DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and glr-2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001021114.1	Gene:	glr-2 / 175999	WormBaseID:	WBGene00001613	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	1012	Identity:	268/1012 - (26%)
Similarity:	444/1012 - (43%)	Gaps:	186/1012 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DRNEITVGAIFY----ENEKEIELSFDQAFREVNN--------------MKFSELRFVTIKRYMP 74
            ::|.:..|.:.:    |..|:..|....|..:::|              |.|:.|..|.....:.
Worm     2 NKNLLVFGFLIFVKIGETSKKFPLRAFVASTDIDNDTAHAIIEMLRLAEMTFNALSDVDFDVLLG 66

  Fly    75 TND---------SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATR 130
            |.|         .:.|.:|.|:.:..|...:...::.....|...|||...:|.|::    |.::
Worm    67 TRDLPPMEMATMMWNLNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDW----EPSK 127

  Fly   131 QEQL-----NHQMSINVAPSLSVLSRAYFEIIKSNYE-WRTFTLIYETPEGLARLQDLMNIQALN 189
            .|.:     |:.|..:||||...|...|.:     |: ||....|::.......|:.:.:.....
Worm   128 SENIGKTTENNPMIFSVAPSAEQLLIDYIQ-----YKGWRDVVYIHDGKNADRTLRTMFSYLHEK 187

  Fly   190 SDYVKLRNLADYADDY-----RILWKETDETFHEQRIILDCEPKTLK---------ELLKVSIDF 240
            |...:|     :.|:|     ..::||....|| :||   ....|||         |.:.|::..
Worm   188 SPKYQL-----FVDNYVAPSDEEMFKEFLNEFH-RRI---STQHTLKSNDSSEEIDEPIPVNVIV 243

  Fly   241 KLQGPFR------------------NWFLTHLDTHNSGLRDIYNEDFK-ANITSVRLKVVDANPF 286
            .|:|.:|                  ::..::.|...:.|...:   |. .|||..|  :.|.|..
Worm   244 DLEGSYRTRAFLRALEESVLVKKEYHYVFSNFDVDETDLSGFH---FSLINITIFR--IFDKNNK 303

  Fly   287 ERKKTRLTKVDQILG---NQTMLP---ILIYDAVVLFASSARNVIAAM---------------QP 330
            :..|||....|...|   |...:|   ...:|| :|.|..|..:  ||               |.
Worm   304 KFLKTRAEFHDVYRGGFSNTDSIPTAAAFAHDA-ILVAGKALQI--AMNEHGKGIFDKSFVRHQL 365

  Fly   331 F-----------HPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEY-GQRIHFN 383
            |           |...........:..|..|...:|.:...|.:... |..::.|:. |:|.:|:
Worm   366 FNRGRKGLYCRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTL-TGRIQFDKVTGKRTNFS 429

  Fly   384 LEI--YKPTVNEPMMV-----WTPDNGIKKRLLNLELESAGTTQDFSEQRK----------VYTV 431
            .||  .||.||....:     |....|.   ||..|.......:|.|:.||          .:.|
Worm   430 AEIVEIKPGVNSLNSIWERFQWAEGEGF---LLGGERYVQEKKKDSSQTRKGILPSKPWQLRFNV 491

  Fly   432 VTHYEEPYFMMKE---DHENFRGREKYEGYAVDLISKLSE-LMEFDYEFMIVNGNGKYNPETK-- 490
            ||...:|:.|:|.   .....:|.:::|||.:||::.|:: :..|:|:..|.:|| ||.....
Worm   492 VTVLVKPFVMLKRRNPGEPELKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGN-KYGSRQADG 555

  Fly   491 QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAV 555
            .|||:|..|::..|.:.|..|||||.|...|||:.|||..||||:..|...:..|.|:|:||..:
Worm   556 SWDGMIGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGM 620

  Fly   556 EVWIYMIFAQLIMTLAFVFIARLSYREWLPP-NPAIQ---DPDELENIWNVNNSTWLMVGSIMQQ 616
            .:||:.:.:...::|....::      |..| ...|:   ....:.|.:.:.||.|..:.:.|||
Worm   621 TIWIFTLSSYFGVSLTIFLVS------WFSPYEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQ 679

  Fly   617 GCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRG 681
            |.|||||....||.:..||||.|:::|:||||||||||..:....|:|::||..|:|:.:|...|
Worm   680 GTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLANQNKILYGVNEG 744

  Fly   682 GSTSLFFSESNDTDYQRAWNQM----------------KDFNPSAFTSTNKEGVARVRKEKGGYA 730
            |||:.||.:|....|::.||.|                ...:...|.|:..:|:.:||..||.||
Worm   745 GSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYA 809

  Fly   731 FLMETTSLTYNI-ERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKW 794
            ||:|.|:..|.. .|.||..::|:.:....||:|..:|:..|.:|:::||.|||:|||:|::|||
Worm   810 FLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKW 874

  Fly   795 WKNHNVTCDSYHEVDG--DELSIIELGGVFLVLAGGVLIGVILGIFEFLW--NVQNVAVE-ERVT 854
            |.:.. .||:.....|  ..|::.::.|:|.:|..|:::.:...:.|||:  |.:|...| .|:.
Worm   875 WYDRG-QCDTGTSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENREKERNRMR 938

  Fly   855 PWQAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSS 891
            ..:..|..::.:.:...:|:.....:.|::.|:.||:
Worm   939 SSRPLKPGILASCERAKQKQLQNRRTKSEEVSTPRST 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	97/476 (20%)
		ANF_receptor	46..386	CDD:279440	87/434 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	142/406 (35%)
		Lig_chan	556..828	CDD:278489	99/294 (34%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	97/472 (21%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	139/390 (36%)
		Lig_chan	621..910	CDD:278489	99/295 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910