Protein Alignment GluRIIA and Grin3a

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 985
• Identity: 211/985 - (21%)
• Similarity: 375/985 - (38%)
• Gaps: 223/985 - (22%)

  Fly    35 GAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP----TNDSFLLQQITCE-LISNGVA 94
            |.:.|....|:.::.:....::..|.||.          |    ::|.|...|..|. ::..||:
Mouse   140 GLLPYNLSLEVVMAIEAGLGDLPLMPFSS----------PSSPWSSDPFSFLQSVCHTVVVQGVS 194

  Fly    95 AIFG-PSSKAAS---DIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSI--------NVAPSLS 147
            |:.. |.|:...   |:|:.:.:...:..:.::...|:  |..|:.|:|:        :|..|:.
Mouse   195 ALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRES--QNPLHLQLSLENSLSSDADVTVSIL 257

  Fly   148 VLSRAY-FEIIKSNYEWR--TFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILW 209
            .::..| |.::....:|.  .|.|:.|. .....|:.::||.|         ||:...|....|.
Mouse   258 TMNNWYNFSLLLCQEDWNITDFLLLTEN-NSKFHLESIINITA---------NLSSTKDLLSFLQ 312

  Fly   210 KETDETFHE--QRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKAN 272
            .:.:...:.  ..::..|:..:::::.::|..|.|..|..:|.|..                ..|
Mouse   313 VQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGD----------------SQN 361

  Fly   273 ITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAA--MQP---FH 332
            :..:|.:.:........||          .|::....:.||:.|.   ||.|..|  :||   ..
Mouse   362 VEELRTEGLPLGLIAHGKT----------TQSVFEYYVQDAMELV---ARAVATATMIQPELALL 413

  Fly   333 PPNRHC------GSSSPWMLGAFIVN----------EMKTISEDDVEPHFKTENMKLDEYGQRIH 381
            |...:|      ..:|...|..|:.|          ::|..:....|.:|...|::.|..|
Mouse   414 PSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMG---- 474

  Fly   382 FNLEIYKPTVNEPMMVWT-----------PDNGIKKRLLNLELESAGTTQDFSEQRKVY-TVVTH 434
                  ||       :||           .|:||...      ::......|....|:: .|||.
Mouse   475 ------KP-------MWTRLGSWQGGRIVMDSGIWPE------QAQRHKTHFHHPNKLHLRVVTL 520

  Fly   435 YEEPYFMMKE-DHEN----------------------------------FRGREKYEGYAVDLIS 464
            .|.|:...:| |.|.                                  .:.::...||.:||:.
Mouse   521 IEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLE 585

  Fly   465 KLSELMEFDYEFMIVNGNGKYNP-ETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFM 528
            :|:|.|.||::..|| |:|||.. :...|.|::..|:...|.:.|...:|...|..|:|||.||.
Mouse   586 QLAEDMNFDFDLYIV-GDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFF 649

  Fly   529 QLGISIL-HYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQD 592
            ...:.|| ..:....|..  ||:.|....:|: .||..|.:|..|     |:..||..|......
Mouse   650 STSLGILVRTRDTAAPIG--AFMWPLHWTMWL-GIFVALHITAIF-----LTLYEWKSPFGMTPK 706

  Fly   593 PDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHM---RILTGMWWFFALMMLSTYTANLAAFLT 654
            ......:::.:::..:....:..:...|.|  |..   |.|..:|..|.:..||||||||||.:.
Mouse   707 GRNRNKVFSFSSALNVCYALLFGRTAAIKP--PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMV 769

  Fly   655 SNKWQSSIKSLQDLIEQDKVH-------FGSMRGGSTSLFFSESNDTDYQR-AWNQMKDFNPSAF 711
            ..|....:..:.|    .|:|       ||::|         ||:..||.| ::.:|.::.....
Mouse   770 GEKIYEELSGIHD----PKLHHPSQGFRFGTVR---------ESSAEDYVRQSFPEMHEYMRRYN 821

  Fly   712 TSTNKEGVARVRKEKGGY-AFLMETTSLTY--NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTN 773
            .....:||..::.:.... ||:|:...|.|  :|:.:|.|..:|:....:.||:.:|..|...:|
Mouse   822 VPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSN 886

  Fly   774 LSVSILQLSERGELQKMKNKWWKNHNVTCD--SYHEVDGDELSIIELGGVFLVLAGGVLIGVILG 836
            :|..|.|....|.:..:.:||:|  .|.|.  |:...:..::.|....|:|::|..|..:.::..
Mouse   887 ISELISQYKSHGFMDVLHDKWYK--VVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTT 949

  Fly   837 IFE------FLWNVQNVAVEERVTPW----QAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSS 891
            |.|      .|..::|   :.::..|    |.|...|  ...|...|:|...:...:||..||.:
Mouse   950 IGEHIVYRLLLPRIKN---KSKLQYWLHTSQRFHRAL--NTSFVEEKQPCSKTKRVEKSRWRRWT 1009

  Fly   892 GSRRSSKEKS 901
            .......|.|
Mouse  1010 CKTEGDSELS 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	78/423 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	105/421 (25%)
		Lig_chan	555..828	CDD:459656	70/288 (24%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	78/423 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	104/419 (25%)
		Lig_chan	674..941	CDD:459656	70/289 (24%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		7/40 (18%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115