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Protein Alignment GluRIIA and GRIK1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	944	Identity:	297/944 - (31%)
Similarity:	479/944 - (50%)	Gaps:	125/944 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKE----IELSFDQAFREVNNMKFSELRFVTIKRYMPTN------------DSFL 80
            :.:|.||...|.|    .||:|..|...:|..          :..||..            |||.
Human    37 LRIGGIFETVENEPVNVEELAFKFAVTSINRN----------RTLMPNTTLTYDIQRINLFDSFE 91

  Fly    81 LQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS 145
            ..:..|:.::.||||:||||..::...|..|.||..:|||:...|..:...:.|.:   ||:.|.
Human    92 ASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFY---INLYPD 153

  Fly   146 LSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWK 210
            .:.:|||..::: ..|.|:|.|::||...||.|||:|:...:..:..:|:|.|.....|.:.|.|
Human   154 YAAISRAILDLV-LYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLK 217

  Fly   211 ETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITS 275
            |..:. .|..:|.||..:|..|:||..:...:...:.::|.|.||.....| ::|... ..|:|.
Human   218 EMKKG-KEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL-ELYRYS-GVNMTG 279

  Fly   276 VRLKVVDANPF----------------ERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARN- 323
            .||..:| ||.                .|.:|.|     :.|..|....|:||||.:.|.::..
Human   280 FRLLNID-NPHVSSIIEKWSMERLQAPPRPETGL-----LDGMMTTEAALMYDAVYMVAIASHRA 338

  Fly   324 ---VIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF---KTENMKLDEYGQRIHF 382
               .::::|        |....||.||...:|.:|....|.:..|.   ||..::.|       |
Human   339 SQLTVSSLQ--------CHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKD-------F 388

  Fly   383 NLEI-------------------YKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKV 428
            :|:|                   ||  |.:.:.:|..::|:.....|.: :|:..|...:.:..:
Human   389 DLDIISLKEEGTEKAAGEVSKHLYK--VWKKIGIWNSNSGLNMTDSNKD-KSSNITDSLANRTLI 450

  Fly   429 YTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK--Q 491
            .|.:  .||||.|.::..:...|.:::|||.:||:.:||.::.|.|:..:| .:|||..:..  :
Human   451 VTTI--LEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLV-PDGKYGAQNDKGE 512

  Fly   492 WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVE 556
            |:|::::||||.|.:.|..||||.:|..|:||:.|||.||||||:.|........|:||.|.:.:
Human   513 WNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPD 577

  Fly   557 VWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL 621
            :|:|::.|.|.::.....|||.:..||..|:|...|.|.:||.:.:.||.|..||::||||.:::
Human   578 IWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 642

  Fly   622 PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSL 686
            |:....||:.|:||||.|:::|:||||||||||..:.:|.|.|..||.:|.|:.:|::|.|||..
Human   643 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMT 707

  Fly   687 FFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQI 751
            ||.:|..:.|::.|..|.....:|....:.||:.||...  .||.|||:||:.|..:|||:||||
Human   708 FFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTT--DYALLMESTSIEYVTQRNCNLTQI 770

  Fly   752 GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSII 816
            |..|..|.||:..|:||.||..::::||||.|.|:|..||.|||:.:.  |......:...|.:.
Human   771 GGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEEDNKEASALGVE 833

  Fly   817 ELGGVFLVLAGGVLIGVILGIFEFLW-NVQNVAVEERVTPWQAFKAELIF--ALKFWVRKKPMRI 878
            .:||:|:|||.|:::.|.:.|.||:: :.:|..:|::   .::.:....|  .::|..|||.
Human   834 NIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQK---GKSSRIRFYFRNKVRFHGRKKQ--- 892

  Fly   879 SSSSDKSSSRR--------SSGSRRSSKEKSRSK 904
            |...:|..|..        |..:::..|:|||:|
Human   893 SLGVEKCLSFNAIMEELGISLKNQKKIKKKSRTK 926

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.