DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and T25E4.2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001364710.1	Gene:	T25E4.2 / 188897	WormBaseID:	WBGene00020804	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	318	Identity:	63/318 - (19%)
Similarity:	115/318 - (36%)	Gaps:	81/318 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 SELMEFDYEFMIVNGNGKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSV-----VDFTVP 526
            :|:...:..|.::|...    ...|.|..|.:.||..:. |..|:|:...|:::     ||||.|
Worm    36 AEVEFLNMTFQLMNSTA----TIVQIDADIEQSIDMVSN-GSADITLVSARQTLDRMKKVDFTTP 95

  Fly   527 FMQLGISILHY----KSPPEPKNQFAFLEPF-----AVEVWIYMIFAQLIMTLAFVFIARL-SYR 581
                 |..::|    :..||.......:..|     |:.:...:|...|:....::|..|: |..
Worm    96 -----IGFVYYGYLVREIPELAVADYIMRLFDYDTLAILISFGLIIGALLYLYTWIFGLRVRSLL 155

  Fly   582 EWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYT 646
            :|:                      ::....|:.|....:.......:|.|.|....|::::.|.
Worm   156 DWM----------------------FISCSGIIHQFMFRISSPICALVLIGFWLLCCLVIITYYE 198

  Fly   647 ANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAF 711
            |.|.:||..:..:.:|.:..|.:.:...|.|      .:|...|...|.|...       |||.
Worm   199 AKLKSFLLLSHHRGTIFNTLDGVLEAAEHKG------WTLVIQERGYTPYLYC-------NPSQ- 249

  Fly   712 TSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSD 769
                   .||:.:.|....|:        ..:.:.:|. :|:   :||.|.:. |.||
Worm   250 -------CARLDRLKSRINFI--------GADDDANLL-LGQ---DKHVGFSA-LASD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377
		ANF_receptor	46..386	CDD:279440
		PBP2_iGluR_Kainate	426..796	CDD:270432	63/318 (20%)
		Lig_chan	556..828	CDD:278489	40/215 (19%)
T25E4.2	NP_001364710.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900