DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and glr-4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	966	Identity:	271/966 - (28%)
Similarity:	445/966 - (46%)	Gaps:	184/966 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YAFIIIIGFLEGIIALGGDDRNEI-TV---GAIFYENEKEIELSFDQAFRE---VNNMKFSELRF 66
            ::.:::|.::....|   |||..| |:   |:..||:   :..:.|:...|   ...:|||   .
Worm    11 FSILLVIFYIANSAA---DDRFHIGTIANRGSFAYEH---LRYAIDRWNTEHGAHTQIKFS---I 66

  Fly    67 VTIKRYMPTNDSFLLQQITCELISNGVAAIF--GPSSKAASDIVAQIANATGIPHIEYDLKLEAT 129
            |:..||   ::::  ::..||::..|:.|:.  ...|:..|.::..:.:...||    .|.|::|
Worm    67 VSPIRY---DNNY--EERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIP----CLSLQST 122

  Fly   130 RQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQAL-----N 189
            ............:.||....:||..|.:.| ..|..|.|.|:....|..|..||..:.:     .
Worm   123 SLRDSVSDFVTLLGPSRGAGARATSEFLDS-MRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTGGR 186

  Fly   190 SDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKT-LKELLKVSIDFKLQGPFRNWFLTH 253
            ..::|:|.|.:..|||....|.......:..||:.....| |..||:.:....:..|..::..|:
Worm   187 RIHIKIRRLPNNTDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFSYVFTN 251

  Fly   254 LDTH--NSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVL 316
            .|..  ...|.::|...|..|||.  |::|..:|..:.:..||.                :||.:
Worm   252 TDLSLLEDFLNNMYGASFHCNITG--LQLVKNDPMMKTQLALTS----------------EAVYV 298

  Fly   317 FASSARNVIAAMQPF-HPPNRH---CGSSSPWMLGAFIVNE----------------MKTISE-D 360
            ...|    |..|:.. |.|.:.   |.|...|..|. |:||                .|:..| |
Worm   299 VGMS----IYRMRELGHAPRQSSIMCDSHDIWSDGR-IMNEGIRKLKLRNQLTGDVQFKSNGERD 358

  Fly   361 DVEPH----FKTENMKL------------DEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLL 409
            |:..|    ..::.:||            ..|..|..|:::              ||:   :.|.
Worm   359 DIMYHGVGRINSQFVKLGNWSEKRGWNFDSRYANRWEFDID--------------PDS---EDLE 406

  Fly   410 NLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDY 474
            .|.|.                ||.:.||| |::|      .|..:|||:.:||:::::::::|:|
Worm   407 GLHLR----------------VVVYLEEP-FVIK------TGENQYEGFCIDLLNEMTQVLKFNY 448

  Fly   475 EFMIVNGNGKY--NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHY 537
            ..:.|. :|.|  ..|:.:|:|||..|..|.|.:.:..:|||..|..|||||:|||.||||||..
Worm   449 TIIEVQ-DGTYGIEDESGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLA 512

  Fly   538 KSPPEPK--NQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIW 600
            ::..|..  :.:.||||.::.|||.::.:..|::.:...:|:.|..||.  |....|..:.|||.
Worm   513 RTSEETDKGSLWTFLEPLSLTVWISLLISYCIVSYSMHILAKFSPYEWY--NLERIDERDFENIK 575

  Fly   601 N------VNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQ 659
            |      |.||.|..:||:||||.|::||....|::..:||.|..:::|:|||.||||||..:..
Worm   576 NQKNQFTVLNSFWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMS 640

  Fly   660 SSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRK 724
            :.|:|.|||..|.|:.:|.::.|||..||.||....|:|.|:.|:..:|..|.::::||:|||:
Worm   641 TPIESTQDLANQQKIRYGVLKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVK- 704

  Fly   725 EKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQK 789
             .||||::||::.|.|.:||:|:|..||..:..|.||:|:|.||..|..||.::|||.||..|:.
Worm   705 -SGGYAYMMESSMLEYYLERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEA 768

  Fly   790 MKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEER 852
            :|||||::  ...:|...............:.|:|.||..|:::..:|...|:       .:|.|
Worm   769 LKNKWWRDRREGPSCGPPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGEY-------CIESR 826

  Fly   853 VTPWQAFKAELIFALKF--WVRKKPMRISSSSDKSSSRRSSGSRRSSKEKSRSKTV 906
               .:||:.:|....||  |.|                   |:...||::|:.:.:
Worm   827 ---HEAFRLKLTIVGKFMDWYR-------------------GNSNDSKQRSKLRNM 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	90/423 (21%)
		ANF_receptor	46..386	CDD:279440	84/389 (22%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	150/379 (40%)
		Lig_chan	556..828	CDD:278489	107/279 (38%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	86/393 (22%)
		ANF_receptor	45..365	CDD:279440	79/355 (22%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	151/392 (39%)
		Lig_chan	533..810	CDD:278489	107/280 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920