back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIA2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	922	Identity:	287/922 - (31%)
Similarity:	459/922 - (49%)	Gaps:	104/922 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKR 71
            :::..:::...|.|:|.  |...|.|.:|.:|.....: |.|   ||| |..::||...|    |
Human     4 IMHISVLLSPVLWGLIF--GVSSNSIQIGGLFPRGADQ-EYS---AFR-VGMVQFSTSEF----R 57

  Fly    72 YMPTND------SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATR 130
            ..|..|      ||.:....|...|.||.||||...|.:.:.:........:..|......:.|
Human    58 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT- 121

  Fly   131 QEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKL 195
                 |...|.:.|.   |..|...:|: .|:|..|..:|::..||:.||.:::..|.....|..
Human   122 -----HPFVIQMRPD---LKGALLSLIE-YYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTA 177

  Fly   196 RNLADYADD-----YRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTH 253
            .|:.:..:|     ||.|:::. |...|:|:|||||...:.:::.  ::|...::|       .|
Human   178 INVGNINNDKKDEMYRSLFQDL-ELKKERRVILDCERDKVNDIVDQVITIGKHVKG-------YH 234

  Fly   254 LDTHNSGLR--DIYNEDF-KANITSVRLKVVD-----ANPFERKKTRLTKVDQILGNQTML---P 307
            ....|.|..  |:....| .||::.  .::||     .:.|..:.:.|.:.:....:.|.:   .
Human   235 YIIANLGFTDGDLLKIQFGGANVSG--FQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTS 297

  Fly   308 ILIYDAVVLFASSARNV----IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKT 368
            .|.||||.:...:.||:    |...:..:..:.....:.||..|..|...:|.:..:.:     :
Human   298 ALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGL-----S 357

  Fly   369 ENMKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNL-ELESAGTTQDFSEQRKVYT 430
            .|:|.|:.|:||::.:.|.:...|.|..:  |:.   :.|.::.| ||.|...|...  :.|...
Human   358 GNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE---VDKMVVTLTELPSGNDTSGL--ENKTVV 417

  Fly   431 VVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQW 492
            |.|..|.||.|||::||...|.|:||||.|||.:::::...|.|:..|| |:|||   :.:||.|
Human   418 VTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV-GDGKYGARDADTKIW 481

  Fly   493 DGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEV 557
            :|::.:|:...|.|.:..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:
Human   482 NGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEI 546

  Fly   558 WIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----NIWNVNNSTWLMVGSIMQQG 617
            |:.::||.:.:::....::|.|..||  .....:|..|.:     |.:.:.||.|..:|:.||||
Human   547 WMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQG 609

  Fly   618 CDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGG 682
            |||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|
Human   610 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSG 674

  Fly   683 STSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-C 746
            ||..||..|....:.:.|..|:...||.|..|..||||||||.||.||:|:|:|...|..:|. |
Human   675 STKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPC 739

  Fly   747 DLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWW--KNHNVTCDSYHEVD 809
            |..::|..:..|.||:|.|.||..||.:::::|:|||:|.|.|:|||||  |......||..:..
Human   740 DTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEK 804

  Fly   810 GDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKK 874
            ...||:..:.|||.:|.||:.:.:::.:.||.:.               .:||   |.:..|.|.
Human   805 TSALSLSNVAGVFYILVGGLGLAMLVALIEFCYK---------------SRAE---AKRMKVAKN 851

  Fly   875 PMRISSSSDKSS 886
            ...|:.||.::|
Human   852 AQNINPSSSQNS 863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.