Protein Alignment GluRIIA and glr-1

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_498887.2
• Gene: glr-1 / 176204
• WormBaseID: WBGene00001612
• Length: 962
• Species: Caenorhabditis elegans
• Alignment Length: 924
• Identity: 252/924 - (27%)
• Similarity: 425/924 - (45%)
• Gaps: 148/924 - (16%)

  Fly    78 SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYD-LKLEATRQEQLNHQMSIN 141
            |:.:....|:.:..|..|:.........:.:..:::|..:|.:... |..:..:|:|..:...::
 Worm    80 SWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVS 144

  Fly   142 VAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDL-MNIQALNSDYVKL---------R 196
            |.|.:|.| .|.|.:.|.   |....::.:.......|..| .:::...:..||.         :
 Worm   145 VRPPISEL-LADFIVHKG---WGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEK 205

  Fly   197 NLADYADDYRILWKETDETFHEQRIILDC-EPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSG 260
            ....|...:.::  ..:||   .||::|| .||.||:|| ::|        |:......:.|..
 Worm   206 QFEAYLMQFNMM--RNNET---NRILIDCASPKRLKKLL-INI--------RSAQFNQANYHYV- 255

  Fly   261 LRDIYNEDF-----------KANITSVRLKVVDANPFERKKTRL-----------TKVDQILGNQ 303
               :.|.||           ..||:...:...|...:...|..|           ..|:..:|:.
 Worm   256 ---LANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHD 317

  Fly   304 TMLPILIYDAVVLFASSARNVIAAMQPFHPPNRH------------CGSSS-------PW----- 344
            .||        |.:...|:.:.|....||...||            |...|       |:
 Worm   318 AML--------VTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPFSSFEH 374

  Fly   345 --MLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIY------KPTVN-EPMMVWTP 400
              .:|....| ||...::..    .|.|::.|.:|.|.:|::.|.      |.|.| :.::.|..
 Worm   375 GKTIGVAFRN-MKIGHKEGT----LTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQ 434

  Fly   401 DNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKED------HENFRGREKYEGYA 459
            ..|.... ..:...|..:..|..:.:.:  |:|:...|:.|:|.:      ....:|..|:||:.
 Worm   435 GVGFFSN-RTVAQHSRKSQNDHKDNQVI--VLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFC 496

  Fly   460 VDLISKLSE-LMEFDYEFMIVNGNGKYNPETKQ----WDGIIRKLIDHHAQIGVCDLTITQMRRS 519
            :||:..|:: :.||:||..:....|     :||    |||:|.:|:...|...|..|||.|.|..
 Worm   497 IDLLKLLADKIEEFNYEIKLGTKAG-----SKQADGSWDGMIGELLSGRAHAVVASLTINQERER 556

  Fly   520 VVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWL 584
            ||||:.|||..||||:..|...:..:.|:|::|.:.|:|:|:|||.:.:::....::|.|..||
 Worm   557 VVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEW- 620

  Fly   585 PPNPAIQDPDE----LENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTY 645
                .:::...    :.|.::|.|..|..:.:.||||.|||||....||.:..||||.::::|:|
 Worm   621 ----RVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSY 681

  Fly   646 TANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSA 710
            |||||||||..|.|:.|:|::||.:|.|:.:|...||||:.||..|:...|||.|..|:...|..
 Worm   682 TANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPV 746

  Fly   711 FTSTNKEGVARVRKEKGGYAFLMETTSLTY-NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNL 774
            |.::..||:.|||..||.||||:|.|:..| |..:.||..::|..:....||:|.|.|||::.::
 Worm   747 FVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHI 811

  Fly   775 SVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD--ELSIIELGGVFLVLAGGVLIGVILGI 837
            :::||.|.|||||:|::||||.:.. .||:...|||.  .|::.::.|:|.:|.||::|.::..:
 Worm   812 NLAILALQERGELKKLENKWWYDRG-QCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAAL 875

  Fly   838 FEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRIS----------SSSDKSSSRRSSG 892
            .|||:..:   :|.|.:...:..|.....||..:..: :|:|          |.|..:..|:...
 Worm   876 GEFLYRSR---IEARKSNSNSMVANFAKNLKSALSSQ-LRLSVEGGAVAQPGSQSHNAIRRQQVA 936

  Fly   893 SRRSSKEKSRSKTV 906
            :...:.||.....|
 Worm   937 AFLPANEKEAFNNV 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	75/393 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	146/385 (38%)
		Lig_chan	555..828	CDD:459656	110/279 (39%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	32..442	CDD:380603	75/397 (19%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:473866	145/386 (38%)