.:..|:: .|:....||...|..|.|||.|| |....||||||:||:.||.:|.|:|.:||:.
  Fly   686 TSAEERYKK-MNKFMSENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRECNLKKIGDA 748

  Fly   755 IGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNV-TCDSYHEV-DGDELSIIE 817
            :.||.||:|:.....:|...:.::|:|.|:|.|:|||||||..... .|.:..:. |...|.:..
  Fly   749 LDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNN 813

  Fly   818 LGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKF--WVRKKPMRISS 880
            |.|||.||..|....::.||..::..|...|...||....|.|.|..|.:.|  :||   :..:|
  Fly   814 LEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVR---VLKNS 875

  Fly   881 SSDKSSSRRSSGSRRSSKEKSR 902
            :|..|.||:||.|..|..::|:
  Fly   876 ASIYSRSRQSSMSVASVAQESQ 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	95/406 (23%)
		ANF_receptor	46..386	CDD:279440	90/375 (24%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	154/374 (41%)
		Lig_chan	556..828	CDD:278489	116/274 (42%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	94/402 (23%)
		ANF_receptor	51..382	CDD:279440	90/379 (24%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	154/374 (41%)
		Lig_chan	551..824	CDD:278489	116/274 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462599
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.800