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Protein Alignment GluRIIA and GRIA4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	904	Identity:	290/904 - (32%)
Similarity:	466/904 - (51%)	Gaps:	76/904 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NEITVGAIFYENEKEIELSFDQA-FREVNNMKFSELRFVTIKRY--MPTNDSFLLQQITCELISN 91
            :.:.:|.:|..|..:...:|..| |....:...||..|..:...  :.|.:||.:....|...|.
Human    25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSR 89

  Fly    92 GVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSL--SVLSRAYF 154
            ||.||||...|.:...:....:|..|..|......|.      ..|..:.:.|||  ::||
Human    90 GVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEG------ESQFVLQLRPSLRGALLS---- 144

  Fly   155 EIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYAD-DYRILWKETDETFHE 218
              :..:|||..|..:|:|..|.:.||.:|.....|..:|....:.::.| .||.|.:|.|.. .|
Human   145 --LLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRR-QE 206

  Fly   219 QRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDF---KANITSVRL 278
            ::.::|||.:.|:.:|:  ||:...::|       .|....|.|.:||..|.|   .||:|..:|
Human   207 KKFVIDCEIERLQNILEQIVSVGKHVKG-------YHYIIANLGFKDISLERFIHGGANVTGFQL 264

  Fly   279 KVVDAN-PFERK-KTRLTKVDQ--ILGNQT---MLPILIYDAVVLFASSARNV----IAAMQPFH 332
              ||.| |...| ..|..|:||  ..|::|   ....|.||.|::.|.:.|::    |...:..:
Human   265 --VDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGN 327

  Fly   333 PPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMV 397
            ..:.....::||..|..:...:|.:....:     |.|::.|.||:|:::.:::::.....|..|
Human   328 AGDCLANPAAPWGQGIDMERTLKQVRIQGL-----TGNVQFDHYGRRVNYTMDVFELKSTGPRKV 387

  Fly   398 --WTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAV 460
              |   |.:.|.:|..::.:.|......|.|.| .|.|..|.||.|.|::||.|.|.:|||||.|
Human   388 GYW---NDMDKLVLIQDVPTLGNDTAAIENRTV-VVTTIMESPYVMYKKNHEMFEGNDKYEGYCV 448

  Fly   461 DLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVD 522
            ||.|::::.:...|:..|| .:|||   :.:||.|:|::.:|:...|:|.:..||||.:|..|:|
Human   449 DLASEIAKHIGIKYKIAIV-PDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVID 512

  Fly   523 FTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPN 587
            |:.|||.|||||:..|........|:||:|.|.|:|:.::||.:.:::....::|.|..||....
Human   513 FSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEE 577

  Fly   588 PAIQD-----PDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTA 647
            |  :|     .|:..|.:.:.||.|..:|:.|||||||.||....||:.|:||||.|:::|:|||
Human   578 P--EDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 640

  Fly   648 NLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFT 712
            |||||||..:..|.|:|.:||.:|.::.:|::..|||..||..|....|::.|..|:...||.||
Human   641 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFT 705

  Fly   713 STNKEGVARVRKEKGGYAFLMETTSLTYNIERN-CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSV 776
            .|..||||||||.||.:|||:|:|...|..:|. ||..::|..:..|.||:|.|.||..||.:::
Human   706 RTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNL 770

  Fly   777 SILQLSERGELQKMKNKWWKNHNVTC---DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIF 838
            ::|:|||.|.|.|:|||||.:.. .|   ||..:.....||:..:.|||.:|.||:.:.:::.:.
Human   771 AVLKLSEAGVLDKLKNKWWYDKG-ECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALI 834

  Fly   839 EFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSDK-----SSSRRSSG 892
            ||.:..:..|...::|..:|.:.:...::...|.:....::....|     ::.|:|||
Human   835 EFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSG 893

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.