DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and Gria4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	934	Identity:	293/934 - (31%)
Similarity:	473/934 - (50%)	Gaps:	88/934 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LCPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQA-FREVNNMKFSELRF 66
            :|..::..|....|...|...      :.:.:|.:|..|..:...:|..| |....:...||..|
  Rat     4 ICRQIVLLFSGFWGLAMGAFP------SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPF 62

  Fly    67 VTIKRY--MPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEAT 129
            ..:...  :.|.:||.:....|...|.||.||||...|.:...:....:|..|..|......|.
  Rat    63 NLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEG- 126

  Fly   130 RQEQLNHQMSINVAPSL--SVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDY 192
                 ..|..:.:.|||  ::||      :..:|||..|..:|:|..|.:.||.:|.....|..:
  Rat   127 -----ESQFVLQLRPSLRGALLS------LLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWH 180

  Fly   193 VKLRNLADYAD-DYRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTHL 254
            |....:.::.| .||.|.:|.|.. .|::.::|||.:.|:.:|:  ||:...::|       .|.
  Rat   181 VSAICVENFNDVSYRQLLEELDRR-QEKKFVIDCEIERLQNILEQIVSVGKHVKG-------YHY 237

  Fly   255 DTHNSGLRDIYNEDF---KANITSVRLKVVDAN-PFERK-KTRLTKVDQ--ILGNQT---MLPIL 309
            ...|.|.:||..|.|   .||:|..:|  ||.| |...| ..|..|:||  ..|::|   ....|
  Rat   238 IIANLGFKDISLERFIHGGANVTGFQL--VDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSAL 300

  Fly   310 IYDAVVLFASSARNV----IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTEN 370
            .||.|::.|.:.|::    |...:..:..:.....::||..|..:...:|.:....:     |.|
  Rat   301 TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGL-----TGN 360

  Fly   371 MKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVT 433
            ::.|.||:|:::.:::::.....|..|  |   |.:.|.:|..::.:.|......|.|.| .|.|
  Rat   361 VQFDHYGRRVNYTMDVFELKSTGPRKVGYW---NDMDKLVLIQDMPTLGNDTAAIENRTV-VVTT 421

  Fly   434 HYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGI 495
            ..|.||.|.|::||.|.|.:|||||.|||.|::::.:...|:..|| .:|||   :.:||.|:|:
  Rat   422 IMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIV-PDGKYGARDADTKIWNGM 485

  Fly   496 IRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIY 560
            :.:|:...|:|.:..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:|:.
  Rat   486 VGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 550

  Fly   561 MIFAQLIMTLAFVFIARLSYREWLPPNPAIQD-----PDELENIWNVNNSTWLMVGSIMQQGCDI 620
            ::||.:.:::....::|.|..||....|  :|     .|:..|.:.:.||.|..:|:.|||||||
  Rat   551 IVFAYIGVSVVLFLVSRFSPYEWHTEEP--EDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI 613

  Fly   621 LPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTS 685
            .||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|||.
  Rat   614 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTK 678

  Fly   686 LFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-CDLT 749
            .||..|....|::.|..|:...||.||.|..||||||||.||.:|||:|:|...|..:|. ||..
  Rat   679 EFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTM 743

  Fly   750 QIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDE-- 812
            ::|..:..|.||:|.|.||..|..:::::|:|:|:|.|.|:|||||.:.. .|.|   ..||.
  Rat   744 KVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS---GGGDSKD 804

  Fly   813 ----LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRK 873
                ||:..:.|||.:|.||:.:.:::.:.||.:..:..|...::|..:|.:.:...::...|.:
  Rat   805 KTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGE 869

  Fly   874 KPMRISSSSDK-----SSSRRSSG 892
            ....::....|     ::.|:|||
  Rat   870 NGRVLTPDCPKAVHTGTAIRQSSG 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	101/394 (26%)
		ANF_receptor	46..386	CDD:279440	94/361 (26%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	160/378 (42%)
		Lig_chan	556..828	CDD:278489	114/283 (40%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	102/399 (26%)
		ANF_receptor	39..380	CDD:279440	94/367 (26%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	161/385 (42%)
		Lig_chan	546..825	CDD:278489	115/284 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740