DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIK4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	809	Identity:	247/809 - (30%)
Similarity:	406/809 - (50%)	Gaps:	74/809 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 CELISNGVAAIFGPSSK-AASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVL 149
            |:::..||.|:.||||. |:|.|::.|.....:||  :.:..|...:.|.....::|:.||.:.:
Human    84 CQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFVKFQFQRFTTLNLHPSNTDI 146

  Fly   150 SRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDE 214
            |.|...|: :.:...|..||....|.|..|:.|:....::.|.:.:|.|.|..|...:|.:..|:
Human   147 SVAVAGIL-NFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDD 210

  Fly   215 TFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLK 279
              ....||:.........:|..:.:..:...:..:..|:|:.....:..:.::         |:.
Human   211 --KTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDD---------RVN 264

  Fly   280 VVDANPFERKKTRLTKVDQILGNQT--------------MLPILIYDAVVLFASSARNVIAAMQP 330
            ::..:.|.:......:..|.| ||:              :...|::|||..       |:.|:|.
Human   265 ILGFSIFNQSHAFFQEFAQSL-NQSWQENCDHVPFTGPALSSALLFDAVYA-------VVTAVQE 321

  Fly   331 FHPPNR---------HCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEI 386
            .   ||         .|||:..|..|..::|.::.:..:.:..|     ::.:..|||.::.|:|
Human   322 L---NRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGH-----IEFNSKGQRSNYALKI 378

  Fly   387 YKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQDFSEQ--RKVYTVVTHYEEPYFMMKEDHE 447
            .:.|.|....:  |....|       |.::|.....:.|:.  .....|.|..|.||.|:|.:|:
Human   379 LQFTRNGFRQIGQWHVAEG-------LSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQ 436

  Fly   448 NFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYN-PETK-QWDGIIRKLIDHHAQIGVCD 510
            ...|.::|||:.||::.:|:|::.|:|:..:| |:|.|. ||.. .|.|::.:||...|.:.|..
Human   437 EMEGNDRYEGFCVDMLKELAEILRFNYKIRLV-GDGVYGVPEANGTWTGMVGELIARKADLAVAG 500

  Fly   511 LTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI 575
            ||||..|..|:||:.|||.||||||:..........|:||:||:..||::|:.|.|.::.....:
Human   501 LTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565

  Fly   576 ARLSYREWLPPNPAIQDP-DELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFAL 639
            |||:..||..|:|..|.. :.|.|.:::.||.|..||..||||..|.||....|.::|:||.|.|
Human   566 ARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTL 630

  Fly   640 MMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMK 704
            :::|:||||||||||..:....|:|:.||.:|..:.:|::.|||:..||..|....|||.||.|.
Human   631 IIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMY 695

  Fly   705 DFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSD 769
            ...||.|..:.:||:|||.  ...||||:|:|...|..:|||:|||||..:..|.||:.:|:||.
Human   696 SKQPSVFVKSTEEGIARVL--NSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSV 758

  Fly   770 YRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVI 834
            :|....::||||.|...|:.:|.|||:......:..|...|  |.:..:||:|:||..|:::.:.
Human   759 FRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKG--LGMENIGGIFVVLICGLIVAIF 821

  Fly   835 LGIFEFLWNVQNVAVEERVTPWQAFKAEL 863
            :.:.||||.:::....| |:..|....||
Human   822 MAMLEFLWTLRHSEATE-VSVCQEMVTEL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	71/343 (21%)
		ANF_receptor	46..386	CDD:279440	67/323 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	153/372 (41%)
		Lig_chan	556..828	CDD:278489	110/272 (40%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	73/352 (21%)
		ANF_receptor	43..382	CDD:279440	68/327 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	153/372 (41%)
		Lig_chan	547..816	CDD:278489	110/272 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750