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Protein Alignment GluRIIA and Grin2a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	991	Identity:	215/991 - (21%)
Similarity:	380/991 - (38%)	Gaps:	257/991 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SFDQAFREVNNMKFSE------LRFVTIKRYMPTNDSFLLQQITCELIS----NGVAAIFGPSS- 101
            |.|...||:.|:...|      |....:...|...|...|....|:|:|    :|:  :||..:
  Rat    43 SHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGL--VFGDDTD 105

  Fly   102 -KAASDIVAQIANATGIP----HIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNY 161
             :|.:.::..|::.|.||    |....:.:..........|...::....:|:.:     |..:|
  Rat   106 QEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLK-----IMQDY 165

  Fly   162 EWRTFTLIYETPEGLARL--------------QDLMNIQALNSDY------VKLRNLADYADDYR 206
            :|..|:|:.....|....              .|:.|:..|::.:      |:|:.:
  Rat   166 DWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKI-------- 222

  Fly   207 ILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKA 271
                      |...|:|.|.......:|..:....|.|....|.:..|   .||..::..::|.:
  Rat   223 ----------HSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSL---VSGNTELIPKEFPS 274

  Fly   272 NITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNR 336
            .:.||.....|.:                     |...:.|.:.:..::|.:::...........
  Rat   275 GLISVSYDDWDYS---------------------LEARVRDGLGILTTAASSMLEKFSYIPEAKA 318

  Fly   337 HCGSSSP------WMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPM 395
            .|...:.      ..|..|:||    ::.|.       :::...|.|.::|..|.:
  Rat   319 SCYGQAEKPETPLHTLHQFMVN----VTWDG-------KDLSFTEEGYQVHPRLVV--------- 363

  Fly   396 MVWTPDNGIKKRLLNLELESAG--TTQDFSEQRKVY----------------TVVTHYEEPYFMM 442
            :|...|.         |.|..|  ..|..|.:..|:                ::||..|.| |::
  Rat   364 IVLNKDR---------EWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAP-FVI 418

  Fly   443 KED-------------------------HENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN 482
            .||                         :|....::..:|:.:|::.|||..::|.|:..:|. |
  Rat   419 VEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVT-N 482

  Fly   483 GKYNPETKQ-WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPK 544
            ||:..:... |:|:|.:::...|.:.|..|||.:.|..||||:|||::.|||::..:|  ...|.
  Rat   483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   545 NQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----ARLSYREWLPPNPAIQDPDELENIWNVNNS 605
               ||||||:..||:.|....||::...||:    :.:.|...|....|...|.     :.:..:
  Rat   548 ---AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS-----FTIGKA 604

  Fly   606 TWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLI 669
            .||:.|.:......:. |:|...:|:..:|.|||::.|::||||||||:...::...:..|.|..
  Rat   605 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKK 669

  Fly   670 EQDKVH-------FGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGV--ARVRKE 725
            .| :.|       ||::..|||..  :..|:..|...:          .|..|:.||  |.|..:
  Rat   670 FQ-RPHDYSPPFRFGTVPNGSTER--NIRNNYPYMHQY----------MTRFNQRGVEDALVSLK 721

  Fly   726 KGGY-AFLMETTSLTYNIERN--CDLTQIGEQ--IGEKHYGLAVPLGSDYRTNLSVSILQLSERG 785
            .|.. ||:.:...|.|...|:  |.|..||..  .....||:|:..||.::..:.:::||....|
  Rat   722 TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDG 786

  Fly   786 ELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFE--FLWN--- 843
            |:::::..|...  ||    ..:||...:|.|..:.|||.:||..:.:.:|..|:|  |.|.
  Rat   787 EMEELETLWLTGICHN----EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF 847

  Fly   844 -----------------------VQNVAVEER-------VTPWQAFKAELIFALKFWVRKKPMRI 878
                                   :..|.:||:       :|..|:...:|:.:.|        .|
  Rat   848 CFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAK--------NI 904

  Fly   879 SSSSDKSSSRRSSGSR 894
            |:.|:.:|||..|..|
  Rat   905 SNMSNMNSSRMDSPKR 920

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.