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Protein Alignment GluRIIA and Grik1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001104587.1	Gene:	Grik1 / 29559	RGDID:	2732	Length:	949	Species:	Rattus norvegicus

Alignment Length:	948	Identity:	298/948 - (31%)
Similarity:	475/948 - (50%)	Gaps:	133/948 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKE----IELSFDQAFREVNNMKFSELRFVTIKRYMPTN------------DSFL 80
            :.:|.||...|.|    .||:|..|...:|..          :..||..            |||.
  Rat    37 LRIGGIFETVENEPVNVEELAFKFAVTSINRN----------RTLMPNTTLTYDIQRINLFDSFE 91

  Fly    81 LQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS 145
            ..:..|:.::.||||:||||..::...|..|.||..:|||:...|..:.....|.:   ||:.|.
  Rat    92 ASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDSRDLFY---INLYPD 153

  Fly   146 LSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWK 210
            .:.:|||..::: ..|.|:|.|::||...||.|||:|:...:..:..:|:|.|.....|.:.|.|
  Rat   154 YAAISRAVLDLV-LYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPPANKDAKPLLK 217

  Fly   211 ETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITS 275
            |..:: .|..:|.||..:|..|:||..:...:...:.::|.|.||.....| ::|... ..|:|.
  Rat   218 EMKKS-KEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL-ELYRYS-GVNMTG 279

  Fly   276 VRLKVVDANPF----------------ERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARN- 323
            .||..:| ||.                .|.:|.|     :.|..|....|:||||.:.|.::..
  Rat   280 FRLLNID-NPHVSSIIEKWSMERLQAPPRPETGL-----LDGMMTTEAALMYDAVYMVAIASHRA 338

  Fly   324 ---VIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF---KTENMKLDEYGQRIHF 382
               .::::|        |....||.||...:|.:|....|.:....   ||:.::.|       |
  Rat   339 SQLTVSSLQ--------CHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKD-------F 388

  Fly   383 NLEI-------------------YKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKV 428
            :|:|                   ||  |.:.:.:|..::|:.....|.: .|...|...:.:..:
  Rat   389 DLDIISLKEEGTEKASGEVSKHLYK--VWKKIGIWNSNSGLNMTDGNRD-RSNNITDSLANRTLI 450

  Fly   429 YTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK--Q 491
            .|.:  .||||.|.::..:...|.:::|||.:||:.:||.::.|.|:..:| .:|||..:..  :
  Rat   451 VTTI--LEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLV-PDGKYGAQNDKGE 512

  Fly   492 WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVE 556
            |:|::::||||.|.:.|..||||.:|..|:||:.|||.||||||:.|........|:||.|.:.:
  Rat   513 WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 577

  Fly   557 VWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL 621
            :|:|::.|.|.::.....|||.:..||..|:|...|.|.:||.:.:.||.|..||::||||.:::
  Rat   578 IWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 642

  Fly   622 PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSL 686
            |:....||:.|:||||.|:::|:||||||||||..:.:|.|.|..||.:|.|:.:|::|.|||..
  Rat   643 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMT 707

  Fly   687 FFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQI 751
            ||.:|..:.|::.|..|.....||....:.||:.||...  .||.|||:||:.|..:|||:||||
  Rat   708 FFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTT--DYALLMESTSIEYVTQRNCNLTQI 770

  Fly   752 GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSII 816
            |..|..|.||:..|:||.||..::::||||.|.|:|..||.|||:.:.  |......:...|.:.
  Rat   771 GGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEEDSKEASALGVE 833

  Fly   817 ELGGVFLVLAGGVLIGVILGIFEFLW-NVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISS 880
            .:||:|:|||.|:::.|.:.|.|||: :.:|..||::....:         |:|:.|.| :|...
  Rat   834 NIGGIFIVLAAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSR---------LRFYFRNK-VRFHG 888

  Fly   881 SSDKSSSRR--------------SSGSRRSSKEKSRSK 904
            |..:|....              |..:::..|:|||:|
  Rat   889 SKKESLGVEKCLSFNAIMEELGISLKNQKKLKKKSRTK 926

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.