Protein Alignment GluRIIA and Grik4

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_036704.1
• Gene: Grik4 / 24406
• RGDID: 2734
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 809
• Identity: 248/809 - (30%)
• Similarity: 409/809 - (50%)
• Gaps: 74/809 - (9%)

  Fly    86 CELISNGVAAIFGPSSK-AASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVL 149
            |:::..||.|:.||||. |:|.|::.|.....:||  :.:..|...:.||....::|:.||.:.:
  Rat    84 CQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFVRFQLQRFTTLNLHPSNTDI 146

  Fly   150 SRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDE 214
            |.|...|: :.:...|..||....|.|..|:.|:....::.|.:.:|.|.|..|...:|.:..|:
  Rat   147 SVAVAGIL-NFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDD 210

  Fly   215 TFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLK 279
              ....||:.........:|..:.:..:...:..:..|:|:.....:..:.::         |:.
  Rat   211 --KTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDD---------RVN 264

  Fly   280 VVDANPFERKKTRLTKVDQILGNQT--------------MLPILIYDAVVLFASSARNVIAAMQP 330
            ::..:.|.:......:..|.| ||:              :...|::|||..       |:.|:|.
  Rat   265 ILGFSIFNQSHAFFQEFSQSL-NQSWQENCDHVPFTGPALSSALLFDAVYA-------VVTAVQE 321

  Fly   331 FHPPNR---------HCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEI 386
            .   ||         .|||:..|..|..::|.::.:..:.:..|     ::.:..|||.::.|:|
  Rat   322 L---NRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGH-----IEFNSKGQRSNYALKI 378

  Fly   387 YKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQDFSEQ--RKVYTVVTHYEEPYFMMKEDHE 447
            .:.|.|....:  |....|       |.::|.....:.|:.  .....|.|..|.||.|:|.:|:
  Rat   379 LQFTRNGFRQIGQWHVAEG-------LSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQ 436

  Fly   448 NFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYN-PETK-QWDGIIRKLIDHHAQIGVCD 510
            :..|.::|||:.||::.:|:|::.|:|:..:| |:|.|. ||.. .|.|::.:||...|.:.|..
  Rat   437 DMEGNDRYEGFCVDMLKELAEILRFNYKIRLV-GDGVYGVPEANGTWTGMVGELIARKADLAVAG 500

  Fly   511 LTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI 575
            ||||..|..|:||:.|||.||||||:..........|:||:||:..||::|:.|.|.::.....:
  Rat   501 LTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565

  Fly   576 ARLSYREWLPPNPAIQDP-DELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFAL 639
            |||:..||..|:|..|.. :.|.|.:::.||.|..||..||||..|.||....|.::|:||.|.|
  Rat   566 ARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTL 630

  Fly   640 MMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMK 704
            :::|:||||||||||..:.:..|:|:.||.:|..:.:|::.|||:..||..|....|||.||.|.
  Rat   631 IIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMY 695

  Fly   705 DFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSD 769
            ...||.|..:.:||:|||.  ...||||:|:|...|..:|||:|||||..:..|.||:.:|:||.
  Rat   696 SKQPSVFVKSTEEGIARVL--NSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSV 758

  Fly   770 YRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVI 834
            :|....::||||.|...|:.:|.|||:......:..|...|  |.:..:||:|:||..|:::.:.
  Rat   759 FRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKG--LGMENIGGIFVVLICGLIVAIF 821

  Fly   835 LGIFEFLWNVQNVAVEERVTPWQAFKAEL 863
            :.:.||||.:::....| |:..|....||
  Rat   822 MAMLEFLWTLRHSEASE-VSVCQEMMTEL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	73/344 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	153/372 (41%)
		Lig_chan	555..828	CDD:459656	110/273 (40%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	74/354 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	153/372 (41%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956