Protein Alignment GluRIIA and glr-8

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001368711.1
• Gene: glr-8 / 180924
• WormBaseID: WBGene00001619
• Length: 547
• Species: Caenorhabditis elegans
• Alignment Length: 527
• Identity: 125/527 - (23%)
• Similarity: 208/527 - (39%)
• Gaps: 103/527 - (19%)

  Fly   364 PHFKTENMKLDEYGQRIHFNL--EIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFS--- 423
            |.|  ||...|....|...|:  .|.:...:.|....|.|.|....|.|        .:.||
 Worm     4 PEF--ENTTADPNSIRTLNNILESINEKVAHPPQTSLTSDYGDAYTLSN--------EKHFSLSE 58

  Fly   424 -EQRKVYTVVTHYEEPYFMMKEDHENFRGREKYE-----GYAVDLISKLSELMEFDYEFMIVNGN 482
             :.|.:..||...|.||.    ::.||......:     |..::::.::.:.:...||.:...|:
 Worm    59 MKGRTLKMVVPAIEPPYV----NYVNFSDAAVTDKGYGPGVVMEILKEIGKRLNLTYEILPALGS 119

  Fly   483 --GKYNPETKQWDGIIRKLIDHHAQIGVCDL----TITQMRRSVV-DFTVPFM--QLGISILHYK 538
              |:|  ....|.|...:|:.     |..||    .|.:..|||: |.|.||.  ..||.|   :
 Worm   120 TWGEY--LNGSWTGAFGQLVR-----GEVDLLAGGAIMEYDRSVIADLTYPFQFEPTGIMI---R 174

  Fly   539 SPPEPKNQFAFL--EPFAVEVWIYMIFAQLIMTLAFVF-----IARLSYREWLPPNPAIQDPDEL 596
            ||.:.::....:  |||:.|||:  |.|.:|:....:|     |.|..|.| :...|.
 Worm   175 SPEKYEDDTLLIVTEPFSWEVWV--ITAAVILISGVIFLVMTNIIRKVYEE-MTVTPF------- 229

  Fly   597 ENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSS 661
                   .|.|:.....:|||....||....|:|..:||..::.:.:|:|.:|.|....:|....
 Worm   230 -------ESIWVFFSIFVQQGLPEQPRSWSCRVLVALWWLASITLSATFTGSLVALFAVDKTNVP 287

  Fly   662 IKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTD-----------YQRAWNQMKDFNPSAFTSTN 715
            .:::..|:.       .::.|...:...|::.|.           |:..|::|...:...:.:..
 Worm   288 FQNIDQLVR-------LVKQGKFEIVMDENSFTRTEMIARSKLPVYRDLWHEMIVNHKVKYVNGI 345

  Fly   716 KEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPL--GSDYRTNLSVSI 778
            ..|||.||... |||.|....:|.:....:|.:....:.|...:  |::||  .|.|....|..|
 Worm   346 ARGVAFVRANP-GYALLGPMATLNFYAYSDCKVILFNDGILPVY--LSIPLVKNSIYSPYFSTKI 407

  Fly   779 LQLSERGELQKMKNKWWKNHN--VTCDSYHEVDGDEL---SIIEL---GGVFLVLAGGVLIGVIL 835
            .::.|||..|    ||..::.  |.....:|.:...:   |.::|   .|.|.|..||..:|:.|
 Worm   408 REMVERGFTQ----KWIADYRSYVAMQKINECNSTTIGPKSYLDLKRAQGAFWVFLGGAGLGLAL 468

  Fly   836 GIFEFLW 842
            .:.||::
 Worm   469 FVGEFIF 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	12/42 (29%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	96/403 (24%)
		Lig_chan	555..828	CDD:459656	67/298 (22%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	96/406 (24%)