DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Grin3a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	982	Identity:	210/982 - (21%)
Similarity:	375/982 - (38%)	Gaps:	217/982 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP----TNDSFLLQQITCE-LISNGVA 94
            |.:.|....|:.::.:....::..|.||.          |    ::|.|...|..|. ::..||:
  Rat   140 GLLPYNLSLEVVMAIEAGLGDLPLMPFSS----------PSSPWSSDPFSFLQSVCHTVVVQGVS 194

  Fly    95 AIFG-PSSKAAS---DIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSI--------NVAPSLS 147
            |:.. |.|:...   |:|:.:.:...:..:.::...|:  |..|:.|:|:        :|..|:.
  Rat   195 ALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRES--QNPLHLQLSLENSLSSDADVTVSIL 257

  Fly   148 VLSRAY-FEIIKSNYEWR--TFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILW 209
            .::..| |.::....:|.  .|.|:.|. .....|:.::||.|         ||:...|....|.
  Rat   258 TMNNWYNFSLLLCQEDWNITDFLLLTEN-NSKFHLESVINITA---------NLSSTKDLLSFLQ 312

  Fly   210 KETDETFHE--QRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKAN 272
            .:.|...:.  ..::..|:..:::::.::|..|.|..|..:|.|..                ..|
  Rat   313 VQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGD----------------SQN 361

  Fly   273 ITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAA--MQP---FH 332
            :..:|.:.:........||          .|::....:.||:.|.   ||.|..|  :||   ..
  Rat   362 VEELRTEGLPLGLIAHGKT----------TQSVFEYYVQDAMELV---ARAVATATMIQPELALL 413

  Fly   333 PPNRHC------GSSSPWMLGAFIVN----------EMKTISEDDVEPHFKTENMKLDEYGQRIH 381
            |...:|      ..:|...|..|:.|          ::|..:....|.:|...|::.|..|
  Rat   414 PSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMG---- 474

  Fly   382 FNLEIYKPTVNEPMMVWT-----------PDNGIKKRLLNLELESAGTTQDFSEQRKVY-TVVTH 434
                  ||       :||           .|:||...      ::......|....|:: .|||.
  Rat   475 ------KP-------MWTRLGSWQGGRIVMDSGIWPE------QAQRHKTHFQHPNKLHLRVVTL 520

  Fly   435 YEEPYFMMKE-DHEN----------------------------------FRGREKYEGYAVDLIS 464
            .|.|:...:| |.|.                                  .:.::...||.:||:.
  Rat   521 IEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLE 585

  Fly   465 KLSELMEFDYEFMIVNGNGKYNP-ETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFM 528
            :|:|.|.||::..|| |:|||.. :...|.|::..|:...|.:.|...:|...|..|:|||.||.
  Rat   586 QLAEDMNFDFDLYIV-GDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFF 649

  Fly   529 QLGISIL-HYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQD 592
            ...:.|| ..:....|..  ||:.|....:|: .||..|.:|..|     |:..||..|......
  Rat   650 STSLGILVRTRDTAAPIG--AFMWPLHWTMWL-GIFVALHITAIF-----LTLYEWKSPFGMTPK 706

  Fly   593 PDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHM---RILTGMWWFFALMMLSTYTANLAAFLT 654
            ......:::.:::..:....:..:...|.|  |..   |.|..:|..|.:..||||||||||.:.
  Rat   707 GRNRNKVFSFSSALNVCYALLFGRTAAIKP--PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMV 769

  Fly   655 SNKWQSSIKSLQDLIEQDKVH-------FGSMRGGSTSLFFSESNDTDYQR-AWNQMKDFNPSAF 711
            ..|....:..:.|    .|:|       ||::|         ||:..||.| ::.:|.::.....
  Rat   770 GEKIYEELSGIHD----PKLHHPSQGFRFGTVR---------ESSAEDYVRQSFPEMHEYMRRYN 821

  Fly   712 TSTNKEGVARVRKEKGGY-AFLMETTSLTY--NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTN 773
            .....:||..::.:.... ||:|:...|.|  :|:.:|.|..:|:....:.||:.:|..|...:|
  Rat   822 VPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSN 886

  Fly   774 LSVSILQLSERGELQKMKNKWWKNHNVTCD--SYHEVDGDELSIIELGGVFLVLAGGVLIGVILG 836
            :|..|.|....|.:..:.:||:|  .|.|.  |:...:..::.|....|:|::|..|..:.::..
  Rat   887 ISELISQYKSHGFMDVLHDKWYK--VVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTT 949

  Fly   837 IFEFLWN---VQNVAVEERVTPW----QAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSR 894
            |.|.:.:   :..:..:.::..|    |.|...|  ...|...|:|...:...:||..||.:...
  Rat   950 IGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRAL--NTSFVEEKQPRSKTKRVEKSRWRRWTCKT 1012

  Fly   895 RSSKEKS 901
            ....|.|
  Rat  1013 EGDSELS 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	78/422 (18%)
		ANF_receptor	46..386	CDD:279440	70/382 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	105/421 (25%)
		Lig_chan	556..828	CDD:278489	70/287 (24%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	80/424 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	71/379 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	104/419 (25%)
		Lig_chan	676..942	CDD:278489	70/288 (24%)
		PPP2CB binding site	951..987		5/37 (14%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830