DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and glr-1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_498887.2	Gene:	glr-1 / 176204	WormBaseID:	WBGene00001612	Length:	962	Species:	Caenorhabditis elegans

Alignment Length:	924	Identity:	252/924 - (27%)
Similarity:	425/924 - (45%)	Gaps:	148/924 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYD-LKLEATRQEQLNHQMSIN 141
            |:.:....|:.:..|..|:.........:.:..:::|..:|.:... |..:..:|:|..:...::
Worm    80 SWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVS 144

  Fly   142 VAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDL-MNIQALNSDYVKL---------R 196
            |.|.:|.| .|.|.:.|.   |....::.:.......|..| .:::...:..||.         :
Worm   145 VRPPISEL-LADFIVHKG---WGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEK 205

  Fly   197 NLADYADDYRILWKETDETFHEQRIILDC-EPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSG 260
            ....|...:.::  ..:||   .||::|| .||.||:|| ::|        |:......:.|..
Worm   206 QFEAYLMQFNMM--RNNET---NRILIDCASPKRLKKLL-INI--------RSAQFNQANYHYV- 255

  Fly   261 LRDIYNEDF-----------KANITSVRLKVVDANPFERKKTRL-----------TKVDQILGNQ 303
               :.|.||           ..||:...:...|...:...|..|           ..|:..:|:.
Worm   256 ---LANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHD 317

  Fly   304 TMLPILIYDAVVLFASSARNVIAAMQPFHPPNRH------------CGSSS-------PW----- 344
            .||        |.:...|:.:.|....||...||            |...|       |:
Worm   318 AML--------VTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPFSSFEH 374

  Fly   345 --MLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIY------KPTVN-EPMMVWTP 400
              .:|....| ||...::..    .|.|::.|.:|.|.:|::.|.      |.|.| :.::.|..
Worm   375 GKTIGVAFRN-MKIGHKEGT----LTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQ 434

  Fly   401 DNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKED------HENFRGREKYEGYA 459
            ..|.... ..:...|..:..|..:.:.:  |:|:...|:.|:|.:      ....:|..|:||:.
Worm   435 GVGFFSN-RTVAQHSRKSQNDHKDNQVI--VLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFC 496

  Fly   460 VDLISKLSE-LMEFDYEFMIVNGNGKYNPETKQ----WDGIIRKLIDHHAQIGVCDLTITQMRRS 519
            :||:..|:: :.||:||..:....|     :||    |||:|.:|:...|...|..|||.|.|..
Worm   497 IDLLKLLADKIEEFNYEIKLGTKAG-----SKQADGSWDGMIGELLSGRAHAVVASLTINQERER 556

  Fly   520 VVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWL 584
            ||||:.|||..||||:..|...:..:.|:|::|.:.|:|:|:|||.:.:::....::|.|..||
Worm   557 VVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEW- 620

  Fly   585 PPNPAIQDPDE----LENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTY 645
                .:::...    :.|.::|.|..|..:.:.||||.|||||....||.:..||||.::::|:|
Worm   621 ----RVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSY 681

  Fly   646 TANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSA 710
            |||||||||..|.|:.|:|::||.:|.|:.:|...||||:.||..|:...|||.|..|:...|..
Worm   682 TANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPV 746

  Fly   711 FTSTNKEGVARVRKEKGGYAFLMETTSLTY-NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNL 774
            |.::..||:.|||..||.||||:|.|:..| |..:.||..::|..:....||:|.|.|||::.::
Worm   747 FVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHI 811

  Fly   775 SVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD--ELSIIELGGVFLVLAGGVLIGVILGI 837
            :::||.|.|||||:|::||||.:.. .||:...|||.  .|::.::.|:|.:|.||::|.::..:
Worm   812 NLAILALQERGELKKLENKWWYDRG-QCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAAL 875

  Fly   838 FEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRIS----------SSSDKSSSRRSSG 892
            .|||:..:   :|.|.:...:..|.....||..:..: :|:|          |.|..:..|:...
Worm   876 GEFLYRSR---IEARKSNSNSMVANFAKNLKSALSSQ-LRLSVEGGAVAQPGSQSHNAIRRQQVA 936

  Fly   893 SRRSSKEKSRSKTV 906
            :...:.||.....|
Worm   937 AFLPANEKEAFNNV 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	74/392 (19%)
		ANF_receptor	46..386	CDD:279440	69/367 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	146/385 (38%)
		Lig_chan	556..828	CDD:278489	110/278 (40%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	10..439	CDD:107375	75/393 (19%)
		ANF_receptor	44..417	CDD:279440	70/371 (19%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:304360	145/386 (38%)
		Lig_chan	593..867	CDD:278489	111/279 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810