DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIA and Gria2

DIOPT Version :9

Sequence 1:NP_523484.2 Gene:GluRIIA / 33788 FlyBaseID:FBgn0004620 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_001077280.1 Gene:Gria2 / 29627 RGDID:61862 Length:883 Species:Rattus norvegicus


Alignment Length:928 Identity:288/928 - (31%)
Similarity:457/928 - (49%) Gaps:116/928 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKR 71
            :::..:::...|.|:|.  |...|.|.:|.:|.....: |.|   ||| |..::||...|    |
  Rat     4 IMHISVLLSPVLWGLIF--GVSSNSIQIGGLFPRGADQ-EYS---AFR-VGMVQFSTSEF----R 57

  Fly    72 YMPTND------SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATR 130
            ..|..|      ||.:....|...|.||.||||...|.:.:.:........:..|......:.| 
  Rat    58 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT- 121

  Fly   131 QEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKL 195
                 |...|.:.|.   |..|...:|: .|:|..|..:|::..||:.||.:::..|.....|..
  Rat   122 -----HPFVIQMRPD---LKGALLSLIE-YYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTA 177

  Fly   196 RNLADYADD-----YRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTH 253
            .|:.:..:|     ||.|:::. |...|:|:|||||...:.:::.  ::|...::|       .|
  Rat   178 INVGNINNDKKDETYRSLFQDL-ELKKERRVILDCERDKVNDIVDQVITIGKHVKG-------YH 234

  Fly   254 LDTHNSGLR--DIYNEDF-KANITSVRLKVVDANP------FERKKTRLTKVDQILGNQT----M 305
            ....|.|..  |:....| .||::.  .::||.:.      .||..|...|  :..|..|    .
  Rat   235 YIIANLGFTDGDLLKIQFGGANVSG--FQIVDYDDSLVSKFIERWSTLEEK--EYPGAHTATIKY 295

  Fly   306 LPILIYDAVVLFASSARNV----IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF 366
            ...|.||||.:...:.||:    |...:..:..:.....:.||..|..|...:|.:..:.:    
  Rat   296 TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGL---- 356

  Fly   367 KTENMKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNL-ELESAGTTQDFSEQRKV 428
             :.|:|.|:.|:||::.:.|.:...|.|..:  |:.   :.|.::.| ||.|...|...  :.|.
  Rat   357 -SGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE---VDKMVVTLTELPSGNDTSGL--ENKT 415

  Fly   429 YTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETK 490
            ..|.|..|.||.|||::||...|.|:||||.|||.:::::...|.|:..|| |:|||   :.:||
  Rat   416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV-GDGKYGARDADTK 479

  Fly   491 QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAV 555
            .|:|::.:|:...|.|.:..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.
  Rat   480 IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAY 544

  Fly   556 EVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----NIWNVNNSTWLMVGSIMQ 615
            |:|:.::||.:.:::....::|.|..||  .....:|..|.:     |.:.:.||.|..:|:.|:
  Rat   545 EIWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMR 607

  Fly   616 QGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMR 680
            |||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::.
  Rat   608 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLD 672

  Fly   681 GGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN 745
            .|||..||..|....:.:.|..|:...||.|..|..||||||||.||.||:|:|:|...|..:|.
  Rat   673 SGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK 737

  Fly   746 -CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVD 809
             ||..::|..:..|.||:|.|.||.....:::::|:|:|:|.|.|:|||||.:.. .|.|   ..
  Rat   738 PCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS---GG 798

  Fly   810 GDE------LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALK 868
            ||.      ||:..:.|||.:|.||:.:.:::.:.||.:.               .:||   |.:
  Rat   799 GDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK---------------SRAE---AKR 845

  Fly   869 FWVRKKPMRISSSSDKSS 886
            ..|.|.|..|:.||.::|
  Rat   846 MKVAKNPQNINPSSSQNS 863

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIANP_523484.2 PBP1_iGluR_Kainate 33..404 CDD:107377 96/402 (24%)
ANF_receptor 46..386 CDD:279440 90/369 (24%)
PBP2_iGluR_Kainate 426..796 CDD:270432 155/378 (41%)
Lig_chan 556..828 CDD:278489 109/283 (39%)
Gria2NP_001077280.1 PBP1_iGluR_AMPA_GluR2 28..397 CDD:107384 97/407 (24%)
ANF_receptor 56..379 CDD:279440 83/353 (24%)
PBP2_iGluR_AMPA 413..794 CDD:270433 156/384 (41%)
Glutamate binding 499..501 0/1 (0%)
Lig_chan 545..824 CDD:278489 110/284 (39%)