back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Gria3

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001106213.1	Gene:	Gria3 / 29628	RGDID:	70958	Length:	888	Species:	Rattus norvegicus

Alignment Length:	902	Identity:	280/902 - (31%)
Similarity:	447/902 - (49%)	Gaps:	118/902 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FIIIIGFLEGIIALG---GDDRNEITVGAIFYENEKEIELSFDQAFREVN-NMKFSELRFVTIKR 71
            |.:::|.      ||   |...|.|::|.:|..|..:...:|..|.:..| |...:|..|.....
  Rat    10 FFLVLGL------LGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYH 68

  Fly    72 --YMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQL 134
              ::.:::||.:....|...|.||.||||...:.:.:.:.....|.....:......:|
  Rat    69 VDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDA------ 127

  Fly   135 NHQMSINVAPSL--SVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN 197
            :.|..|.:.|:|  ::||      :...|:|..|..:|:|..|.:.||.:|.....|:..|..|:
  Rat   128 DVQFVIQMRPALKGAILS------LLGYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARS 186

  Fly   198 LADYAD--DYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSG 260
            :.:..|  ::|.:.:|.|.. .|:|.::|||.:.:..:|:..:   :.|.....:  |....|.|
  Rat   187 VGNIKDVQEFRRIIEEMDRR-QEKRYLIDCEVERINTILEQVV---ILGKHSRGY--HYMLANLG 245

  Fly   261 LRDIYNEDFK---ANITSVRLKVVDANP----FERKKTRLTKVDQILGNQTML---PILIYDAVV 315
            ..||..|...   ||||..:: |.:.||    |.::..||.:.:........|   ..|.:||::
  Rat   246 FTDILLERVMHGGANITGFQI-VNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAIL 309

  Fly   316 LFASSARNVIAAMQPFHPPNRHCGSSS--------PWMLGAFIVNEMKTISEDDVEPHFKTENMK 372
            :.|.:.|.:  ..|......|  ||:.        ||..|..|...:|.:....:     |.|::
  Rat   310 VIAEAFRYL--RRQRVDVSRR--GSAGDCLANPAVPWSQGIDIERALKMVQVQGM-----TGNIQ 365

  Fly   373 LDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKK--------RLLNLELESAGTTQDFSEQRKVY 429
            .|.||:|.::.:::|:..|          :|.:|        |.:....:........||.|.:
  Rat   366 FDTYGRRTNYTIDVYEMKV----------SGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTI- 419

  Fly   430 TVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQ 491
            .|.|..|.||.|.|::||...|.|:||||.|||..::::.:...|:..|| |:|||   :||||.
  Rat   420 VVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIV-GDGKYGARDPETKI 483

  Fly   492 WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVE 556
            |:|::.:|:...|.|.|..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|
  Rat   484 WNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 548

  Fly   557 VWIYMIFAQLIMTLAFVFIARLSYREW-------LPPNPAIQDPDELENIWNVNNSTWLMVGSIM 614
            :|:.::||.:.:::....::|.|..||       .|.:|  |.|.:..|.:.:.||.|..:|:.|
  Rat   549 IWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDP--QSPPDPPNEFGIFNSLWFSLGAFM 611

  Fly   615 QQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSM 679
            ||||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::
  Rat   612 QQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTL 676

  Fly   680 RGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIER 744
            ..|||..||..|....|::.|:.||...||.||.|..:|||||||.||.:|||:|:|...|..:|
  Rat   677 DSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQR 741

  Fly   745 N-CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEV 808
            . ||..::|..:..|.||:|.|.||.....:::::|:|:|:|.|.|:|||||.:.. .|.|   .
  Rat   742 KPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS---G 802

  Fly   809 DGDE------LSIIELGGVFLVLAGGVLIGVILGIFEFLW-------------NVQN 846
            .||.      ||:..:.|||.:|.||:.:.:::.:.||.:             |.||
  Rat   803 GGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQN 859

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.