back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIN2D

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	903	Identity:	194/903 - (21%)
Similarity:	339/903 - (37%)	Gaps:	251/903 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SFLLQQITCELIS----NGVAAIFGPSSK--AASDIVAQIANATGIP----HIEYDLKLEATRQE 132
            |.:||  .|:|:|    :||  :|...|:  |.:.|:..::..|.:|    |....|.|....:.
Human    98 SLVLQ--LCDLLSGLRVHGV--VFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKG 158

  Fly   133 QLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN 197
            ....|:..:....|.|:    ||::: .|:|.:|..:  |.........|..|:.|
Human   159 STFLQLGSSTEQQLQVI----FEVLE-EYDWTSFVAV--TTRAPGHRAFLSYIEVL--------- 207

  Fly   198 LADYADDYRILWKETDETFHEQRIILD-----------------------CEPKTLKELLKVSID 239
                .|...:.|:      |...:.||                       |..:..:.:.:.:.:
Human   208 ----TDGSLVGWE------HRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEE 262

  Fly   240 FKLQGPFRNWFLTH----------------------------LDTHNSGLRDIYNEDFKANITSV 276
            ..|.|....||:..                            ....::|.||.......|.:..|
Human   263 AGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVV 327

  Fly   277 RLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSS 341
                            ......:|.:...||.|.:|.      .|:|           ..|.|.|
Human   328 ----------------ARGAQALLRDYGFLPELGHDC------RAQN-----------RTHRGES 359

  Fly   342 SPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKK 406
                |..:.:|    |:.|:.:..|       :|.|..::.:|.:...|.:.   .|......::
Human   360 ----LHRYFMN----ITWDNRDYSF-------NEDGFLVNPSLVVISLTRDR---TWEVVGSWEQ 406

  Fly   407 RLLNLE----------LESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGR--------- 452
            :.|.|:          |:....||..       ||.|..|.| |::.|..:...|.
Human   407 QTLRLKYPLWSRYGRFLQPVDDTQHL-------TVATLEERP-FVIVEPADPISGTCIRDSVPCR 463

  Fly   453 ----------------EK--YEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRK 498
                            ||  .:|:.:|::.:|:..:.|.|:..:|. |||:..:.. .|:|:|.:
Human   464 SQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVT-NGKHGKKIDGVWNGMIGE 527

  Fly   499 LIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYM 561
            :....|.:.:..|||.:.|..:|||:|||::.|||::..:|  ...|.   |||||::..||:.|
Human   528 VFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMM 589

  Fly   562 IFAQLIMTLAFVFIARLSYREWLPP---NPAI---QDPDELENIWNVNNSTWLMVGSIMQQGCDI 620
            ....|.:....|||.     |:|.|   |.::   :.|.  .:.:.:..|.||:...:......:
Human   590 FVMCLTVVAVTVFIF-----EYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPV 647

  Fly   621 -LPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGS 678
             .|||...:|:..:|.|||::.|::||||||||:...::..::..|.|...|      ..:.||:
Human   648 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGT 712

  Fly   679 MRGGSTSLFFSESNDTD---YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTY 740
            :..|||.... .||..|   |...:||.:          .:|.:.:::..|.. ||:.:...|.|
Human   713 VPNGSTEKNI-RSNYPDMHSYMVRYNQPR----------VEEALTQLKAGKLD-AFIYDAAVLNY 765

  Fly   741 NIERN--CDLTQI--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HN 799
            ...::  |.|..|  |:......||:|:..||.::..:.:::||.....|::.::..|...  ||
Human   766 MARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHN 830

  Fly   800 VTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ 857
               |.. ||...:|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:
Human   831 ---DKI-EVMSSKLDIDNMAGVFYML----LVAMGLSLLVFAW--------EHLVYWR 872

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.