Protein Alignment GluRIIA and glr-7

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001337310.1
• Gene: glr-7 / 180547
• WormBaseID: WBGene00001618
• Length: 885
• Species: Caenorhabditis elegans
• Alignment Length: 868
• Identity: 202/868 - (23%)
• Similarity: 357/868 - (41%)
• Gaps: 157/868 - (18%)

  Fly    67 VTIKRYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQ 131
            ::::|| ..|||..:..: |:.:.|....|....|..:..:||::|..:.:|.|:.||...:.
 Worm    12 ISLERY-DFNDSSDINSL-CDQMVNVSFVISVCRSNDSISLVAELARISQVPTIQVDLNYWSL-- 72

  Fly   132 EQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYE------------TPEGLARLQDLMN 184
                 .::.|.....::.|.:|..::.|       ||:::            ||.... |.|.|
 Worm    73 -----PLNFNGTSVPTISSPSYTTMVLS-------TLVFQNVITDIFADLNITPNSTV-LYDNM- 123

  Fly   185 IQALNSDYVKLRNLADYADDYRILWKETDETFHEQR-------------IILDCEPKTLKELLKV 236
               ...|:...|:........|.:..||  |....|             :||..:.:.::.....
 Worm   124 ---YPPDFTAWRDAFSVLPGIRFVPMET--TVLRMRAQITQLRMASINSLILVAKTENVERFTLE 183

  Fly   237 SIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANI-------------TSVRLKVVDANPFER 288
            :.||..|..|..:.||         :||  ..||.:.             ....:::.|.:.:..
 Worm   184 AADFIEQRVFNTYVLT---------KDI--TAFKCDSCESAFMFWLRPFPVGKLMEIRDLDDYLF 237

  Fly   289 KKTRLTKVDQILGNQTMLPILIYDAVVLFA-SSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFI 350
            :.....::|..:.....|.:..|..|:.:| .:.|.:.|.....  |...|  |.|.|
 Worm   238 RNEIGLELDYSINGWDSLNVAFYMNVMGYAFETIRTMNATFDVL--PTFTCQTGPSEP------- 293

  Fly   351 VNEMKTISEDDV--EPHFKTENMKLDEYGQRIHF---NLEIYK---------PTVNEPMMVWTPD 401
              .:.|...|.:  :|..:..|  ..|.|..:.|   .:.|||         ...|:.:.||:|.
 Worm   294 --NITTTVRDIILNDPAHEYGN--YTEAGLNMFFQDVEVRIYKIDRDRDHEDALFNKEVGVWSPI 354

  Fly   402 NGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKL 466
            :.:....        ||.|.......::.|||..:.|:.....|.:.     .||||.:|||:.:
 Worm   355 SKLSVMY--------GTLQVDVRNLNIFRVVTLIQPPFVQRTGDPDT-----PYEGYCIDLINMI 406

  Fly   467 SELMEFDYE-FMIVNGNGKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQL 530
            ...:.|.|. :.:.:|:.....:...|:|:|..|:...|.|.:..|::...|.:.||||||:..|
 Worm   407 QVEVNFTYTIYEVEDGSFGTMDDNGNWNGLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDL 471

  Fly   531 -GISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPD 594
             |.:||..|:..| .:.|.|::.....||:.::.|.|..::......|.|...:.......|:..
 Worm   472 VGTTILMKKADVE-YSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTNNKERYQNDI 535

  Fly   595 ELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQ 659
            | :..:::....|..:.|:..||....|:....|::...||.|..:::::||||||||||.::.:
 Worm   536 E-KRQFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSRLE 599

  Fly   660 SSIKSLQDLIEQDKVHFGSMRGGSTSLFF---SESNDTDYQRAWNQM---KDFNP---------- 708
            ..|.||.||.:|.|:.:..::|.::..:|   :|..:|.| ..|.:|   :..:|
 Worm   600 QPISSLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFY-NMWKEMSLNESMSPRDRAKLAVWD 663

  Fly   709 ----SAFTS-----------TNKE-GVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGE 757
                ..||:           .|.: .|.||.....|:||:.:.|.:.|....||:|.|:|.:...
 Worm   664 YPVSDKFTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCNLQQVGTEFSR 728

  Fly   758 KHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTC-DSYHEVDGDELSIIELG 819
            |.|.:||..|...:..:|.:||.|.....|:.:|.|||.:  :.|:| ||..|.||  :||..:|
 Worm   729 KPYAIAVQSGHILKDKISSAILMLLNERRLETLKEKWWTDNPNKVSCPDSSDESDG--ISIQNIG 791

  Fly   820 GVFLVLAGGVLIGVILGIFEFLW 842
            |||:|:..|:.:.::...||:.:
 Worm   792 GVFIVILAGIALSIVTLAFEYYY 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	73/391 (19%)
		ANF_receptor	46..386	CDD:279440	66/364 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	108/403 (27%)
		Lig_chan	556..828	CDD:278489	86/306 (28%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	24/135 (18%)
		PBP2_iGluR_putative	373..767	CDD:270435	108/401 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810