Protein Alignment GluRIIA and nmr-1

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_495033.2
• Gene: nmr-1 / 173929
• WormBaseID: WBGene00003774
• Length: 1025
• Species: Caenorhabditis elegans
• Alignment Length: 997
• Identity: 214/997 - (21%)
• Similarity: 376/997 - (37%)
• Gaps: 270/997 - (27%)

  Fly    74 PTNDSF--LLQQITCELISNGVAAIFGPSS-KAASDIVAQIANATGIPHIEYDLKLEATR----Q 131
            |..::|  |...:|...:.     :||.:| ...:|.:    :|..:.....|.:||.|:    .
 Worm    31 PNQETFKELKVSVTAAFVE-----VFGSTSYHLGNDTI----SAAFVDAKSGDNRLELTQDIVCS 86

  Fly   132 EQLNHQM-SINVAPSLSVLSRAYFEIIKSNYEWRTFTL-IYETPEGLARLQDLMNIQALNSDYVK 194
            :.|||.: |:..:|.|:..|| :.:::.|:    .:|| .|:.|        ::.:...::::.|
 Worm    87 QMLNHSLASVIFSPLLTSSSR-FIDLVTSS----AYTLSFYKLP--------VVGVMVRDAEFSK 138

  Fly   195 LRNLADYADDYRILWKETDETF----------HEQRIILDCE-----PKTLKELLKVSIDFKLQG 244
             :|:  |....|.....:||.|          :.|.::|..:     .:.::|..|..::||:
 Worm   139 -KNI--YPTFVRPTAPLSDEAFVFLHMLLSLKYRQVVVLSVKRDINADQFVEEFEKRRVEFKI-- 198

  Fly   245 PFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPIL 309
            ..:.:....|   |..|.|...|.|                           :::..|..:|...
 Worm   199 IVQRYIEVEL---NENLNDTLAESF---------------------------EEVTSNIIVLFAK 233

  Fly   310 IYDAVVLFASS------------------ARNVIAAMQPFHPPNRHCGSSSPWMLG--AFIV--- 351
            ..|||.:||::                  |.||         ||...|.    .||  ||.|
 Worm   234 KDDAVRIFANAGDLTGKGKVWIVSESAGEAHNV---------PNGSLGC----RLGQTAFSVLRD 285

  Fly   352 ------NEMKTI---SEDDVEPHFKTENMKLD-EYG----------------QRIHFN------- 383
                  :.|:||   |:.|:.|..:.:...:| |:.                .|:|||
 Worm   286 SFSILKSAMETIFRESKIDIFPPVECDRDSVDAEWNSLQAPALLNEICGTSTSRVHFNDKCERIG 350

  Fly   384 --------------------------------------LEIYKP------TVNEPMMVWTPDNGI 404
                                                  |||..|      ||.:|..|:|...|.
 Worm   351 VEYDIINFHMERKQVGNMVGDILRLDEDSIEWAGGTKPLEISLPKHLRVVTVADPPFVYTTPIGS 415

  Fly   405 KKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLS-- 467
            ..:...|    ..|..::|...|:......|..|..:     ||........|.|:||:|.||
 Worm   416 PSQCAEL----GNTVVEWSIFDKIVVSGPWYSCPLTL-----ENSTEYFCCAGLAIDLLSNLSLP 471

  Fly   468 ---ELMEFDYEFMIVNGNGKYN----PETK--QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDF 523
               ..::..:.|.: :.|..|.    .||.  ...|:|.:|....|.:.:..:||...|..:|||
 Worm   472 EANNSIDTSFTFSL-HLNESYGVVQASETTGITISGVIGELDGDTADMAIGGITINPERERIVDF 535

  Fly   524 TVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNP 588
            |.|::..||.||. |:.|......:||:|....:|..:..:.:::.||   |..|.::.  |...
 Worm   536 TEPWLYHGIRILE-KNIPRDSPMQSFLQPLQSSLWTALFISVILVGLA---IYCLDFKS--PFER 594

  Fly   589 AIQDPDELE-------NIW-------NVN--NSTWLMVGSIMQQG-CDILPRGPHMRILTGMWWF 636
            ..|...|:|       .:|       |||  .:.|.:.|.::..| .:..||....|:|..:|..
 Worm   595 FYQADKEMEQDLKKEFELWIGKDADENVNFGEAMWFVWGVLLNSGVSEKTPRSCSARVLGIVWCG 659

  Fly   637 FALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFS---ESNDTDYQR 698
            |.::|:::|||||||||..::.:..:..:.|         ..:|..|.:..|.   .||...|.:
 Worm   660 FCMIMVASYTANLAAFLVLDQPEKGLTGVTD---------PRLRNPSANFSFGTVLNSNVYQYFK 715

  Fly   699 AWNQMKDFNPSAFTSTNKEGVARVRKE-----KGGY-AFLMETTSLTYNIERNCDLTQIGEQIGE 757
            ...::.    |.|.......|.|..:.     .|.. ||:.::|.|.:...|:|:|...|...|.
 Worm   716 RHVELS----SMFRKMEPHNVRRASEAVHSLLNGSLDAFIWDSTRLEFEAARHCELRTRGSLFGR 776

  Fly   758 KHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVF 822
            ..||:.:...|.:..:::.:||::||.|.::|:..||.......|..........|.::.:..:|
 Worm   777 SAYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQKWIDRGGPNCVVEAHKSPARLGLVNMKDIF 841

  Fly   823 LVLAGGVLIGVILGIFEFLWNVQNVAVEER----VTPWQAFKAELIFALKFWVRKKPMRISSSSD 883
            ::::.||.:|:.|...|..:. :.:|.:.|    ||.:.....:|....|    ::|.|:..:.|
 Worm   842 ILVSSGVALGIFLSFVEVSYG-RRLADKGRRRRIVTRYFQKWHDLTLGKK----RRPYRLKYNLD 901

  Fly   884 KSSSRRS-SGSRRSSKEKSRSK 904
            :...||. ||..|.|.::.|.:
 Worm   902 RMIVRRGFSGLERCSFQELRER 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	85/454 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	102/406 (25%)
		Lig_chan	555..828	CDD:459656	67/298 (22%)
nmr-1	NP_495033.2	Periplasmic_Binding_Protein_type1	19..384	CDD:471960	75/422 (18%)
		PBP2_iGluR_NMDA_Nr1	394..822	CDD:270437	112/456 (25%)
		Lig_chan	566..844	CDD:459656	67/295 (23%)
		LITAF	949..1017	CDD:197841