Protein Alignment GluRIIA and Grin1

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001257531.1
• Gene: Grin1 / 24408
• RGDID: 2736
• Length: 959
• Species: Rattus norvegicus
• Alignment Length: 997
• Identity: 215/997 - (21%)
• Similarity: 373/997 - (37%)
• Gaps: 220/997 - (22%)

  Fly    28 DRNEITVGAIFYENEKEIELSFDQAFRE-VN--NMKFSELRF---VTIKRYMPTNDSFLLQQITC 86
            |...:.:||:....:.|      |.||| ||  |.:....:.   .|...:.|......|.  .|
  Rat    23 DPKIVNIGAVLSTRKHE------QMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALS--VC 79

  Fly    87 E-LISNGVAAIF-----GPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS 145
            | |||:.|.||.     .|:.......|:..|....||.:....::.....:.: |...:...|.
  Rat    80 EDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSI-HLSFLRTVPP 143

  Fly   146 LSVLSRAYFEIIKSNYEW-RTFTLIYETPEGLA---RLQDLMNIQALNSDYVKLRNLADYADDYR 206
            .|..|..:||:::. |.| ....|:.:..||.|   ||:.|:..:...|......||...:.|.:
  Rat   144 YSHQSSVWFEMMRV-YNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNK 207

  Fly   207 -------------------ILWKETDETFHEQR-IILDCEPKTLKELLKVSIDFKLQGPFRNWFL 251
                               .|..|..|.  |.| |||.........:.:.:....:.|....|.:
  Rat   208 RGPKAEKVLQFDPGTKNVTALLMEAREL--EARVIILSASEDDAATVYRAAAMLNMTGSGYVWLV 270

  Fly   252 THLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVL 316
            ...:...:.||  |..|....:..:..|...|:                         |.|||.:
  Rat   271 GEREISGNALR--YAPDGIIGLQLINGKNESAH-------------------------ISDAVGV 308

  Fly   317 FASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMK---LDEYGQ 378
            .|.:...::.......||....|:::.|..|                |.||...|.   .|....
  Rat   309 VAQAVHELLEKENITDPPRGCVGNTNIWKTG----------------PLFKRVLMSSKYADGVTG 357

  Fly   379 RIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGT---TQDFSEQRKV------------ 428
            |:.||.:..:...|..:|          .|.|.:|...|.   |......||:
  Rat   358 RVEFNEDGDRKFANYSIM----------NLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRG 412

  Fly   429 ------YTVVTHYEEPYFMMKEDHENFRGREKYE------------------------------- 456
                  ..:||.::||:..:|....:...:|::.
  Rat   413 YQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCY 477

  Fly   457 GYAVDLISKLSELMEFDYEFMIVNGNGKY-------NPETKQWDGIIRKLIDHHAQIGVCDLTIT 514
            |:.:||:.||:..|.|.||..:| .:||:       |...|:|:|::.:|:...|.:.|..|||.
  Rat   478 GFCIDLLIKLARTMNFTYEVHLV-ADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTIN 541

  Fly   515 QMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLS 579
            ..|...::|:.||...|::||..|..|. ....:|::||...:|:.:..:..::.:....:.|.|
  Rat   542 NERAQYIEFSKPFKYQGLTILVKKEIPR-STLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFS 605

  Fly   580 YREWLPPNP----AIQDPDELENIWNVNNSTWLMVGSIMQQGC-DILPRGPHMRILTGMWWFFAL 639
                    |    .:...:|.|:...::::.|...|.::..|. :..||....|||..:|..||:
  Rat   606 --------PFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAM 662

  Fly   640 MMLSTYTANLAAFLTSNKWQSSIKSLQD---LIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWN 701
            :::::|||||||||..::.:..|..:.|   ....||..:.:::..|..::|  ....:....:.
  Rat   663 IIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYF--RRQVELSTMYR 725

  Fly   702 QMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPL 766
            .|:..|    ..:..|.:..||..| .:||:.::..|.:...:.|||...||......:|:.:..
  Rat   726 HMEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRK 785

  Fly   767 GSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLI 831
            .|.::.|:|:|||:..|.|.::.:...|.:...  |||...... .|:...:.|||:::|||::.
  Rat   786 DSPWKQNVSLSILKSHENGFMEDLDKTWVRYQE--CDSRSNAPA-TLTFENMAGVFMLVAGGIVA 847

  Fly   832 GVILGIFEFLWNVQNVAVEERVTPWQAFKAELIF-ALKFW----------------VRKKPMRIS 879
            |:.|...|..:.....|..:::        :|.| |:..|                .:|...|..
  Rat   848 GIFLIFIEIAYKRHKDARRKQM--------QLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAI 904

  Fly   880 SSSDKSSSRRSSGSRRSSKEKS 901
            :|:..||.:|    |||||:.|
  Rat   905 TSTLASSFKR----RRSSKDTS 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	81/410 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	98/433 (23%)
		Lig_chan	555..828	CDD:459656	64/280 (23%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	88/443 (20%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	96/422 (23%)
		CaM_bdg_C0	856..884	CDD:402271	5/35 (14%)