Protein Alignment GluRIIA and GRIA1

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 885
• Identity: 259/885 - (29%)
• Similarity: 433/885 - (48%)
• Gaps: 130/885 - (14%)

  Fly    76 NDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSI 140
            :|||.:....|...|.||.||||...:...:::.....|..:..|.....::.      ::|..:
Human    75 SDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT------SNQFVL 133

  Fly   141 NVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADD- 204
            .:.|.   |..|...|| .:|:|:.|..||:...||:.||.:::..|..:..|...|:....::
Human   134 QLRPE---LQDALISII-DHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEG 194

  Fly   205 YRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDF 269
            ||:|:::.::. .|:.:::|||.:.|..:|...|..:..|...::.|.:|     |..||....|
Human   195 YRMLFQDLEKK-KERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANL-----GFMDIDLNKF 253

  Fly   270 K---ANITSVRL---------------KVVDANPFER---KKTRLTKVDQILGNQTMLPILIYDA 313
            |   ||:|..:|               |..||....|   |:.:.|..            |.||.
Human   254 KESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSA------------LTYDG 306

  Fly   314 VVL----FASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLD 374
            |.:    |.|..|..|...:..:..:.....:.||..|..|...::.:..:.:     |.|::.:
Human   307 VKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGL-----TGNVQFN 366

  Fly   375 EYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKK--------RLLNLELESAGTTQDFSEQRKVYTV 431
            |.|:|.::.|.:          :....:||:|        :.:....::.....:.|.|.:.|.|
Human   367 EKGRRTNYTLHV----------IEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIV 421

  Fly   432 VTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWD 493
            .|..|:||.|:|::...|.|.::||||.|:|.:::::.:.:.|...||: :|||   :|:||.|:
Human   422 TTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVS-DGKYGARDPDTKAWN 485

  Fly   494 GIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVW 558
            |::.:|:...|.:.|..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:|
Human   486 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW 550

  Fly   559 IYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----------NIWNVNNSTWLMVGS 612
            :.::||.:.:::....::|.|..||        ..:|.|           |.:.:.||.|..:|:
Human   551 MCIVFAYIGVSVVLFLVSRFSPYEW--------HSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGA 607

  Fly   613 IMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFG 677
            .|||||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|
Human   608 FMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYG 672

  Fly   678 SMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNI 742
            ::..|||..||..|....:::.|..||...||.|..|.:||:.||||.||.||:|:|:|...|..
Human   673 TLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIE 737

  Fly   743 ERN-CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYH 806
            :|. ||..::|..:..|.||:|.|.||..|..:::::|:|:|:|.|.|:|||||.:.. .|.|
Human   738 QRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS-- 799

  Fly   807 EVDGDE------LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEER---VTPWQAFKAE 862
             ..||.      ||:..:.|||.:|.||:.:.:::.:.||.:..::.:...:   :.|.|:.
Human   800 -GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSI--- 860

  Fly   863 LIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRSSKEKSR 902
                      .:.:|.|:....|.:..|||   .|.|..|
Human   861 ----------NEAIRTSTLPRNSGAGASSG---GSGENGR 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	78/354 (22%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	151/384 (39%)
		Lig_chan	555..828	CDD:459656	110/290 (38%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	80/369 (22%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	152/390 (39%)