Protein Alignment GluRIIA and GRIK5

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 856
• Identity: 261/856 - (30%)
• Similarity: 426/856 - (49%)
• Gaps: 83/856 - (9%)

  Fly    18 LEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTNDSFLLQ 82
            :.|||.:....|.|:.:          .||..|..:...:.|
Human    51 INGIIEVPAKARVEVDI----------FELQRDSQYETTDTM----------------------- 82

  Fly    83 QITCELISNGVAAIFGPSSKAAS-DIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSL 146
               |:::..||.::.||||..|| ..|:.|.....||||:  :..|.|.:.|.....|:::.||.
Human    83 ---CQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK--VGPEETPRLQYLRFASVSLYPSN 142

  Fly   147 SVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKE 211
            ..:|.|...|:|| :.:.:.:||....|.|.||::|:....::.:.:.:|.|.|..|...:|.:.
Human   143 EDVSLAVSRILKS-FNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEI 206

  Fly   212 TDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLD---THNSGLRDIYNEDFKANI 273
            .|:..  ..||:|........:|:.:.:..:...|..:.||.:|   .|..|:    .|| .:||
Human   207 RDDKV--STIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGI----VED-SSNI 264

  Fly   274 TSVRLKVVDANPFERKKTRL--------TKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQP 330
            ....: ...::||..:..|.        .:....|| ..:...|::|||.:..|:.|.:..:.:.
Human   265 LGFSM-FNTSHPFYPEFVRSLNMSWRENCEASTYLG-PALSAALMFDAVHVVVSAVRELNRSQEI 327

  Fly   331 FHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPT--VNE 393
            ...| ..|.|::.|..|..::|.::.:..|.:     |..::.:..|||.::.|.|.:.:  .:.
Human   328 GVKP-LACTSANIWPHGTSLMNYLRMVEYDGL-----TGRVEFNSKGQRTNYTLRILEKSRQGHR 386

  Fly   394 PMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGY 458
            .:.||..:..:......|::..:.|..:     |...|.|..|.||.|.:.:.:...|.|::||:
Human   387 EIGVWYSNRTLAMNATTLDINLSQTLAN-----KTLVVTTILENPYVMRRPNFQALSGNERFEGF 446

  Fly   459 AVDLISKLSELMEFDYEFMIVNGNGKYN-PETK-QWDGIIRKLIDHH-AQIGVCDLTITQMRRSV 520
            .||::.:|:||:.|.|...:|. :|.|. ||.. .|.|::.:||:.. |.:.|...|||..|..|
Human   447 CVDMLRELAELLRFRYRLRLVE-DGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKV 510

  Fly   521 VDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLP 585
            :||:.|||.||||||:..........|:||:||:..||::|:.|.|.::......||||..||..
Human   511 IDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYN 575

  Fly   586 PNPAIQ-DPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANL 649
            |:|.:: .|..|||.:.:.||.|..||..||||.:|:||....|.::|:||.|.|:::|:|||||
Human   576 PHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANL 640

  Fly   650 AAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTST 714
            |||||..:.:..::|..||.:|..:.:|::..|||..||..|....|||.||.|:...||.|..:
Human   641 AAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKS 705

  Fly   715 NKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSIL 779
            .:||:|||...:  ||||:|:|...|:...||:|||||..:..|.||:.:||||.:|..::::||
Human   706 TEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAIL 768

  Fly   780 QLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNV 844
            ||.|...|:.:|.|||:......:..|...|  |.:..:||:|:||..|::|.|.:.:.||:|:.
Human   769 QLQENNRLEILKRKWWEGGRCPKEEDHRAKG--LGMENIGGIFIVLICGLIIAVFVAVMEFIWST 831

  Fly   845 QNVAVEERVTP 855
            :..| |...||
Human   832 RRSA-ESEETP 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	83/384 (22%)
		ANF_receptor	46..386	CDD:279440	80/351 (23%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	152/373 (41%)
		Lig_chan	556..828	CDD:278489	111/272 (41%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	88/401 (22%)
		ANF_receptor	42..379	CDD:279440	86/381 (23%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	152/378 (40%)
		Lig_chan	546..816	CDD:278489	111/273 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750