DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIK3

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	900	Identity:	278/900 - (30%)
Similarity:	463/900 - (51%)	Gaps:	94/900 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIF-YEN--EKEIELSFDQAFR---EVNNMKFSELRFVTIK---RYMPTNDSFLLQQITCE 87
            |.:|.|| |.:  ..::..:.:.|||   .:.|...:.|...|:.   :.:..:|||...:..|:
Human    36 IRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACD 100

  Fly    88 LISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS------INVAPSL 146
            .::.||.||||||..:.::.|..|.||..:|||:...|         :|.:.      :|:.|..
Human   101 QLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWK---------HHPLDNKDTFYVNLYPDY 156

  Fly   147 SVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKE 211
            :.||.|..:::: ..:||:.|::|:...||.|||:|:...:..:..:|:|.|...:||.|.|.||
Human   157 ASLSHAILDLVQ-YLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKE 220

  Fly   212 TDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK---ANI 273
            . :...|.|||.||......::||.::...:...:.::..|.||.:...|     |.::   .|:
Human   221 M-KRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDL-----EPYRYSGVNL 279

  Fly   274 TSVRLKVVDANP----------FERKKTRLTKVDQILGNQTML-PILIYDAV----VLFASSARN 323
            |..|:..|| ||          .||.:........:|....|. ..|:||||    |.:..:.:.
Human   280 TGFRILNVD-NPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQM 343

  Fly   324 VIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF---KTENMKLDEYGQRIHFNLE 385
            .:.::|        |.....|..|...:|.:|....:.:....   ||..::.|       |:|:
Human   344 TVNSLQ--------CHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTD-------FDLD 393

  Fly   386 I--YKPTVNEPMMVWTPDNGIKKRLLNLELESAG----TTQDFSEQRKVYTVVTHYEEPYFMMKE 444
            |  .|....|.:.||:|.:|     ||:...:.|    .|...:.:..:.|.|  .|||:.|.::
Human   394 IISLKEDGLEKVGVWSPADG-----LNITEVAKGRGPNVTDSLTNRSLIVTTV--LEEPFVMFRK 451

  Fly   445 DHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK--QWDGIIRKLIDHHAQIG 507
            ......|.:::|||.:||:.:|:.::.|.||..:|. :|||..:..  ||:|::::||||.|.:.
Human   452 SDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVE-DGKYGAQDDKGQWNGMVKELIDHKADLA 515

  Fly   508 VCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAF 572
            |..||||.:|...:||:.|||.||:|||:.|......:.|:||.|.:.::|:|::.|.|.::...
Human   516 VAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVL 580

  Fly   573 VFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFF 637
            ..|||.|..||...:|.....:.:||.:.:.||.|..:||:||||.:::|:....||:.|:||||
Human   581 FVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFF 645

  Fly   638 ALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQ 702
            .|:::|:||||||||||..:.:|.|.|..||.:|.|:.:|:::.|:|..||.:|..:.:::.|..
Human   646 TLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAF 710

  Fly   703 MKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLG 767
            |.. .|||....|:||:.|..  ...||.|||:|::.|..:|||:|||||..|..|.||:..|:|
Human   711 MSS-KPSALVKNNEEGIQRAL--TADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMG 772

  Fly   768 SDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIG 832
            |.||..::::||||.|..:|..||.|||:...  |......:...|.|.::||:|:|||.|:::.
Human   773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSG--CPEEENKEASALGIQKIGGIFIVLAAGLVLS 835

  Fly   833 VILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKK-----PMRISSSS 882
            |::.:.||::.::..|..|:.:.......|:.|:|....|.|     ||.:.:.:
Human   836 VLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDA 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	102/408 (25%)
		ANF_receptor	46..386	CDD:279440	92/372 (25%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	147/371 (40%)
		Lig_chan	556..828	CDD:278489	108/271 (40%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	106/417 (25%)
		ANF_receptor	55..398	CDD:279440	93/374 (25%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	147/373 (39%)
		Lig_chan	564..832	CDD:278489	108/272 (40%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650