Protein Alignment GluRIIA and nmr-2

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001256640.1
• Gene: nmr-2 / 180002
• WormBaseID: WBGene00003775
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 1055
• Identity: 233/1055 - (22%)
• Similarity: 403/1055 - (38%)
• Gaps: 257/1055 - (24%)

  Fly     9 YAFIIIIGFLE--GIIALGG---------DDRNEITVGAIFYENEKEIELSFDQAFREV-----N 57
            :..:::..|.|  ..|.|||         |.:.|....|:.|::......|:|:||:||     :
 Worm     7 FILLLLATFFEKNQSIDLGGSRKVQKPKEDPKREDVNIAVVYQHYAGRSKSYDKAFKEVIRKIND 71

  Fly    58 NMKFSELR-------FVTIKRYMPTNDSFLLQQITC---ELISNGVAAIF-------GPSSKAAS 105
            ....|.||       |..:...:||...|:.:.:.|   .:.||.||.|.       ..|:.||.
 Worm    72 ATAVSSLRRLATRYNFQAVDCILPTGTFFVKEVLDCLCNNVTSNNVALIIFVTASETYDSTTAAE 136

  Fly   106 DIVAQIANATGIPHIEYDL-KLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLI 169
            ......|:.||||.|.::. ....|.:..|.....|.:||.:...:||...::: .|.|..|.::
 Worm   137 QYFLTAASYTGIPIIAWNADNAGFTFENDLGPYRIIQMAPPIEHQARAMLALLR-RYNWPKFGVV 200

  Fly   170 YETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELL 234
            .....|             |..:|                     |...:.:.|.....|..|::
 Worm   201 TSEMAG-------------NDRFV---------------------TAIREELELFSNKSTKFEMI 231

  Fly   235 KVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQI 299
            ..|               |::|.|....|:...|.|.|...:.|...:|.......:...|:|.|
 Worm   232 HFS---------------HMNTKNDTDVDLKLADVKKNQAKIILLYANAAQAGTIFSHAEKMDMI 281

  Fly   300 ------------LGNQT----------------------------MLPILIYDAVVLFASSARNV 324
                        .|.||                            :||::|..|..||.
 Worm   282 GEKYLWIGTQSVKGTQTTVKAPAQAGMLCVNFHTVSNAMFAPRDDILPLIIQLAPKLFG------ 340

  Fly   325 IAAMQPFHP-------PNRHCGSSSP---WMLGAFIVNEMKT-------ISEDDVEPHF-----K 367
             ||:....|       .|..|.|...   |..|.:|...||.       ...||....|     |
 Worm   341 -AALLQLRPNEMFSLKSNVSCKSEDGDPYWDNGKYIYEHMKAAFVKGNPFHVDDGHDSFFYTFEK 404

  Fly   368 T----------ENMKLDEYGQRIHFNLEIYKPTVNEPMMV---WTPDNGIKKRLLNLELESAGTT 419
            |          .|::.:..|::....:.|:  |.||..|.   |..             |.|...
 Worm   405 TGRLRNSILQISNLRTNSKGEKTWEKVGIF--TNNELKMADVQWPG-------------EKANPP 454

  Fly   420 QDFSEQRKVYTVVTHYEEPYFMMKE---DHENFRGRE---------KY----------------E 456
            |..:::..| .|||.:|.|:..:.:   |.:...|.:         :|                .
 Worm   455 QGAADKFHV-KVVTLHEPPFIAVSDVDPDTQKCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCS 518

  Fly   457 GYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQ-WDGIIRKLIDHHAQIGVCDLTITQMRRSV 520
            ||.|||::||:..:.|.|....|. :.|:..:|:. |:|:|..|:.:.|.:.|..|.:...|...
 Worm   519 GYCVDLLNKLANDIGFTYTLYKVR-DEKWGLKTENGWNGLIADLMHNKADMCVTSLKLNSERARD 582

  Fly   521 VDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLP 585
            :||::||:..||||: .|......:..||||||....|:.::|..:.:....:|:.     ||:.
 Worm   583 IDFSLPFLDTGISII-VKIRSGVLSPTAFLEPFEYSTWVIILFVCIHVAAISIFLF-----EWVS 641

  Fly   586 P---NPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPRGPHMRILTGMWWFFALMMLSTYT 646
            |   |.....|.  |:.:::..|.||:..::....... :|:....|::..:|..|.|..|:.||
 Worm   642 PYSFNMQKYPPP--EHKFSLFRSYWLVWATLFSASVSTDVPKSTVSRLMALVWAAFGLTFLAVYT 704

  Fly   647 ANLAAFLTSNKWQSSIKSLQDLI------EQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKD 705
            ||||||:.:......:..:.|.:      ::....||::.||:|       ::| .:|.|::|.:
 Worm   705 ANLAAFMITRVQYYDLSGIHDPMLNFPHDQKPPFRFGTVDGGNT-------HET-MKRNWHKMHE 761

  Fly   706 F--NPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTY--NIERNCDLTQIGEQIGEKHYGLAVPL 766
            :  :...|......|:..|:.|:.. ||:.:...|.|  ..:.||.|..:|:......||:..|.
 Worm   762 YVKHNKYFRMNISAGIEAVKNEELD-AFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPK 825

  Fly   767 GSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLI 831
            .|.:.:.::..:||..::|:|::::| :|.....|.||:.:.....|.|......|::||||:::
 Worm   826 NSPHTSLVNHYMLQYQQKGDLERLQN-FWLTGACTPDSHSQTQSAPLGIENFLSAFVLLAGGIIV 889

  Fly   832 GVILGIFEFLWNVQNVAVEERVTP--W-----QAFKAELIFA-----LKFWVRKKPMRISSSSDK 884
            .||:..||.::.:......:::.|  |     .|....|.|.     ::.| |.:...::|::..
 Worm   890 SVIVLGFEHIYCMHLRKPLQKIDPNGWCGIISMAMGKSLTFTEAVDRVQEW-RSRTQSLASTNSP 953

  Fly   885 SSSRRSSGSRRSSKE 899
            ...||.|.:.|.::|
 Worm   954 QLKRRRSANLRPTEE 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	93/469 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	101/412 (25%)
		Lig_chan	555..828	CDD:459656	66/286 (23%)
nmr-2	NP_001256640.1	Periplasmic_Binding_Protein_type1	102..443	CDD:471960	77/399 (19%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:473866	102/419 (24%)