DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRID1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	893	Identity:	221/893 - (24%)
Similarity:	394/893 - (44%)	Gaps:	141/893 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREV---NNMKFSELRFVTIKRYMPTNDSFLLQQITCELISNGV 93
            |.:||||.||..:.:..|..|..::   :::..||....:|| .:..|:.|...|..|:|::.|:
Human    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIK-VIEANNPFQAVQEACDLMTQGI 87

  Fly    94 AAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS-----LSVLSRAY 153
            .|:...:..|:::.:..:.:|..|||      |...|....:.:.:.::.||     .::.||..
Human    88 LALVTSTGCASANALQSLTDAMHIPH------LFVQRNPGGSPRTACHLNPSPDGEAYTLASRPP 146

  Fly   154 FEI------IKSNYEWRTFTLIYETPEGLARLQDLM----------NIQALNSDY---------- 192
            ..:      :.:...|:.|.:.|::...:..||..:          ::|.::.:.
Human   147 VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTT 211

  Fly   193 VKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTH 257
            :|...|..|.|..|             |.||...|:.....:..:::..|.....:|...:.:..
Human   212 MKTEELNRYRDTLR-------------RAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEIS 263

  Fly   258 NSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLT-KVDQIL-----GNQTMLPI---LIYDA 313
            :..:.|:.:... ..:|.|| ::..:....:|.||.. ::..:|     |...||.|   .:||:
Human   264 DPEILDLVHSAL-GRMTVVR-QIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDS 326

  Fly   314 VVLFASSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFIVNEMKTISEDDVEPHFK--TENMKLD 374
            |::.|::....:...:.....:.:|  .|:.||..|..:::.:|       :.|..  |..|:..
Human   327 VLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK-------KGHITGLTGVMEFR 384

  Fly   375 EYGQRIHFNLEIYKPTVNE-------PMMVWTPDNGIK---------KRLLNLELESAGTTQDFS 423
            |.....:...||...|.:|       .:..|..:.|:.         .||..|.|:
Human   385 EDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLK--------- 440

  Fly   424 EQRKVYTVVTHYEEPYFMMKEDHENFRGREK-YEGYAVDLISKLSELMEFDYE-FMIVNGNGKYN 486
                   |||..|||:.|:.   ||..|:.| |:|:::|::..|::.:.|.|| :...:|...:.
Human   441 -------VVTVLEEPFVMVA---ENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQ 495

  Fly   487 PETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLE 551
            .....|:|:|.:||...|.:.:..:|||..|.|||||:..:|...:.|| .|.|.|..:.|:...
Human   496 LHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL-IKKPEEKISIFSLFA 559

  Fly   552 PFAVEVWIYMIFA-QLIMTLAFVF--IARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSI 613
            ||...||..:..| .::..|.||.  |..:..:....|.|:...        .::::.|::.|:.
Human   560 PFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA--------TLHSAIWIVYGAF 616

  Fly   614 MQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGS 678
            :|||.:.......|||:.|.||.|.|::.|:||||||||||.::..:.|::.|||.:|.::.:|:
Human   617 VQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGT 681

  Fly   679 MRGGSTSLFFSE------SNDTDYQRAWNQM-KDFNPSAFTSTNKEGVARVRKEKGGYAFLMETT 736
            :|..:...:|..      ..|:.:...|..: |:.......|:..||:.:.:  ||.||||.:..
Human   682 VRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAK--KGNYAFLWDVA 744

  Fly   737 SLTYN--IERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHN 799
            .:.|.  .:.:|.:|.||..|..|.||:|:..||.||...|..||:|.:.|:|..:|.|||. |.
Human   745 VVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWP-HM 808

  Fly   800 VTCD-SYH---EVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWN 843
            ..|| :.|   :.||..|.:....|||.:||.|:|:..::...|..||
Human   809 GRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	78/424 (18%)
		ANF_receptor	46..386	CDD:279440	67/386 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	119/383 (31%)
		Lig_chan	556..828	CDD:278489	89/287 (31%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		82/440 (19%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	79/426 (19%)
		ANF_receptor	41..400	CDD:279440	69/387 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	121/399 (30%)
		Lig_chan	564..841	CDD:278489	89/287 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740