Protein Alignment GluRIIA and GRIN2C

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 927
• Identity: 204/927 - (22%)
• Similarity: 354/927 - (38%)
• Gaps: 242/927 - (26%)

  Fly    75 TNDSFLLQQITCELISNGVAAIFG------PSSKAASDIVAQIANATGIPHIEYD----LKLEAT 129
            ||.|.||.|| |.|:  |.|.:.|      ..::|.:.|:..|::.|.:|.:...    :.|...
Human    72 TNPSSLLTQI-CGLL--GAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPK 133

  Fly   130 RQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVK 194
            .......|:.:::...|.||    |:::: .|:|..|.:|.....|.|..  |..::|:
Human   134 EPGSAFLQLGVSLEQQLQVL----FKVLE-EYDWSAFAVITSLHPGHALF--LEGVRAV------ 185

  Fly   195 LRNLADYADDYRILWKETDETFHE----------QRII--LD-------CEPKTLKELLKVSIDF 240
                   ||...:.|:..|....|          ||::  ||       |..:..:.|...:...
Human   186 -------ADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQA 243

  Fly   241 KLQGPFRNWFLTHL---------DTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKV 296
            .|.||...|.:.:|         .|...||..:..|.::.::              |:|.|
Human   244 GLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSL--------------RQKVR---- 290

  Fly   297 DQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHC----GSSSPWMLGAFIVNEMKTI 357
                           |.|.:.|..|.:..........|...|    |..||
Human   291 ---------------DGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSP-------------- 326

  Fly   358 SEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMV---------------WTPDNGIKKR 407
                ....|....:.:...|:...|:...|   :.:|.||               |  ::|:...
Human   327 ----AREAFYRHLLNVTWEGRDFSFSPGGY---LVQPTMVVIALNRHRLWEMVGRW--EHGVLYM 382

  Fly   408 LLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMM------------------KEDHENFRGRE- 453
            ...:....:.:.|...:.|.: ||.|..|.|:.::                  ::.:..|...:
Human   383 KYPVWPRYSASLQPVVDSRHL-TVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDV 446

  Fly   454 -KY-----EGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDL 511
             .|     :|:.:|::.||:.:::|.|:..:|. |||:....: .|:|:|.::....|.:.:..|
Human   447 APYTKLCCKGFCIDILKKLARVVKFSYDLYLVT-NGKHGKRVRGVWNGMIGEVYYKRADMAIGSL 510

  Fly   512 TITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLA--- 571
            ||.:.|..:|||:|||::.|||::..:|  ...|.   |||||::..||: |:|...:..:|
Human   511 TINEERSEIVDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWV-MMFVMCLTVVAITV 571

  Fly   572 --FVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPRGPHMRILTGM 633
              |.:.:.:||.:.|........|     .:.:..|.||:...:......| .|||...:|:..:
Human   572 FMFEYFSPVSYNQNLTRGKKSGGP-----AFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLV 631

  Fly   634 WWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDL----IE--------------------QDK- 673
            |.|||::.|::||||||||:...::..::..|.|.    :|                    ||:
Human   632 WAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQDQY 696

  Fly   674 --VHFGSMRGGSTSLFFSESN-DTDYQRAWNQMKDFN----PSAFTSTNKEGVARVRKEKGGYAF 731
              ..||::..|||     |.| .::|:.....|..||    ..|.||......|:....|.. ||
Human   697 PPFRFGTVPNGST-----ERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGSEAQPVPRKLD-AF 755

  Fly   732 LMETTSLTY--NIERNCDLTQI--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKN 792
            :.:...|.|  ..:..|.|..|  |:......||:|:...|.::..:.:::||....||.||::.
Human   756 IYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLET 820

  Fly   793 KWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ 857
            .|..  .:..:..:||...:|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:
Human   821 VWLS--GICQNEKNEVMSSKLDIDNMAGVFYML----LVAMGLALLVFAW--------EHLVYWK 871

  Fly   858 -----AFKAELIFALKF 869
                 ...::|.|.|.|
Human   872 LRHSVPNSSQLDFLLAF 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	72/386 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	113/439 (26%)
		Lig_chan	555..828	CDD:459656	79/314 (25%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	72/390 (18%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	113/447 (25%)
		NMDAR2_C	866..>941	CDD:463148	5/23 (22%)