Protein Alignment GluRIIA and GRIN2B

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 203/911 - (22%)
• Similarity: 349/911 - (38%)
• Gaps: 239/911 - (26%)

  Fly    75 TNDSFLLQQITCELISN----GVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135
            |:...::.:| |:|:|:    ||........:|.:.|:..|:..|..|.:...........::..
Human    76 TDPKSIITRI-CDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDE 139

  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN--- 197
            ..|.....||:...:.....|:: .|:|..|:::.....|   .||.:|         |:|:
Human   140 SSMFFQFGPSIEQQASVMLNIME-EYDWYIFSIVTTYFPG---YQDFVN---------KIRSTIE 191

  Fly   198 ------------LADYADDYRILWKETDETFHEQR-------IILDCEPKTLKELLKVSIDFKLQ 243
                        |.|.:.|      :.|.....|.       |:|.|..:....:.:|:....|.
Human   192 NSFVGWELEEVLLLDMSLD------DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250

  Fly   244 GPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPI 308
            |....|.:..|   .:|..|....:|...:.||.....|..                     ||.
Human   251 GYGYTWIVPSL---VAGDTDTVPAEFPTGLISVSYDEWDYG---------------------LPA 291

  Fly   309 LIYDAVVLFASSARNVIAAMQPFHPPNRHCGSS------SPWMLGAFIVNEMKTISEDDVEPHFK 367
            .:.|.:.:..::|.::::.......|...|.::      ...||..:::|..           |:
Human   292 RVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVT-----------FE 345

  Fly   368 TENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE--LESAGTTQDFSEQRKVY- 429
            ..|:...|.|.::|..|.|.                    |||.|  .|..|..:|.|.|.|.|
Human   346 GRNLSFSEDGYQMHPKLVII--------------------LLNKERKWERVGKWKDKSLQMKYYV 390

  Fly   430 ----------------TVVTHYEEPYFMM-------------------------KEDHENFRGRE 453
                            ::||..|.|:.::                         |.|.|....::
Human   391 WPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKK 455

  Fly   454 KYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMR 517
            ..:|:.:|::.|:|:.::|.|:..:|. |||:..:.. .|:|:|.:::...|.:.|..|||.:.|
Human   456 CCKGFCIDILKKISKSVKFTYDLYLVT-NGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEER 519

  Fly   518 RSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----A 576
            ..||||:|||::.|||::..:|  ...|.   ||||||:.:||:.|....||::...||:    :
Human   520 SEVVDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 581

  Fly   577 RLSYREWL-----PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWW 635
            .:.|...|     |..|:          :.:..:.||:.|.:......:. |:|...:|:..:|.
Human   582 PVGYNRCLADGREPGGPS----------FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636

  Fly   636 FFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGSMRGGSTSLFFSESN-D 693
            |||::.|::||||||||:...::...:..|.|...|      ....||::..|||     |.| .
Human   637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST-----ERNIR 696

  Fly   694 TDYQRAWNQMKDFNPSAFTSTNKEGV--ARVRKEKGGY-AFLMETTSLTYNIERN--CDLTQI-- 751
            .:|......|..|        |:.||  |.:..:.|.. ||:.:...|.|...|:  |.|..|
Human   697 NNYAEMHAYMGKF--------NQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGS 753

  Fly   752 GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELS 814
            |:......||:|:...|.::..:.::||||...||:::::..|...  ||    ..:||...:|.
Human   754 GKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHN----EKNEVMSSQLD 814

  Fly   815 IIELGGVFLVLAGGVLIGVILGIFE--FLWN--------------------------VQNVAVEE 851
            |..:.|||.:|...:.:.:|..|.|  |.|.                          :..||:||
Human   815 IDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEE 879

  Fly   852 R 852
            |
Human   880 R 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	60/361 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	114/438 (26%)
		Lig_chan	555..828	CDD:459656	78/298 (26%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	69/386 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	112/426 (26%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		3/18 (17%)
		NMDAR2_C	840..1484	CDD:463148	7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484