DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIN2A

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	941	Identity:	208/941 - (22%)
Similarity:	374/941 - (39%)	Gaps:	218/941 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TNDSFLLQQITCELIS----NGVAAIFGPSS--KAASDIVAQIANATGIP----HIEYDLKLEAT 129
            |:...|:..: |:|:|    :|:  :||..:  :|.:.::..|::.|.:|    |....:.:...
Human   129 TDPKSLITHV-CDLMSGARIHGL--VFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADK 190

  Fly   130 RQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARL--------------Q 180
            .......|...::....:|:.:     |..:|:|..|:|:.....|....              .
Human   191 DPTSTFFQFGASIQQQATVMLK-----IMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGW 250

  Fly   181 DLMNIQALNSDY------VKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSID 239
            |:.|:..|::.:      |:|:.:                  |...|:|.|.......:|..:..
Human   251 DMQNVITLDTSFEDAKTQVQLKKI------------------HSSVILLYCSKDEAVLILSEARS 297

  Fly   240 FKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRL----TKVDQIL 300
            ..|.|....|.:..|   .||..::..::|.:.:.||.....|.:...|.:..:    |....:|
Human   298 LGLTGYDFFWIVPSL---VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSML 359

  Fly   301 GNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPH 365
            ...:.:|    :|..............|...||               |:||    ::.|.
Human   360 EKFSYIP----EAKASCYGQMERPEVPMHTLHP---------------FMVN----VTWDG---- 397

  Fly   366 FKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSE---QRK 427
               :::...|.|.::|..|.:.  .:|:. ..|......:...|:|........:.||:   ...
Human   398 ---KDLSFTEEGYQVHPRLVVI--VLNKD-REWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDN 456

  Fly   428 VYTVVTHYEEPYFMMKED-------------------------HENFRGREKYEGYAVDLISKLS 467
            ..::||..|.| |::.||                         :|....::..:|:.:|::.|||
Human   457 HLSIVTLEEAP-FVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLS 520

  Fly   468 ELMEFDYEFMIVNGNGKYNPETKQ-WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLG 531
            ..::|.|:..:|. |||:..:... |:|:|.:::...|.:.|..|||.:.|..||||:|||::.|
Human   521 RTVKFTYDLYLVT-NGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETG 584

  Fly   532 ISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----ARLSYREWLPPNPAI 590
            ||::..:|  ...|.   ||||||:..||:.|....||::...||:    :.:.|...|....|.
Human   585 ISVMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAP 646

  Fly   591 QDPDELENIWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLSTYTANLAAFLT 654
            ..|.     :.:..:.||:.|.:......:. |:|...:|:..:|.|||::.|::||||||||:.
Human   647 HGPS-----FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMI 706

  Fly   655 SNKWQSSIKSLQDLIEQDKVH-------FGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFT 712
            ..::...:..|.|...| :.|       ||::..|||..  :..|:..|...:          .|
Human   707 QEEFVDQVTGLSDKKFQ-RPHDYSPPFRFGTVPNGSTER--NIRNNYPYMHQY----------MT 758

  Fly   713 STNKEGV--ARVRKEKGGY-AFLMETTSLTYNIERN--CDLTQIGEQ--IGEKHYGLAVPLGSDY 770
            ..|::||  |.|..:.|.. ||:.:...|.|...|:  |.|..||..  .....||:|:..||.:
Human   759 KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPW 823

  Fly   771 RTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGV 833
            :..:.:::||....||:::::..|...  ||    ..:||...:|.|..:.|||.:||..:.:.:
Human   824 KRQIDLALLQFVGDGEMEELETLWLTGICHN----EKNEVMSSQLDIDNMAGVFYMLAAAMALSL 884

  Fly   834 ILGIFE--FLWN--------------------------VQNVAVEER-------VTPWQAFKAEL 863
            |..|:|  |.|.                          :..|.:||:       :|..|:...:|
Human   885 ITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKL 949

  Fly   864 IFALKFWVRKKPMRISSSSDKSSSRRSSGSR 894
            :.:.|        .|||.|:.:|||..|..|
Human   950 LRSAK--------NISSMSNMNSSRMDSPKR 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	59/362 (16%)
		ANF_receptor	46..386	CDD:279440	57/344 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	113/416 (27%)
		Lig_chan	556..828	CDD:278489	78/292 (27%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6205
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.690