DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and glr-5

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	939	Identity:	256/939 - (27%)
Similarity:	440/939 - (46%)	Gaps:	129/939 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VGAIFYENEKEIELSFDQAFREVNNMKFSELRFV-----TIKRYMPTNDSFLLQQITCELI-SNG 92
            :||||.|.|   :...:.|.|  .::::...|.:     .:..|:...|.:...:..|::: .:.
Worm    27 IGAIFRERE---DAHIEAAVR--YSVEWLSQRGIYGDIDLVIEYIDVLDHYDAIKKACKMLEKDH 86

  Fly    93 VAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEII 157
            :.|:.|.|..|.:..:.:|.:...||.:   ..::..|.:....::.....|.|       ||.:
Worm    87 IVALLGGSHAALNAQLERITDDLDIPFL---TAIDDLRTDMGKSKIDFWPRPQL-------FEAV 141

  Fly   158 K---SNYEWRTFTLIYETPEGLARLQDLMN-----------IQALNSDYVKLRNLADYADDYRIL 208
            .   :::.|....|:||..|.:.||:.|:.           |:..:.||:|........::.|:|
Worm   142 VDMFTHWRWNRIVLVYEGDERIRRLEQLLESEEYASIRFYLIKVHDGDYMKAARQVKELEECRLL 206

  Fly   209 WKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKAN- 272
            .|:....|  .|:::|..|:.....|..|:...|. ..::|||    ..|..|..:..|.|:.|
Worm   207 HKKDCSEF--SRLLVDMNPEHTYTFLLASLQMGLI-ELKHWFL----LTNMELSTMDMELFRYNH 264

  Fly   273 -------------ITSVRLKVVDANPFERKKTRLT-----KVDQILGNQTMLPILIYDAVVLFAS 319
                         :|..|    ||..|...|..:|     |.|.....:.|..:..:|||..||:
Worm   265 ARFISPYPVDSTFLTENR----DAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFDAVYAFAN 325

  Fly   320 SARNVIAAMQPFHPPNRHCGSSS----PWMLGAFIV-----NEMKTISEDDVEPHFKTENMKLDE 375
            ....:.:.||....|...|..||    .:..|..::     |::..:|.|         ..:|:.
Worm   326 VFNELSSHMQMNDVPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGD---------LRRLNG 381

  Fly   376 YGQRIHFNLEI----YKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQ---DFSEQRKV-YTVV 432
            :..:.:|::.|    |...::: :..|.|...:.   :|:..:|....|   ..|::.|. :.|.
Worm   382 HPLKSNFSMRIQLLGYSGRLDD-IGFWEPATNVH---VNMSGDSKAQLQRNVQVSDELKPHFRVT 442

  Fly   433 THYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVN----GNGKYNPETKQWD 493
            |..|.||.|:|::|.......|:||:.:||:::||:.:.|.|....|.    ||.||.  ...||
Worm   443 TIMERPYVMLKKNHYELDANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGNDKYG--NGSWD 505

  Fly   494 GIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPK-NQFAFLEPFAVEV 557
            |::.:::...|::.|..||:...|...||||.||:.|||||| ||.|.:.: :.|:||.|.:.::
Worm   506 GMMGEILRGEAEMAVAPLTVNYRRSEAVDFTKPFLSLGISIL-YKVPDDQQPDLFSFLNPLSWQI 569

  Fly   558 WIYMIFAQLIMTLAFVFIARLSYREW---------LPPNPAI------QDPDELENIWNVNNSTW 607
            |..:..:.:.:||...|:|.::..||         ..|:||.      :.|..:.|.::..|:.|
Worm   570 WTAIATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMSNNYSFWNTVW 634

  Fly   608 LMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQD 672
            .::.::::.|||..||....|:|.|.||.|.|:::|.|||||||.||.::....||:|.||..|.
Worm   635 YVLSTMLKGGCDFGPRAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLANQT 699

  Fly   673 KVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTS 737
            .:.:|::|||||..||.||....:.:.|..|||  ...|.::|.:||.|....  .||:|||:||
Worm   700 TISYGTIRGGSTMQFFQESRIAAHVKMWQYMKD--KDVFVTSNGKGVERALSM--NYAYLMESTS 760

  Fly   738 LTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTC 802
            |.|..::||:|||||..:|.|.||:|:...|::...:|..||..::||.::..|.|||::....|
Worm   761 LEYETQQNCNLTQIGGVLGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKWWRSKGAAC 825

  Fly   803 DSYHEV---DGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELI 864
            .|....   |...||:..:.|:|:.|..|:::..|:.|||.:....::|.:|    .:.|..||:
Worm   826 ASTASAVKHDRFALSMYNVAGLFITLGVGIVLAAIVVIFELIHRCHHIAKKE----GKPFLEELL 886

  Fly   865 FALKFWVRKKPMRISSSSDKSSSRRSSGS 893
            :.|:|.:....:....|..|.|:..|:|:
Worm   887 YELRFALNMNSLSDHRSRQKMSTCNSNGN 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	85/421 (20%)
		ANF_receptor	46..386	CDD:279440	75/387 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	141/390 (36%)
		Lig_chan	556..828	CDD:278489	100/289 (35%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	86/429 (20%)
		ANF_receptor	38..377	CDD:279440	73/370 (20%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	140/387 (36%)
		Lig_chan	568..855	CDD:278489	100/290 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780