Protein Alignment GluRIIA and Nmdar2

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Alignment Length: 950
• Identity: 210/950 - (22%)
• Similarity: 365/950 - (38%)
• Gaps: 233/950 - (24%)

  Fly    28 DRNEITVGAIF-YEN--EKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTNDSFLLQQIT---- 85
            ::.::.:|.|. :.|  ::|...|.:.|...:...:.::|.|:....:...|..|.:..:|
  Fly    97 NKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPT 161

  Fly    86 ------C-ELISNGVAAI--------FGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135
                  | |.:...|:||        ||.|: |::....|:|...|||.|.::.......:....
  Fly   162 AILSTLCKEFLRVNVSAILYMMNNEQFGHST-ASAQYFLQLAGYLGIPVISWNADNSGLERRASQ 225

  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTL-----------IYETPEGLARLQDLMNIQALN 189
            ..:.:.:|||:...|.|...|:: .|:|..|::           :....|.:|.:|:......||
  Fly   226 STLQLQLAPSIEHQSAAMLSILE-RYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILN 289

  Fly   190 -------SDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKT-LKELLKVSIDFKLQGPF 246
                   ||.::|.|                   .|.|::|....:| ...:|:.:.:.||.|..
  Fly   290 SIVVTRTSDLMELVN-------------------SEARVMLLYATQTEAITILRAAEEMKLTGEN 335

  Fly   247 RNWFLT--------------------HLDTHNSGLRD-------IYNEDFKANITSVRLKVVDAN 284
            ..|.::                    |.||.::.|.:       ||:...:|.:|.      .||
  Fly   336 YVWVVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTD------PAN 394

  Fly   285 PFERKKTR-LTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGA 348
            ...|..|: |:..|:..|.        :|...:|....|||
  Fly   395 RDRRLTTQSLSCEDEGRGR--------WDNGEIFFKYLRNV------------------------ 427

  Fly   349 FIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEI--YKPTVNEPMMVWTPDNGIKKRLLNL 411
                        .:|......|::....|......|:|  .:|:.|...:|| .:.|:.|.....
  Fly   428 ------------SIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVW-EEIGVWKSWETQ 479

  Fly   412 ELE---------SAGTTQDFSEQRKVYTVVTHYEE-PYFMMK--------------------EDH 446
            :|:         |....|...|  |.:..:|..|| ||..:.                    .||
  Fly   480 KLDIRDIAWPGNSHAPPQGVPE--KFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADH 542

  Fly   447 E---------NFRGREKYE---GYAVDLISKLSELMEFDYEFMIVNGNGKYNP-ETKQWDGIIRK 498
            |         ..|....|:   |:.:||:.|.:|.:.|.||.:.|. :||:.. |..:|:|:|..
  Fly   543 EMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVE-DGKWGTLENGKWNGLIAD 606

  Fly   499 LIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYK-----SPPEPKNQFAFLEPFAVEVW 558
            |::....:.:..|.|...|.:||||:.|||:.||:|:..|     ||.      ||||||....|
  Fly   607 LVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPT------AFLEPFDTASW 665

  Fly   559 --IYMIFAQLIMTLAFVFIARLSYREWLPPNP-----AIQDPDELENIWNVNNSTWLMVGSIMQQ 616
              :.::..|....:.|:|       |||.|:.     .:|:.:.....:::..:.||:...:.|.
  Fly   666 MLVGIVAIQAATFMIFLF-------EWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQA 723

  Fly   617 GCDI-LPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD--LIEQDKVHFGS 678
            ...: .|||...|.:|.:|..||::.|:.||||||||:.:.:.......|.|  |:.... |..|
  Fly   724 AVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFS-HKPS 787

  Fly   679 MRGGSTSLFFSESNDTDYQRAW-NQMKDFNPSAFTSTNKEGVARVRKEKGGY-AFLMETTSLTYN 741
            .:.|:.....::|....|.... |.|:.:|.::..    :|||.|.  .|.. :|:.:.|.|.|.
  Fly   788 FKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVA----DGVAAVL--NGNLDSFIYDGTVLDYL 846

  Fly   742 I--ERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTC-- 802
            :  :.:|.|..:|.......||||....|.|....:..:|:....|:|::::..|...   ||
  Fly   847 VAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTG---TCRP 908

  Fly   803 DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLW 842
            ........|.|::.:....||:|..|:|:..:|.:.|.::
  Fly   909 GKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	82/441 (19%)
		ANF_receptor	46..386	CDD:279440	73/405 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	111/422 (26%)
		Lig_chan	556..828	CDD:278489	69/287 (24%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	85/462 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	113/429 (26%)
		Lig_chan	665..928	CDD:278489	66/279 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840