DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Grin2c

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	981	Identity:	211/981 - (21%)
Similarity:	384/981 - (39%)	Gaps:	253/981 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IIIIGFLEGIIALG-GDDRNEITVGAIF---------------YENEKEIELSFDQAFREVNNMK 60
            :::...|.....|| |.....:||..:|               .:|..::.|........|||
  Rat    22 LLLTSLLGAWARLGAGQGEQAVTVAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNN-- 84

  Fly    61 FSELRFVTIKRYMPTNDSFLLQQITCELISNGVAAIFG------PSSKAASDIVAQIANATGIPH 119
                          ||.|.:|.|| |.|:  |.|.:.|      ..::|.:.::..:::.|.:|.
  Rat    85 --------------TNPSSILTQI-CGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPI 132

  Fly   120 IEYD----LKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQ 180
            :...    :.|..........|:.:::...|.||    |:::: .|:|..|.:|.....|.|..
  Rat   133 LSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVL----FKVLE-EYDWSAFAVITSLHPGHALF- 191

  Fly   181 DLMNIQAL-NSDYVKLRNL----------ADYADDYRILWKETDETFHEQRIILDCEPKTLKELL 234
             |..::|: ::.|:..|.|          ...|...|:| ::.|...    ::..|..:..:.|.
  Rat   192 -LEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLL-RQVDAPV----LVAYCSREEAEVLF 250

  Fly   235 KVSIDFKLQGPFRNWFLTHLDTHNS---------GLRDIYNEDFKANITSVRLKVVD-------- 282
            ..:....|.||...|.:.:|...::         ||..:..|.::   .|:|.||.|
  Rat   251 AEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWR---LSLRQKVRDGVAILALG 312

  Fly   283 ANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARN----VIAAMQPFHPPNRHC----- 338
            |:.:.|:                     |..:...|...|:    |..|.:.|:   ||.
  Rat   313 AHSYRRQ---------------------YGTLPAPAGDCRSHPGPVSPAREAFY---RHLLNVTW 353

  Fly   339 -GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDN 402
             |....:..|.::|.....:                          :.:.:..:.|.:..|  |:
  Rat   354 EGRDFSFSPGGYLVRPTMVV--------------------------IALNRHRLWEMVGRW--DH 390

  Fly   403 GIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMM------------------KEDHENF 449
            |:......:....:.:.|...:.|.: ||.|..|.|:.::                  ::.:..|
  Rat   391 GVLYMKYPVWPRYSTSLQPVVDSRHL-TVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTF 454

  Fly   450 RGRE--KY-----EGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQI 506
            ...:  .|     :|:.:|::.||:::::|.|:..:|. |||:....: .|:|:|.::....|.:
  Rat   455 SSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVT-NGKHGKRVRGVWNGMIGEVYYKRADM 518

  Fly   507 GVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMT 569
            .:..|||.:.|..::||:|||::.|||::..:|  ...|.   |||||::..||: |:|...:..
  Rat   519 AIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPS---AFLEPYSPAVWV-MMFVMCLTV 579

  Fly   570 LA-----FVFIARLSYREWL-----PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPR 623
            :|     |.:.:.:||.:.|     |..|:          :.:..|.||:...:......| .||
  Rat   580 VAITVFMFEYFSPVSYNQNLTKGKKPGGPS----------FTIGKSVWLLWALVFNNSVPIENPR 634

  Fly   624 GPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD---LIEQDK---VHFGSMRGG 682
            |...:|:..:|.|||::.|::||||||||:...::..::..|.|   ...||:   ..||::..|
  Rat   635 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNG 699

  Fly   683 STSLFFSESN-DTDYQRAWNQMKDFN----PSAFTSTNKEGVARVRKEKGGYAFLMETTSLTY-- 740
            ||     |.| .::|:.....|..||    ..|.||. |.|...        ||:.:...|.|
  Rat   700 ST-----ERNIRSNYRDMHTHMVKFNQRSVEDALTSL-KMGKLD--------AFIYDAAVLNYMA 750

  Fly   741 NIERNCDLTQI--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCD 803
            ..:..|.|..|  |:......||:|:...|.::..:.:::|||...||.||::..|..  .:..:
  Rat   751 GKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWLS--GICQN 813

  Fly   804 SYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ-----AFKAEL 863
            ..:||...:|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:     ...::|
  Rat   814 EKNEVMSSKLDIDNMAGVFYML----LVAMGLALLVFAW--------EHLVYWKLRHSVPNSSQL 866

  Fly   864 IFALKF 869
            .|.|.|
  Rat   867 DFLLAF 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	74/433 (17%)
		ANF_receptor	46..386	CDD:279440	67/387 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	113/423 (27%)
		Lig_chan	556..828	CDD:278489	80/297 (27%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	75/441 (17%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	113/431 (26%)
		NMDAR2_C	850..>925	CDD:402274	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830